JOP20190183B1 - معدِلات مستقبلات الاستروجين - Google Patents
معدِلات مستقبلات الاستروجينInfo
- Publication number
- JOP20190183B1 JOP20190183B1 JOP/2019/0183A JOP20190183A JOP20190183B1 JO P20190183 B1 JOP20190183 B1 JO P20190183B1 JO P20190183 A JOP20190183 A JO P20190183A JO P20190183 B1 JOP20190183 B1 JO P20190183B1
- Authority
- JO
- Jordan
- Prior art keywords
- estrogen receptor
- receptor modulators
- compounds
- processes
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
يتعلق الاختراع الحالي بمركبات بالصيغة (I) صورة (I) وبأملاح مقبولة صيدلانياً منها، بعمليات ومركبات وسيطة تستخدم لتحضيرها، بتركيبات صيدلانية تحتوي عليها وباستخدامها في معالجة اضطرابات التكاثر الخلوي. الصيغة I
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762451971P | 2017-01-30 | 2017-01-30 | |
US201762523695P | 2017-06-22 | 2017-06-22 | |
US201762560304P | 2017-09-19 | 2017-09-19 | |
US201762592485P | 2017-11-30 | 2017-11-30 | |
PCT/EP2018/052040 WO2018138303A1 (en) | 2017-01-30 | 2018-01-29 | Estrogen receptor modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
JOP20190183A1 JOP20190183A1 (ar) | 2019-07-28 |
JOP20190183B1 true JOP20190183B1 (ar) | 2022-09-15 |
Family
ID=61223883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2019/0183A JOP20190183B1 (ar) | 2017-01-30 | 2018-01-29 | معدِلات مستقبلات الاستروجين |
Country Status (36)
Country | Link |
---|---|
US (3) | US10221173B2 (ar) |
EP (2) | EP3689873B1 (ar) |
JP (1) | JP6951451B2 (ar) |
KR (1) | KR102246668B1 (ar) |
CN (1) | CN110214140B (ar) |
AU (1) | AU2018211495B2 (ar) |
BR (1) | BR112019015389A2 (ar) |
CA (1) | CA3050337A1 (ar) |
CL (1) | CL2019001991A1 (ar) |
CO (1) | CO2019008941A2 (ar) |
CR (1) | CR20190379A (ar) |
CY (1) | CY1122731T1 (ar) |
DK (1) | DK3494116T3 (ar) |
DO (1) | DOP2019000183A (ar) |
EC (1) | ECSP19062381A (ar) |
ES (2) | ES2931320T3 (ar) |
HU (1) | HUE047761T2 (ar) |
IL (1) | IL268263B (ar) |
JO (1) | JOP20190183B1 (ar) |
LT (1) | LT3494116T (ar) |
MA (1) | MA52555A (ar) |
MX (1) | MX2019008438A (ar) |
MY (1) | MY196317A (ar) |
NI (1) | NI201900080A (ar) |
PE (1) | PE20191500A1 (ar) |
PH (1) | PH12019501724A1 (ar) |
PL (1) | PL3494116T3 (ar) |
PT (1) | PT3494116T (ar) |
RS (1) | RS59770B1 (ar) |
SG (1) | SG11201906767XA (ar) |
SI (1) | SI3494116T1 (ar) |
TN (1) | TN2020000009A1 (ar) |
TW (1) | TWI794205B (ar) |
UA (1) | UA125043C2 (ar) |
WO (1) | WO2018138303A1 (ar) |
ZA (1) | ZA201904696B (ar) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3411034T3 (da) | 2016-02-05 | 2021-01-11 | Inventisbio Inc | Selektiv østrogenreceptornedbrydere og anvendelser deraf |
EP4086256A1 (en) | 2016-12-16 | 2022-11-09 | Janssen Pharmaceutica NV | Small molecule inhibitors of the jak family of kinases |
JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Jak激酶家族之小分子抑制劑 |
TW202126299A (zh) * | 2019-09-19 | 2021-07-16 | 美商托特斯藥品公司 | 治療性共軛物 |
CN115557920B (zh) * | 2022-09-22 | 2024-02-20 | 吉林奥来德光电材料股份有限公司 | 一种发光辅助材料、其制备方法及有机电致发光器件 |
