EA032271B9 - Вещества, фармацевтическая композиция и методы применения при лечении воспалительных заболеваний - Google Patents

Вещества, фармацевтическая композиция и методы применения при лечении воспалительных заболеваний

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Publication number
EA032271B9
EA032271B9 EA201690783A EA201690783A EA032271B9 EA 032271 B9 EA032271 B9 EA 032271B9 EA 201690783 A EA201690783 A EA 201690783A EA 201690783 A EA201690783 A EA 201690783A EA 032271 B9 EA032271 B9 EA 032271B9
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EA
Eurasian Patent Office
Prior art keywords
compounds
inflammatory diseases
methods
pharmaceutical composition
treating inflammatory
Prior art date
Application number
EA201690783A
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English (en)
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EA201690783A1 (ru
EA032271B1 (ru
Inventor
Хамид Ховейда
Дидье Шилс
Людивин Зут
Жюльен Парк
Жером Бернар
Грэм Фрейзер
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Огеда Са
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Application filed by Огеда Са filed Critical Огеда Са
Publication of EA201690783A1 publication Critical patent/EA201690783A1/ru
Publication of EA032271B1 publication Critical patent/EA032271B1/ru
Publication of EA032271B9 publication Critical patent/EA032271B9/ru

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Изобретение относится к применению соединений формулыгде R, R, R, R, R, R, D, L, Ar, Arимеют такие значения, как приведено в описании, или их фармацевтически приемлемых солей для лечения и/или предотвращения воспалительных заболеваний.
EA201690783A 2013-11-27 2014-11-27 Вещества, фармацевтическая композиция и методы применения при лечении воспалительных заболеваний EA032271B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13194730 2013-11-27
PCT/EP2014/075768 WO2015078949A1 (en) 2013-11-27 2014-11-27 Compounds, pharmaceutical composition and methods for use in treating inflammatory diseases

Publications (3)

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EA201690783A1 EA201690783A1 (ru) 2016-08-31
EA032271B1 EA032271B1 (ru) 2019-05-31
EA032271B9 true EA032271B9 (ru) 2019-08-30

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US (1) US9770435B2 (ru)
EP (2) EP3610872A1 (ru)
JP (2) JP6854126B2 (ru)
KR (1) KR102259934B1 (ru)
CN (2) CN105916500A (ru)
AU (1) AU2014356460B2 (ru)
BR (1) BR112016011917B1 (ru)
CA (1) CA2929436C (ru)
DK (1) DK3074008T3 (ru)
EA (1) EA032271B9 (ru)
ES (1) ES2755332T3 (ru)
HK (1) HK1224184A1 (ru)
MX (1) MX2016006975A (ru)
WO (1) WO2015078949A1 (ru)

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WO2017165139A1 (en) 2016-03-25 2017-09-28 St. Jude Children's Research Hospital 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane x receptor
IL300572A (en) 2018-02-13 2023-04-01 Gilead Sciences Inc PD–1/PD–L1 inhibitors
JP7242702B2 (ja) 2018-04-19 2023-03-20 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
PT3820572T (pt) 2018-07-13 2023-11-10 Gilead Sciences Inc Inibidores pd-1/pd-l1
AU2019366355B2 (en) 2018-10-24 2022-10-13 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
MX2022015718A (es) 2020-06-10 2023-01-24 Epics Therapeutics Sintesis del acido (2s,5r)-5-(2-clorofenilo)-1-(2'-metoxi-[1,1'-bi fenilo]-4-carbonilo)pirrolidina-2-carboxilico.
KR102394875B1 (ko) * 2021-05-11 2022-05-06 주식회사 비드테크 피롤리딘을 링커로 포함하는 화합물 및 이를 포함하는 약학 조성물
CN113816818B (zh) * 2021-09-17 2023-07-25 哈尔滨工业大学（深圳） 一种铜催化不对称烯丙基烷基化反应方法及手性化合物

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CA2929436A1 (en) 2015-06-04
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