HK1224184A1 - 用於治療炎性疾病的化合物、藥物組合物和方法 - Google Patents

用於治療炎性疾病的化合物、藥物組合物和方法

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Publication number
HK1224184A1
HK1224184A1 HK16112446.7A HK16112446A HK1224184A1 HK 1224184 A1 HK1224184 A1 HK 1224184A1 HK 16112446 A HK16112446 A HK 16112446A HK 1224184 A1 HK1224184 A1 HK 1224184A1
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HK
Hong Kong
Prior art keywords
compounds
methods
pharmaceutical composition
inflammatory diseases
treating inflammatory
Prior art date
Application number
HK16112446.7A
Other languages
English (en)
Inventor
Hamid Hoveyda
Didier Schils
Ludivine Zoute
Julien Parcq
Jrme Beernard
Graeme Fraser
Original Assignee
Ogeda Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ogeda Sa filed Critical Ogeda Sa
Publication of HK1224184A1 publication Critical patent/HK1224184A1/zh

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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HK16112446.7A 2013-11-27 2016-10-28 用於治療炎性疾病的化合物、藥物組合物和方法 HK1224184A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13194730 2013-11-27
PCT/EP2014/075768 WO2015078949A1 (en) 2013-11-27 2014-11-27 Compounds, pharmaceutical composition and methods for use in treating inflammatory diseases

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US (1) US9770435B2 (zh)
EP (2) EP3610872A1 (zh)
JP (2) JP6854126B2 (zh)
KR (1) KR102259934B1 (zh)
CN (2) CN105916500A (zh)
AU (1) AU2014356460B2 (zh)
BR (1) BR112016011917B1 (zh)
CA (1) CA2929436C (zh)
DK (1) DK3074008T3 (zh)
EA (1) EA032271B9 (zh)
ES (1) ES2755332T3 (zh)
HK (1) HK1224184A1 (zh)
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WO (1) WO2015078949A1 (zh)

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US10550091B2 (en) 2016-03-25 2020-02-04 St. Jude Children's Research Hospital 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
AU2019222644B2 (en) 2018-02-13 2021-04-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
CN112041311B (zh) 2018-04-19 2023-10-03 吉利德科学公司 Pd-1/pd-l1抑制剂
EP4234030A3 (en) 2018-07-13 2023-10-18 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
WO2020086556A1 (en) 2018-10-24 2020-04-30 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
US20230271921A1 (en) 2020-06-10 2023-08-31 Epics Therapeutics Synthesis of (2s,5r)-5-(2-chlorophenyl)-1-(2'-methoxy-[1,1'-biphenyl]-4- carbonyl)pyrrolidine-2-carboxylic acid
KR102394875B1 (ko) * 2021-05-11 2022-05-06 주식회사 비드테크 피롤리딘을 링커로 포함하는 화합물 및 이를 포함하는 약학 조성물
CN113816818B (zh) * 2021-09-17 2023-07-25 哈尔滨工业大学（深圳） 一种铜催化不对称烯丙基烷基化反应方法及手性化合物
US12054457B2 (en) 2022-10-11 2024-08-06 Epics Therapeutics Polymorphs of (2S,5R)-5-(2-chlorophenyl)-1-(2′-methoxy-[1,1′-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid and preparation processes thereof

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