MX9604687A - Procedimiento para la preparacion de derivados de imidazo-benzodiacepina. - Google Patents

Procedimiento para la preparacion de derivados de imidazo-benzodiacepina.

Info

Publication number
MX9604687A
MX9604687A MX9604687A MX9604687A MX9604687A MX 9604687 A MX9604687 A MX 9604687A MX 9604687 A MX9604687 A MX 9604687A MX 9604687 A MX9604687 A MX 9604687A MX 9604687 A MX9604687 A MX 9604687A
Authority
MX
Mexico
Prior art keywords
imidazo
lower alkyl
hydrogen
preparation
compounds
Prior art date
Application number
MX9604687A
Other languages
English (en)
Inventor
Karl-Heinz Bender
Manfred Breuninger
Manfred Froom
Siegfried Schmitt
Kurt Steiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX9604687A publication Critical patent/MX9604687A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

El invento se refiere a un nuevo procedimiento para la preparacion de derivados de 4H-imidazo[1,5-a][1,4]benzodiacepina de la formula general (I), en donde; R1 significa fenilo o fenilo mono- o disustituido; R2 significa hidrogeno, halogeno, nitro, ciano, trifluorometilo o alquilo inferior; R3 significa hidrogeno o alquilo inferior; y R4 significa hidrogeno o alquilo inferior y las sales farmacéuticamente utilizables de estos compuestos mediante la descarboxilacion del ácido 4H-imidazo[1,5-a][,4]-benzodiacepincarboxílico de la formula general (II), en donde; R1, R2, R3, y R4 tienen el significado antes indicado, a temperatura elevada y bajo presion elevada en presencia de un disolvente orgánico. Los compuestos de formula I y sus sales de adicion deácido farmacéuticamente utilizables son relajantes musculares, sedantes y anticonvulsivos conocidos.
MX9604687A 1995-10-10 1996-10-09 Procedimiento para la preparacion de derivados de imidazo-benzodiacepina. MX9604687A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH285495 1995-10-10

Publications (1)

Publication Number Publication Date
MX9604687A true MX9604687A (es) 1997-04-30

Family

ID=4243076

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9604687A MX9604687A (es) 1995-10-10 1996-10-09 Procedimiento para la preparacion de derivados de imidazo-benzodiacepina.

Country Status (14)

Country Link
US (1) US5693795A (es)
EP (1) EP0768310B1 (es)
JP (1) JP3007050B2 (es)
CN (1) CN1060776C (es)
AR (1) AR003800A1 (es)
AT (1) ATE187727T1 (es)
BR (1) BR9605030A (es)
CA (1) CA2184802C (es)
DE (1) DE59603916D1 (es)
DK (1) DK0768310T3 (es)
ES (1) ES2141428T3 (es)
GR (1) GR3032600T3 (es)
MX (1) MX9604687A (es)
TR (1) TR199600779A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6512114B1 (en) * 1999-06-30 2003-01-28 Abbott Laboratories Process for the preparation of Midazolam
US6262260B1 (en) * 2000-03-23 2001-07-17 Abbott Laboratories Process for the preparation of midazolam
JP4298212B2 (ja) * 2002-03-29 2009-07-15 大日本印刷株式会社 塩酸エピナスチン高融点型結晶の製造法
CA2706512C (en) * 2008-02-08 2013-12-24 Colgate-Palmolive Company Compositions and devices
AU2009212335B2 (en) * 2008-02-08 2011-12-01 Colgate-Palmolive Company Compositions comprising basic amino acid and soluble carbonate salt
US20110044914A1 (en) * 2008-02-08 2011-02-24 Colgate -Palmolive Company Cleaning compositions and methods
CN101938970A (zh) * 2008-02-08 2011-01-05 高露洁-棕榄公司 牙齿密封剂
BRPI0906462A2 (pt) * 2008-02-08 2015-07-14 Colgate Palmolive Co Método para tratar, melhorar, inibir ou evitar boca seca, saliva artificial, uso de um aminoácido básico em forma livre ou de sal, e, aminoácido básico em forma livre ou de sal
BRPI0906464A2 (pt) 2008-02-08 2015-07-14 Colgate Palmolive Co Fio dental, embalagem para armazenar ou dispensar fio dental, e, métodos para produzir fio dental e para tratar um condição
CA2706505C (en) * 2008-02-08 2014-11-18 Colgate-Palmolive Company Effervescent compositions
AR070592A1 (es) * 2008-02-08 2010-04-21 Colgate Palmolive Co Composiciones para el blanqueamiento dental
WO2009100285A1 (en) * 2008-02-08 2009-08-13 Colgate-Palmolive Company Oral care toothbrush
US20100330002A1 (en) * 2008-02-08 2010-12-30 Colgate-Palmolive Company Compositions and methods comprising basic amino acid peptides and proteases
IT1399764B1 (it) * 2010-05-04 2013-05-03 F S I Fabbrica Italiana Sint Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam.
UA110640C2 (uk) * 2011-05-05 2016-01-25 Янссен Фармацевтика Нв ПРОТИГРИБКОВІ 5,6-ДИГІДРО-4Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ ТА 6Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ, ЯКІ ЗАМІЩЕНІ ГЕТЕРОЦИКЛІЧНИМИ ПОХІДНИМИ
BR112019003065A2 (pt) 2016-08-16 2019-05-21 The Trustees Of Columbia University In The City Of New York moduladores do receptor gaba(a) e métodos para o controle da hiper-responsividade das vias respiratórias e inflamação na asma
CN113603635B (zh) * 2021-10-08 2021-12-24 湖南速博生物技术有限公司 一种芳香族二元羧酸酯水解脱羧的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307237A (en) * 1974-09-11 1981-12-22 Hoffmann-La Roche Inc. Imidazoles
US4280957A (en) * 1974-09-11 1981-07-28 Hoffmann-La Roche Inc. Imidazodiazepines and processes therefor
DE2609486A1 (de) * 1975-08-07 1977-05-12 Hoffmann La Roche Imidazo eckige klammer auf 1,5-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu diazepin-verbindungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0768310B1 (de) 1999-12-15
TR199600779A2 (tr) 1997-04-22
US5693795A (en) 1997-12-02
CA2184802C (en) 2007-07-31
DE59603916D1 (de) 2000-01-20
EP0768310A1 (de) 1997-04-16
CA2184802A1 (en) 1997-04-11
GR3032600T3 (en) 2000-05-31
JP3007050B2 (ja) 2000-02-07
CN1060776C (zh) 2001-01-17
DK0768310T3 (da) 2000-04-17
ES2141428T3 (es) 2000-03-16
JPH09110871A (ja) 1997-04-28
BR9605030A (pt) 1998-06-30
AR003800A1 (es) 1998-09-09
ATE187727T1 (de) 2000-01-15
CN1150152A (zh) 1997-05-21

Similar Documents

Publication Publication Date Title
MX9604687A (es) Procedimiento para la preparacion de derivados de imidazo-benzodiacepina.
ATE246190T1 (de) Heterozyklische verbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen die diese enthalten und ihre anwendung in der behandlung von diabetis und verwandten krankheiten
HUP0100615A2 (hu) Szubsztituált 2-(2,6-dioxo-3-fluoro-piperidin-3-il)-izoindolinok és ezek alkalmazása TNFalfa-szint csökkentésére
NO153220C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolinderivater.
ATE163012T1 (de) N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel
NZ330973A (en) Azolobenzazepine derivatives as neurologically active agents
TW341565B (en) Indole derivatives processes and intermediates for their preparation and pharmaceutical compositions containing them
BG101769A (en) Indole derivatives useful in the treatment of osteoporosis
FI961914A (fi) Lyhytvaikutteiset dihydropyridiinit
CA2244777A1 (en) 2,3-benzodiazepine derivatives and their use as ampa-receptor inhibitors
HUP0003577A2 (hu) Tetrahidro-gamma-karbolinok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
NZ336189A (en) Diaza-spiro[3,5]nonane derivatives and use in treatment of diseases related to the orphanin receptor
HK1115728A1 (en) Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
HUP9700708A2 (hu) N-[(9-pirimido[1,2-a]indolil)-metil-fenil-acetil]-fenil-glicinol-származékok, az ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra és intermedierjeik
ES2016017A6 (es) Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico.
AU2502997A (en) New 2,3-benzodiazepine derivatives, their production and use as pharmaceutical agents
GR3031407T3 (en) IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME
IL108290A0 (en) Pyrrolidine derivatives, their preparation and medicaments containing them
IL111404A0 (en) 3-aryl-4-alkyl and 4,5-dialkyl-4h-1, 2, 4-triazoles useful as memory enhancers
HUP9900916A2 (hu) Benzotiofénszármazékok felhasználása az érszövetek kalciumvezetékeit antagonizáló hatású gyógyszerkészítmények előállítására
CA1251790A (en) PYRROLE[1,2-B][1,2,5] TRIAZEPINES, METHOD AND INTERMEDIATES FOR THEIR PREPARATION AND USE AS MEDICINES
ES2120039T3 (es) Nuevos acildipeptidos heterociclicos, procedimientos de preparacion y composiciones farmaceuticas que los contienen.
ATE283834T1 (de) Phenantrenderivate mit medizinischer anwendung sowie dessen herstellungsverfahren