DE3588094D1 - Antihypertensive Derivate - Google Patents

Antihypertensive Derivate

Info

Publication number
DE3588094D1
DE3588094D1 DE3588094T DE3588094T DE3588094D1 DE 3588094 D1 DE3588094 D1 DE 3588094D1 DE 3588094 T DE3588094 T DE 3588094T DE 3588094 T DE3588094 T DE 3588094T DE 3588094 D1 DE3588094 D1 DE 3588094D1
Authority
DE
Germany
Prior art keywords
antihypertensive
derivatives
substituents
chem
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3588094T
Other languages
English (en)
Other versions
DE3588094T2 (de
Inventor
Edward S Neiss
John T Suh
John R Regan
Jerry W Skiles
Jeffrey N Barton
Paul Menard
James J Mencel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Rhone Poulenc Rorer Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/649,797 external-priority patent/US4746676A/en
Priority claimed from US06/752,695 external-priority patent/US4749698A/en
Application filed by Rhone Poulenc Rorer Pharmaceuticals Inc filed Critical Rhone Poulenc Rorer Pharmaceuticals Inc
Publication of DE3588094D1 publication Critical patent/DE3588094D1/de
Application granted granted Critical
Publication of DE3588094T2 publication Critical patent/DE3588094T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE3588094T 1984-09-12 1985-09-10 Antihypertensive Derivate Expired - Fee Related DE3588094T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/649,797 US4746676A (en) 1984-09-12 1984-09-12 Carboxyalkyl dipeptide compounds
US06/752,695 US4749698A (en) 1985-07-08 1985-07-08 Antihypertensive derivatives

Publications (2)

Publication Number Publication Date
DE3588094D1 true DE3588094D1 (de) 1996-04-25
DE3588094T2 DE3588094T2 (de) 1996-08-22

Family

ID=27095707

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3588094T Expired - Fee Related DE3588094T2 (de) 1984-09-12 1985-09-10 Antihypertensive Derivate

Country Status (13)

Country Link
EP (1) EP0175266B1 (de)
KR (1) KR860002464A (de)
AT (1) ATE135711T1 (de)
AU (1) AU578489B2 (de)
CA (1) CA1288893C (de)
DE (1) DE3588094T2 (de)
DK (1) DK412985A (de)
ES (1) ES8609364A1 (de)
FI (1) FI89716C (de)
IL (1) IL76345A (de)
IN (1) IN164615B (de)
NO (1) NO169442C (de)
NZ (1) NZ213432A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
WO1995034577A1 (en) * 1994-06-16 1995-12-21 Smithkline Beecham Corporation Template directed cyclization
CA2388468C (en) † 1999-10-14 2011-01-25 Curis, Inc. Mediators of hedgehog signalling pathways, compositions and uses related thereto
DE50015940D1 (de) 2000-09-21 2010-07-29 Abb Schweiz Ag Konfiguration eines Leitsystems einer elektrischen Schaltanlage
AU2006332945C1 (en) 2005-12-23 2013-02-28 Wyeth Modified lysine-mimetic compounds
EP2074087A2 (de) 2006-12-21 2009-07-01 Wyeth Synthese von pyrrolidinverbindungen
DK3618847T3 (da) 2017-05-05 2021-05-25 Boston Medical Ct Corp GAP-junction-modulatorer af intercellulær kommunikation og deres anvendelse til behandling af diabetisk øjensygdom

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
EP0048159A3 (de) * 1980-09-17 1982-05-12 University Of Miami Carboxyalkyl-Peptide und Thioäther und Äther von Peptiden als antihypertensive Mittel
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
FR2501399B1 (fr) * 1981-03-03 1987-06-19 France Etat Dispositif d'affichage de messages graphiques transmis par des systemes de videotex
EP0080822A1 (de) * 1981-11-27 1983-06-08 Beecham Group Plc Antihypertensive auf Prolin basierende Peptide
DE3360065D1 (en) * 1982-03-08 1985-03-28 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
ZA832762B (en) * 1982-04-30 1983-12-28 Squibb & Sons Inc Substituted 4-phenoxy prolines
AU1643283A (en) * 1982-07-19 1984-01-26 E.R. Squibb & Sons, Inc. Substituted peptides
US4623729A (en) * 1982-07-22 1986-11-18 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
DK156484A (da) * 1983-03-16 1984-09-17 Usv Pharma Corp Aminosyrederivater
ZA843899B (en) * 1983-05-23 1984-12-24 Usv Pharma Corp Compounds for treating hypertension

Also Published As

Publication number Publication date
FI89716C (fi) 1993-11-10
KR860002464A (ko) 1986-04-26
ES8609364A1 (es) 1986-07-16
ES546866A0 (es) 1986-07-16
FI853494L (fi) 1986-03-13
EP0175266A2 (de) 1986-03-26
NO169442C (no) 1992-06-24
EP0175266A3 (en) 1988-08-03
DK412985A (da) 1986-03-13
FI89716B (fi) 1993-07-30
AU578489B2 (en) 1988-10-27
NZ213432A (en) 1988-11-29
EP0175266B1 (de) 1996-03-20
IL76345A (en) 1988-12-30
AU4733185A (en) 1986-03-20
IL76345A0 (en) 1986-01-31
FI853494A0 (fi) 1985-09-12
DE3588094T2 (de) 1996-08-22
CA1288893C (en) 1991-09-10
NO853551L (no) 1986-03-13
DK412985D0 (da) 1985-09-11
ATE135711T1 (de) 1996-04-15
NO169442B (no) 1992-03-16
IN164615B (de) 1989-04-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee