FR2849599B1 - Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete - Google Patents
Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabeteInfo
- Publication number
- FR2849599B1 FR2849599B1 FR0300107A FR0300107A FR2849599B1 FR 2849599 B1 FR2849599 B1 FR 2849599B1 FR 0300107 A FR0300107 A FR 0300107A FR 0300107 A FR0300107 A FR 0300107A FR 2849599 B1 FR2849599 B1 FR 2849599B1
- Authority
- FR
- France
- Prior art keywords
- kynurenine
- diabetes
- treatment
- hydroxylase inhibitors
- hydroxylase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/06—Phenols the aromatic ring being substituted by nitro groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (35)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0300107A FR2849599B1 (fr) | 2003-01-07 | 2003-01-07 | Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete |
FR0314263A FR2849598B1 (fr) | 2003-01-07 | 2003-12-04 | Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans |
AU2003293937A AU2003293937B2 (en) | 2003-01-07 | 2003-12-18 | Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes |
EP03814462A EP1581216A1 (fr) | 2003-01-07 | 2003-12-18 | Inhibiteurs de kynurenine 3-hydroxylase pour le traitement de diabetes par l augmentation du nombre des ilots de cellules de langerhans |
CNA2003801084540A CN1735411A (zh) | 2003-01-07 | 2003-12-18 | 用于治疗糖尿病的犬尿氨酸3-羟基化酶抑制剂 |
CNA2003801084521A CN1735410A (zh) | 2003-01-07 | 2003-12-18 | 用于通过增加胰岛细胞的数量来治疗糖尿病的犬尿氨酸3-羟基化酶抑制剂 |
MXPA05007293A MXPA05007293A (es) | 2003-01-07 | 2003-12-18 | Uso de inhibidores de quinurenina 3-hidroxilasa para el tratamiento de la diabetes por incremento de la cantidad de celulas de los islotes de langerhans. |
RU2005125086/04A RU2005125086A (ru) | 2003-01-07 | 2003-12-18 | Ингибиторы кинуренин 3-гидроксилазы для лечения диабета путем повышения количества островков клеток лангерганса |
PCT/EP2003/014539 WO2004060369A1 (fr) | 2003-01-07 | 2003-12-18 | Inhibiteurs de la kynurenine 3-hydroxylase pour le traitement du diabete |
PL03376017A PL376017A1 (en) | 2003-01-07 | 2003-12-18 | Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes by increasing the number of islets of langerhans cells |
KR1020057012707A KR20050090447A (ko) | 2003-01-07 | 2003-12-18 | 당뇨병 치료용 키뉴레닌 3-하이드록실라제 저해제 |
BR0317950-8A BR0317950A (pt) | 2003-01-07 | 2003-12-18 | Inibidores de quinurrenina 3-hidroxilase para o tratamento de diabetes por aumento do número de ilhotas de células de langerhans |
KR1020057012652A KR20050090443A (ko) | 2003-01-07 | 2003-12-18 | 랑게르한스섬 세포 수를 증가시킴으로써 당뇨병을 치료하는키뉴레닌-3-하이드록실라제 저해제 |
DE60331359T DE60331359D1 (de) | 2003-01-07 | 2003-12-18 | Kynurenine 3-hydroxylase inhibitoren zur behandlung von diabetes |
EP03789341A EP1581215B1 (fr) | 2003-01-07 | 2003-12-18 | Inhibiteurs de la kynurenine 3-hydroxylase pour le traitement du diabete |
JP2004564203A JP2006515594A (ja) | 2003-01-07 | 2003-12-18 | ランゲルハンス島細胞数を増加させることによって糖尿病を治療するためのキヌレニン3−ヒドロキシラーゼ阻害剤 |
AU2003296679A AU2003296679A1 (en) | 2003-01-07 | 2003-12-18 | Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes by increasing the number of islets of langerhans cells |
RU2005125085/15A RU2351329C2 (ru) | 2003-01-07 | 2003-12-18 | Ингибиторы кинуренин 3-гидроксилазы для лечения диабета |
JP2004564204A JP4813800B2 (ja) | 2003-01-07 | 2003-12-18 | 糖尿病を治療するためのキヌレニン3−ヒドロキシラーゼ阻害剤 |
CA2512563A CA2512563C (fr) | 2003-01-07 | 2003-12-18 | Inhibiteurs de la kynurenine 3-hydroxylase pour le traitement du diabete |
US10/541,377 US7727977B2 (en) | 2003-01-07 | 2003-12-18 | Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes |
CA002512558A CA2512558A1 (fr) | 2003-01-07 | 2003-12-18 | Inhibiteurs de kynurenine 3-hydroxylase pour le traitement de diabetes par l'augmentation du nombre des ilots de cellules de langerhans |
PL378212A PL378212A1 (pl) | 2003-01-07 | 2003-12-18 | Inhibitory 3-hydroksylazy kynureninowej do leczenia cukrzycy |
PCT/EP2003/014538 WO2004060368A1 (fr) | 2003-01-07 | 2003-12-18 | Inhibiteurs de kynurenine 3-hydroxylase pour le traitement de diabetes par l'augmentation du nombre des ilots de cellules de langerhans |
AT03789341T ATE457725T1 (de) | 2003-01-07 | 2003-12-18 | Kynurenine 3-hydroxylase inhibitoren zur behandlung von diabetes |
MXPA05007292A MXPA05007292A (es) | 2003-01-07 | 2003-12-18 | Uso de inhibidores de quinurenina 3-hidroxilasa para el tratamiento de la diabetes. |
US10/541,493 US20060052456A1 (en) | 2003-01-07 | 2003-12-18 | Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes by increasing the number of islets of langerhans cells |
BR0317947-8A BR0317947A (pt) | 2003-01-07 | 2003-12-18 | Inibidores de quinurenina 3-hidroxilase para o tratamento de diabetes |
ES03789341T ES2339656T3 (es) | 2003-01-07 | 2003-12-18 | Inhibidores de la quinurenina 3-hidroxilasa para el tratamiento de la diabetes. |
TW093100159A TW200503676A (en) | 2003-01-07 | 2004-01-05 | Use of kynurenine 3-hydroxylase inhibitors for the treatment of diabetes |
TW093100157A TW200418820A (en) | 2003-01-07 | 2004-01-05 | Use of kynurenine 3-hydroxylase inhibitors for the treatment of diabetes by increasing the number of islets of Langerhans cells |
ARP040100024A AR043327A1 (es) | 2003-01-07 | 2004-01-07 | Uso de inhibidores de quinurenina 3- hidroxilasa para el tratamiento de la diabetes |
ARP040100025A AR042712A1 (es) | 2003-01-07 | 2004-01-07 | Uso de inhibidores de quinurenina 3- hidroxilasa para el tratamiento de la diabetes por incremento de la cantidad de celulas de los islotes de langerhans |
ZA200506257A ZA200506257B (en) | 2003-01-07 | 2005-08-04 | Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes |
ZA200506252A ZA200506252B (en) | 2003-01-07 | 2005-08-04 | Kynunerine 3-hydroxylase inhibitors for the treatment of diabets by increasing the number of islets of Langerhans cells |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0300107A FR2849599B1 (fr) | 2003-01-07 | 2003-01-07 | Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2849599A1 FR2849599A1 (fr) | 2004-07-09 |
FR2849599B1 true FR2849599B1 (fr) | 2006-12-29 |
Family
ID=32524724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0300107A Expired - Fee Related FR2849599B1 (fr) | 2003-01-07 | 2003-01-07 | Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete |
Country Status (3)
Country | Link |
---|---|
CN (2) | CN1735410A (fr) |
FR (1) | FR2849599B1 (fr) |
ZA (2) | ZA200506252B (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103159618B (zh) * | 2011-12-09 | 2016-05-11 | 天津市国际生物医药联合研究院有限公司 | 4-羰基-2-丁烯酸类化合物及其用途 |
KR20150127208A (ko) * | 2013-03-14 | 2015-11-16 | 브리스톨-마이어스 스큅 컴퍼니 | 비시클로 [2.2.1] 산 gpr120 조절제 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR19990082639A (ko) * | 1996-02-19 | 1999-11-25 | 미즈노 마사루 | 당뇨병 치료제 |
US5877193A (en) * | 1996-07-19 | 1999-03-02 | Hoffmann-La Roche Inc. | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides |
FR2752422B1 (fr) * | 1996-08-16 | 1998-11-06 | Lipha | Composition pharmaceutique contenant des acides 4-oxo-butanoiques |
US6288063B1 (en) * | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
SE0001899D0 (sv) * | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
-
2003
- 2003-01-07 FR FR0300107A patent/FR2849599B1/fr not_active Expired - Fee Related
- 2003-12-18 CN CNA2003801084521A patent/CN1735410A/zh active Pending
- 2003-12-18 CN CNA2003801084540A patent/CN1735411A/zh active Pending
-
2005
- 2005-08-04 ZA ZA200506252A patent/ZA200506252B/en unknown
- 2005-08-04 ZA ZA200506257A patent/ZA200506257B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1735411A (zh) | 2006-02-15 |
FR2849599A1 (fr) | 2004-07-09 |
ZA200506252B (en) | 2006-05-31 |
CN1735410A (zh) | 2006-02-15 |
ZA200506257B (en) | 2006-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |
Effective date: 20081029 |