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WO2005111208A1 (ja) * | 2004-04-27 | 2005-11-24 | Chugai Seiyaku Kabushiki Kaisha | プラズマ細胞の増殖方法 |
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FR2884252B1 (fr) | 2005-04-08 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90 |
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2018
- 2018-01-29 BR BR112019015389-6A patent/BR112019015389A2/pt active Search and Examination
- 2018-01-29 EP EP19203383.5A patent/EP3689873B1/en active Active
- 2018-01-29 MY MYPI2019004298A patent/MY196317A/en unknown
- 2018-01-29 ES ES19203383T patent/ES2931320T3/es active Active
- 2018-01-29 DK DK18705097.6T patent/DK3494116T3/da active
- 2018-01-29 CA CA3050337A patent/CA3050337A1/en active Pending
- 2018-01-29 CN CN201880008715.8A patent/CN110214140B/zh active Active
- 2018-01-29 RS RS20200018A patent/RS59770B1/sr unknown
- 2018-01-29 MX MX2019008438A patent/MX2019008438A/es unknown
- 2018-01-29 AU AU2018211495A patent/AU2018211495B2/en active Active
- 2018-01-29 CR CR20190379A patent/CR20190379A/es unknown
- 2018-01-29 TW TW107103088A patent/TWI794205B/zh active
- 2018-01-29 SG SG11201906767XA patent/SG11201906767XA/en unknown
- 2018-01-29 PE PE2019001434A patent/PE20191500A1/es unknown
- 2018-01-29 SI SI201830022T patent/SI3494116T1/sl unknown
- 2018-01-29 KR KR1020197025253A patent/KR102246668B1/ko active IP Right Grant
- 2018-01-29 UA UAA201909412A patent/UA125043C2/uk unknown
- 2018-01-29 EP EP18705097.6A patent/EP3494116B1/en active Active
- 2018-01-29 WO PCT/EP2018/052040 patent/WO2018138303A1/en unknown
- 2018-01-29 MA MA052555A patent/MA52555A/fr unknown
- 2018-01-29 JP JP2019538615A patent/JP6951451B2/ja active Active
- 2018-01-29 PL PL18705097T patent/PL3494116T3/pl unknown
- 2018-01-29 LT LTEP18705097.6T patent/LT3494116T/lt unknown
- 2018-01-29 TN TNP/2020/000009A patent/TN2020000009A1/en unknown
- 2018-01-29 JO JOP/2019/0183A patent/JOP20190183B1/ar active
- 2018-01-29 PT PT187050976T patent/PT3494116T/pt unknown
- 2018-01-29 ES ES18705097T patent/ES2766249T3/es active Active
- 2018-01-29 US US15/881,962 patent/US10221173B2/en active Active
- 2018-01-29 HU HUE18705097A patent/HUE047761T2/hu unknown
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2019
- 2019-01-31 US US16/263,683 patent/US10590132B2/en active Active
- 2019-07-15 CL CL2019001991A patent/CL2019001991A1/es unknown
- 2019-07-16 DO DO2019000183A patent/DOP2019000183A/es unknown
- 2019-07-17 ZA ZA2019/04696A patent/ZA201904696B/en unknown
- 2019-07-25 IL IL268263A patent/IL268263B/en unknown
- 2019-07-26 NI NI201900080A patent/NI201900080A/es unknown
- 2019-07-26 PH PH12019501724A patent/PH12019501724A1/en unknown
- 2019-08-16 CO CONC2019/0008941A patent/CO2019008941A2/es unknown
- 2019-08-28 EC ECSENADI201962381A patent/ECSP19062381A/es unknown
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2020
- 2020-01-08 CY CY20201100014T patent/CY1122731T1/el unknown
- 2020-01-29 US US16/775,781 patent/US11046689B2/en active Active
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