MX366820B - Moduladores de gpr120 del acido biciclo[2.2.2]. - Google Patents

Moduladores de gpr120 del acido biciclo[2.2.2].

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Publication number
MX366820B
MX366820B MX2015011932A MX2015011932A MX366820B MX 366820 B MX366820 B MX 366820B MX 2015011932 A MX2015011932 A MX 2015011932A MX 2015011932 A MX2015011932 A MX 2015011932A MX 366820 B MX366820 B MX 366820B
Authority
MX
Mexico
Prior art keywords
bicyclo
gpr120 modulators
modulators
acid
acid gpr120
Prior art date
Application number
MX2015011932A
Other languages
English (en)
Other versions
MX2015011932A (es
Inventor
Shi Yan
Zhang Hao
T W Cheng Peter
Tao Shiwei
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2015011932A publication Critical patent/MX2015011932A/es
Publication of MX366820B publication Critical patent/MX366820B/es

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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de Fórmula (I) o un estereoisómero, o una sal del mismo farmacéuticamente aceptable, en donde todas las variables son como se definen en la presente. Estos compuestos son moduladores del receptor acoplado a la proteína G GPR120, los cuales pueden ser usados como medicamentos.
MX2015011932A 2013-03-14 2014-03-13 Moduladores de gpr120 del acido biciclo[2.2.2]. MX366820B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361782396P 2013-03-14 2013-03-14
PCT/US2014/025187 WO2014159802A1 (en) 2013-03-14 2014-03-13 Bicyclo [2.2.2] acid gpr120 modulators

Publications (2)

Publication Number Publication Date
MX2015011932A MX2015011932A (es) 2015-12-01
MX366820B true MX366820B (es) 2019-07-25

Family

ID=50639933

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015011932A MX366820B (es) 2013-03-14 2014-03-13 Moduladores de gpr120 del acido biciclo[2.2.2].

Country Status (14)

Country Link
US (1) US9598390B2 (es)
EP (1) EP2970172B1 (es)
JP (1) JP2016516708A (es)
KR (1) KR20150130398A (es)
CN (1) CN105209447B (es)
AU (1) AU2014244482B2 (es)
BR (1) BR112015021386A2 (es)
CA (1) CA2905431A1 (es)
EA (1) EA201591815A1 (es)
ES (1) ES2765973T3 (es)
IL (1) IL241318B (es)
MX (1) MX366820B (es)
SG (1) SG11201506800YA (es)
WO (1) WO2014159802A1 (es)

Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
US10023519B2 (en) 2014-09-09 2018-07-17 Bristol-Myers Squibb Company Cyclobutane containing carboxylic acid GPR120 modulators
US20170327457A1 (en) 2014-09-09 2017-11-16 Bristol-Myers Squibb Company Phenyl-(aza)cycloalkyl carboxylic acid gpr120 modulators
EP3191454B1 (en) 2014-09-09 2018-10-24 Bristol-Myers Squibb Company Cyclopropanecarboxylic acid gpr120 modulators
CN115215886B (zh) 2016-09-09 2024-10-11 诺华股份有限公司 作为内体Toll样受体抑制剂的化合物及组合物
EP3529230B1 (en) 2016-10-19 2020-09-30 Eastman Chemical Company Synthesis of bicyclo(2.2.2)octanes
AU2018255269B2 (en) 2017-04-17 2023-03-09 The University Of Chicago Polymer materials for delivery of short-chain fatty acids to the intestine for applications in human health and treatment of disease
WO2019075004A1 (en) 2017-10-11 2019-04-18 Eastman Chemical Company SYNTHESIS OF BICYCLO [2.2.2] OCTANE DERIVATIVES
SG11202003827YA (en) 2017-11-01 2020-05-28 Bristol Myers Squibb Co Bridged bicyclic compounds as farnesoid x receptor modulators
EP3765446A1 (en) 2018-03-15 2021-01-20 AXXAM S.p.A. Substituted pyrazoles ffa4/gpr120 receptor agonists
US10836899B2 (en) 2018-12-13 2020-11-17 Eastman Chemical Company Polyesters with specified crystallization half-times
EP4055024A1 (en) 2019-11-06 2022-09-14 Eastman Chemical Company Process for preparing bicyclo[2.2.2]octane-1,4-diol
CN113248438B (zh) * 2021-05-17 2022-04-12 浙大城市学院 一种吡唑类化合物及其制备方法

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US6008234A (en) * 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
EP2305684A1 (en) * 1999-11-12 2011-04-06 Biogen Idec MA Inc. Poycyloalkylpurines as adenosine receptor antagonists
UA80258C2 (en) * 2001-09-06 2007-09-10 Biogen Inc Methods of treating pulmonary disease
UA84404C2 (ru) * 2002-06-12 2008-10-27 Байоджен Айдек Ма Инк. Способ лечения ишемического реперфузионного повреждения с помощью антагонистов рецептора аденозина
ES2375625T3 (es) * 2004-02-05 2012-03-02 Kyorin Pharmaceutical Co., Ltd. Derivados de biciclo éster.
AR058562A1 (es) * 2005-12-22 2008-02-13 Astrazeneca Ab Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1
RU2468011C2 (ru) * 2006-12-27 2012-11-27 Санофи-Авентис Замещенные циклоалкиламином производные изохинолина и изохинолинона
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WO2013074387A1 (en) * 2011-11-14 2013-05-23 Merck Sharp & Dohme Corp. Imidazole derivatives
US8962660B2 (en) 2013-03-14 2015-02-24 Bristol-Myers Squibb Company Oxabicyclo [2.2.2] acid GPR120 modulators

Also Published As

Publication number Publication date
BR112015021386A2 (pt) 2017-07-18
US9598390B2 (en) 2017-03-21
EP2970172A1 (en) 2016-01-20
EA201591815A1 (ru) 2016-01-29
MX2015011932A (es) 2015-12-01
CN105209447A (zh) 2015-12-30
EP2970172B1 (en) 2019-10-30
CN105209447B (zh) 2017-11-21
KR20150130398A (ko) 2015-11-23
IL241318B (en) 2018-12-31
AU2014244482A1 (en) 2015-11-05
ES2765973T3 (es) 2020-06-11
SG11201506800YA (en) 2015-09-29
US20160039780A1 (en) 2016-02-11
IL241318A0 (en) 2015-11-30
JP2016516708A (ja) 2016-06-09
AU2014244482B2 (en) 2018-01-25
CA2905431A1 (en) 2014-10-02
WO2014159802A1 (en) 2014-10-02

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