MX362919B - Moduladores del receptor acoplado a proteína-g 120 (gpr120) de ácido biciclo-[2.2.1]. - Google Patents

Moduladores del receptor acoplado a proteína-g 120 (gpr120) de ácido biciclo-[2.2.1].

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Publication number
MX362919B
MX362919B MX2015011375A MX2015011375A MX362919B MX 362919 B MX362919 B MX 362919B MX 2015011375 A MX2015011375 A MX 2015011375A MX 2015011375 A MX2015011375 A MX 2015011375A MX 362919 B MX362919 B MX 362919B
Authority
MX
Mexico
Prior art keywords
bicyclo
gpr120 modulators
acid
acid gpr120
modulators
Prior art date
Application number
MX2015011375A
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English (en)
Other versions
MX2015011375A (es
Inventor
Wang Ying
Shi Yan
T W Cheng Peter
C Wu Shung
Hao Zhang
Original Assignee
Bristol Myers Squibb Co
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Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2015011375A publication Critical patent/MX2015011375A/es
Publication of MX362919B publication Critical patent/MX362919B/es

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Abstract

La invención proporciona compuestos de la fórmula (I): (I) o un estereoisómero, o una sal farmacéuticamente aceptable del mismo, en donde todas de las variables son como se definen en la presente. Estos compuestos son moduladores del receptor acoplado a proteína G de GPR120 que se pueden usar como medicamentos.
MX2015011375A 2013-03-14 2014-03-13 Moduladores del receptor acoplado a proteína-g 120 (gpr120) de ácido biciclo-[2.2.1]. MX362919B (es)

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PCT/US2014/025153 WO2014159794A2 (en) 2013-03-14 2014-03-13 Bicyclo [2.2.1] acid gpr120 modulators

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US9580420B2 (en) * 2014-08-06 2017-02-28 Bristol-Meyers Squibb Company Process for the preparation of 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates therefor
US20170327457A1 (en) 2014-09-09 2017-11-16 Bristol-Myers Squibb Company Phenyl-(aza)cycloalkyl carboxylic acid gpr120 modulators
US10023519B2 (en) 2014-09-09 2018-07-17 Bristol-Myers Squibb Company Cyclobutane containing carboxylic acid GPR120 modulators
US9938222B2 (en) 2014-09-09 2018-04-10 Bristol-Myers Squibb Company Cyclopropanecarboxylic acid GPR120 modulators
KR101829290B1 (ko) * 2014-12-24 2018-02-19 주식회사 엘지화학 Gpr120 효능제로서의 바이아릴 유도체
EP3509587B1 (en) 2016-09-12 2023-12-06 Valo Health, Inc. Monocyclic compounds useful as gpr120 modulators
US11597702B2 (en) 2018-03-15 2023-03-07 Golgi Neurosciences S.R.L. Substituted pyrazoles FFA4/GPR120 receptor agonists

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US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
FR2746101B1 (fr) * 1996-03-14 1998-04-30 Composes bicycliques-aromatiques
US6008234A (en) * 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
BR0010138B1 (pt) * 1999-04-30 2012-12-11 moduladores de receptores de glicocorticóides.
FR2849599B1 (fr) * 2003-01-07 2006-12-29 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete
KR20100090249A (ko) * 2007-10-10 2010-08-13 암젠 인크 치환된 비페닐 ｇｒｐ４０ 조절제
US9035059B2 (en) 2011-03-14 2015-05-19 Taisho Pharmaceutical Co., Ltd. Nitrogen-containing condensed heterocyclic compound
US8962660B2 (en) 2013-03-14 2015-02-24 Bristol-Myers Squibb Company Oxabicyclo [2.2.2] acid GPR120 modulators

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BR112015021990A2 (pt) 2017-07-18
US20160016880A1 (en) 2016-01-21
EP2970092B1 (en) 2016-12-14
IL241245A0 (en) 2015-11-30
SG11201506796XA (en) 2015-09-29
EA201591795A1 (ru) 2015-12-30
AU2014244474A1 (en) 2015-11-05
JP2016520517A (ja) 2016-07-14
EP2970092A2 (en) 2016-01-20
CN105189439B (zh) 2017-12-29
IL241245A (en) 2017-12-31
WO2014159794A3 (en) 2014-12-11
CN105189439A (zh) 2015-12-23
KR20150127208A (ko) 2015-11-16
MX2015011375A (es) 2016-01-15
CA2905428A1 (en) 2014-10-02
AU2014244474B2 (en) 2018-04-26
US9518000B2 (en) 2016-12-13

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