NO169442C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive prolinderivater og lignende forbindelser - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive prolinderivater og lignende forbindelser

Info

Publication number
NO169442C
NO169442C NO853551A NO853551A NO169442C NO 169442 C NO169442 C NO 169442C NO 853551 A NO853551 A NO 853551A NO 853551 A NO853551 A NO 853551A NO 169442 C NO169442 C NO 169442C
Authority
NO
Norway
Prior art keywords
preparation
therapeutically active
similar compounds
proline derivatives
analogy procedure
Prior art date
Application number
NO853551A
Other languages
English (en)
Other versions
NO853551L (no
NO169442B (no
Inventor
Edward S Neiss
John T Suh
John R Regan
Jerry W Skiles
Jeffrey N Barton
Paul Menard
James J Mencel
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/649,797 external-priority patent/US4746676A/en
Priority claimed from US06/752,695 external-priority patent/US4749698A/en
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Publication of NO853551L publication Critical patent/NO853551L/no
Publication of NO169442B publication Critical patent/NO169442B/no
Publication of NO169442C publication Critical patent/NO169442C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
NO853551A 1984-09-12 1985-09-11 Analogifremgangsmaate ved fremstilling av terapeutisk aktive prolinderivater og lignende forbindelser NO169442C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/649,797 US4746676A (en) 1984-09-12 1984-09-12 Carboxyalkyl dipeptide compounds
US06/752,695 US4749698A (en) 1985-07-08 1985-07-08 Antihypertensive derivatives

Publications (3)

Publication Number Publication Date
NO853551L NO853551L (no) 1986-03-13
NO169442B NO169442B (no) 1992-03-16
NO169442C true NO169442C (no) 1992-06-24

Family

ID=27095707

Family Applications (1)

Application Number Title Priority Date Filing Date
NO853551A NO169442C (no) 1984-09-12 1985-09-11 Analogifremgangsmaate ved fremstilling av terapeutisk aktive prolinderivater og lignende forbindelser

Country Status (13)

Country Link
EP (1) EP0175266B1 (no)
KR (1) KR860002464A (no)
AT (1) ATE135711T1 (no)
AU (1) AU578489B2 (no)
CA (1) CA1288893C (no)
DE (1) DE3588094T2 (no)
DK (1) DK412985A (no)
ES (1) ES8609364A1 (no)
FI (1) FI89716C (no)
IL (1) IL76345A (no)
IN (1) IN164615B (no)
NO (1) NO169442C (no)
NZ (1) NZ213432A (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
WO1995034577A1 (en) * 1994-06-16 1995-12-21 Smithkline Beecham Corporation Template directed cyclization
CA2388468C (en) † 1999-10-14 2011-01-25 Curis, Inc. Mediators of hedgehog signalling pathways, compositions and uses related thereto
DE50015940D1 (de) 2000-09-21 2010-07-29 Abb Schweiz Ag Konfiguration eines Leitsystems einer elektrischen Schaltanlage
AU2006332945C1 (en) 2005-12-23 2013-02-28 Wyeth Modified lysine-mimetic compounds
EP2074087A2 (en) 2006-12-21 2009-07-01 Wyeth Synthesis of pyrrolidine compounds
DK3618847T3 (da) 2017-05-05 2021-05-25 Boston Medical Ct Corp GAP-junction-modulatorer af intercellulær kommunikation og deres anvendelse til behandling af diabetisk øjensygdom

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
EP0048159A3 (en) * 1980-09-17 1982-05-12 University Of Miami Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
FR2501399B1 (fr) * 1981-03-03 1987-06-19 France Etat Dispositif d'affichage de messages graphiques transmis par des systemes de videotex
EP0080822A1 (en) * 1981-11-27 1983-06-08 Beecham Group Plc Anti-hypertensive prolinol-based peptides
DE3360065D1 (en) * 1982-03-08 1985-03-28 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
ZA832762B (en) * 1982-04-30 1983-12-28 Squibb & Sons Inc Substituted 4-phenoxy prolines
AU1643283A (en) * 1982-07-19 1984-01-26 E.R. Squibb & Sons, Inc. Substituted peptides
US4623729A (en) * 1982-07-22 1986-11-18 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
DK156484A (da) * 1983-03-16 1984-09-17 Usv Pharma Corp Aminosyrederivater
ZA843899B (en) * 1983-05-23 1984-12-24 Usv Pharma Corp Compounds for treating hypertension

Also Published As

Publication number Publication date
FI89716C (fi) 1993-11-10
KR860002464A (ko) 1986-04-26
ES8609364A1 (es) 1986-07-16
ES546866A0 (es) 1986-07-16
FI853494L (fi) 1986-03-13
EP0175266A2 (en) 1986-03-26
EP0175266A3 (en) 1988-08-03
DK412985A (da) 1986-03-13
FI89716B (fi) 1993-07-30
AU578489B2 (en) 1988-10-27
NZ213432A (en) 1988-11-29
EP0175266B1 (en) 1996-03-20
IL76345A (en) 1988-12-30
AU4733185A (en) 1986-03-20
IL76345A0 (en) 1986-01-31
FI853494A0 (fi) 1985-09-12
DE3588094D1 (de) 1996-04-25
DE3588094T2 (de) 1996-08-22
CA1288893C (en) 1991-09-10
NO853551L (no) 1986-03-13
DK412985D0 (da) 1985-09-11
ATE135711T1 (de) 1996-04-15
NO169442B (no) 1992-03-16
IN164615B (no) 1989-04-22

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