HUP9900916A2 - Benzotiofénszármazékok felhasználása az érszövetek kalciumvezetékeit antagonizáló hatású gyógyszerkészítmények előállítására - Google Patents

Benzotiofénszármazékok felhasználása az érszövetek kalciumvezetékeit antagonizáló hatású gyógyszerkészítmények előállítására

Info

Publication number
HUP9900916A2
HUP9900916A2 HU9900916A HUP9900916A HUP9900916A2 HU P9900916 A2 HUP9900916 A2 HU P9900916A2 HU 9900916 A HU9900916 A HU 9900916A HU P9900916 A HUP9900916 A HU P9900916A HU P9900916 A2 HUP9900916 A2 HU P9900916A2
Authority
HU
Hungary
Prior art keywords
general formula
production
medicaments
calcium channel
antagonistic activity
Prior art date
Application number
HU9900916A
Other languages
English (en)
Inventor
Marlene L. Cohen
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP9900916A2 publication Critical patent/HUP9900916A2/hu
Publication of HUP9900916A3 publication Critical patent/HUP9900916A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Eljárás az érszövetekben lévő kalciűmvezetékek antagőnizálására vagyblőkkőlására alkalmas gyógyszerkészítmény előállítására, amely (I)általánős képletű vegyületet tartalmaz, ahől az (I) általánősképletben R1 és R3 jelentése egymástól függetlenül hidrőgénatőm, 1-4 szénatőmősalkil-, -CO(1-6 szénatőmős-alkil)- vagy -CH2Ar-, -CO-Ar csőpőrt, ahőlAr jelentése adőtt esetben szűbsztitűált fenilcsőpőrt, R2 jelentése pirrőlidinő-, hexametilén-iminő- vagy piperidinőcsőpőrt.A találmány szerinti készítménnyel szívrendellenességeket, ígyanginát, a szívizőm ischémiás eredetű kárősődását, arrythmiát, agyér-rendellenességeket kezelnek. A találmány tárgyáhőz tartőzik az (I)általánős képletű vegyületek alkalmazása is, amelyek sőrán az (I)általánős képletű vegyületeket gyógyászati készítménnyé alakítják. ŕ
HU9900916A 1995-06-07 1996-06-04 Use of benzotiophene derivatives for the production of medicaments having calcium channel antagonistic activity HUP9900916A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/485,406 US5840747A (en) 1995-06-07 1995-06-07 Calcium channel antagonists

Publications (2)

Publication Number Publication Date
HUP9900916A2 true HUP9900916A2 (hu) 1999-09-28
HUP9900916A3 HUP9900916A3 (en) 1999-11-29

Family

ID=23928032

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900916A HUP9900916A3 (en) 1995-06-07 1996-06-04 Use of benzotiophene derivatives for the production of medicaments having calcium channel antagonistic activity

Country Status (21)

Country Link
US (1) US5840747A (hu)
EP (1) EP0831822B1 (hu)
JP (1) JPH11506788A (hu)
KR (1) KR19990022499A (hu)
CN (1) CN1193274A (hu)
AT (1) ATE252902T1 (hu)
AU (1) AU714403B2 (hu)
CA (1) CA2223711A1 (hu)
CZ (1) CZ288546B6 (hu)
DE (1) DE69630523T2 (hu)
EA (1) EA001928B1 (hu)
ES (1) ES2210373T3 (hu)
HU (1) HUP9900916A3 (hu)
IL (1) IL122459A (hu)
MX (1) MX9709468A (hu)
NO (1) NO975561L (hu)
NZ (1) NZ310178A (hu)
PL (1) PL183998B1 (hu)
RO (1) RO116344B1 (hu)
UA (1) UA43895C2 (hu)
WO (1) WO1996040134A1 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008232A (en) * 1997-08-20 1999-12-28 Eli Lilly And Company Methods for preventing headaches
AU7896100A (en) * 1999-10-14 2001-04-23 Endorecherche Inc. Selective estrogen receptor modulators in the treatment or reduction of the riskof acquiring hypertension, cardiovascular diseases, and insulin resistance
EP1113007A1 (en) 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US5447941A (en) * 1993-12-21 1995-09-05 Eli Lilly And Company Methods of inhibiting pulmonary hypertensive diseases with raloxifene and related benzothiophenes
US5441965A (en) * 1993-12-21 1995-08-15 Eli Lilly And Company Methods of inhibiting thrombin
US6562862B1 (en) * 1994-10-20 2003-05-13 Eli Lilly And Company Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
US5532254A (en) * 1995-06-07 1996-07-02 Eli Lilly And Company Modulation of calcium channels using benzothiophenes

Also Published As

Publication number Publication date
ES2210373T3 (es) 2004-07-01
NO975561D0 (no) 1997-12-02
DE69630523D1 (de) 2003-12-04
JPH11506788A (ja) 1999-06-15
MX9709468A (es) 1998-04-30
EP0831822A4 (en) 2001-12-19
EP0831822A1 (en) 1998-04-01
NO975561L (no) 1997-12-02
IL122459A0 (en) 1998-06-15
CA2223711A1 (en) 1996-12-19
EA199800033A1 (ru) 1998-06-25
WO1996040134A1 (en) 1996-12-19
PL324086A1 (en) 1998-05-11
PL183998B1 (pl) 2002-08-30
AU6091996A (en) 1996-12-30
HUP9900916A3 (en) 1999-11-29
UA43895C2 (uk) 2002-01-15
CZ382897A3 (cs) 1999-01-13
CZ288546B6 (cs) 2001-07-11
EP0831822B1 (en) 2003-10-29
CN1193274A (zh) 1998-09-16
ATE252902T1 (de) 2003-11-15
EA001928B1 (ru) 2001-10-22
NZ310178A (en) 2000-06-23
AU714403B2 (en) 2000-01-06
IL122459A (en) 2001-05-20
DE69630523T2 (de) 2004-08-12
RO116344B1 (ro) 2001-01-30
US5840747A (en) 1998-11-24
KR19990022499A (ko) 1999-03-25

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