DK412985A - Prolinforbindelse og farmaceutisk praeparat indeholdende forbindelsen - Google Patents

Prolinforbindelse og farmaceutisk praeparat indeholdende forbindelsen

Info

Publication number
DK412985A
DK412985A DK412985A DK412985A DK412985A DK 412985 A DK412985 A DK 412985A DK 412985 A DK412985 A DK 412985A DK 412985 A DK412985 A DK 412985A DK 412985 A DK412985 A DK 412985A
Authority
DK
Denmark
Prior art keywords
connection
proline
pharmaceutical preparation
preparation containing
substituents
Prior art date
Application number
DK412985A
Other languages
Danish (da)
English (en)
Other versions
DK412985D0 (da
Inventor
Edward S Neiss
John T Suh
John R Regan
Jerry W Skiles
Jeffrey N Barton
Paul Menard
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/649,797 external-priority patent/US4746676A/en
Priority claimed from US06/752,695 external-priority patent/US4749698A/en
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Publication of DK412985D0 publication Critical patent/DK412985D0/da
Publication of DK412985A publication Critical patent/DK412985A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK412985A 1984-09-12 1985-09-11 Prolinforbindelse og farmaceutisk praeparat indeholdende forbindelsen DK412985A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/649,797 US4746676A (en) 1984-09-12 1984-09-12 Carboxyalkyl dipeptide compounds
US06/752,695 US4749698A (en) 1985-07-08 1985-07-08 Antihypertensive derivatives

Publications (2)

Publication Number Publication Date
DK412985D0 DK412985D0 (da) 1985-09-11
DK412985A true DK412985A (da) 1986-03-13

Family

ID=27095707

Family Applications (1)

Application Number Title Priority Date Filing Date
DK412985A DK412985A (da) 1984-09-12 1985-09-11 Prolinforbindelse og farmaceutisk praeparat indeholdende forbindelsen

Country Status (13)

Country Link
EP (1) EP0175266B1 (de)
KR (1) KR860002464A (de)
AT (1) ATE135711T1 (de)
AU (1) AU578489B2 (de)
CA (1) CA1288893C (de)
DE (1) DE3588094T2 (de)
DK (1) DK412985A (de)
ES (1) ES8609364A1 (de)
FI (1) FI89716C (de)
IL (1) IL76345A (de)
IN (1) IN164615B (de)
NO (1) NO169442C (de)
NZ (1) NZ213432A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
EP0765341A4 (de) * 1994-06-16 1998-09-16 Smithkline Beecham Corp Matrizen-dirigierte cyclisierung
JP4898044B2 (ja) † 1999-10-14 2012-03-14 キュリス，インコーポレイテッド ヘッジホッグシグナル伝達経路のメディエーター、それらと関連する組成物及び利用
DE50015940D1 (de) 2000-09-21 2010-07-29 Abb Schweiz Ag Konfiguration eines Leitsystems einer elektrischen Schaltanlage
KR101397915B1 (ko) * 2005-12-23 2014-05-26 와이어쓰 엘엘씨 개질된 리신 모방 화합물
DK2468724T3 (en) 2006-12-21 2016-02-22 Zealand Pharma As Synthesis of pyrrolidine compounds
JP6989864B2 (ja) 2017-05-05 2022-02-03 ジーランド ファーマ，アー／エス ギャップ結合細胞間コミュニケーションモジュレータ及び糖尿病性眼疾患の治療のためのそれらの使用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
GR75019B (de) * 1980-09-17 1984-07-12 Univ Miami
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
FR2501399B1 (fr) * 1981-03-03 1987-06-19 France Etat Dispositif d'affichage de messages graphiques transmis par des systemes de videotex
EP0080822A1 (de) * 1981-11-27 1983-06-08 Beecham Group Plc Antihypertensive auf Prolin basierende Peptide
DE3360065D1 (en) * 1982-03-08 1985-03-28 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
ZA832762B (en) * 1982-04-30 1983-12-28 Squibb & Sons Inc Substituted 4-phenoxy prolines
IL69136A0 (en) * 1982-07-19 1983-10-31 Squibb & Sons Inc Substituted peptide compounds
US4623729A (en) * 1982-07-22 1986-11-18 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
DK156484A (da) * 1983-03-16 1984-09-17 Usv Pharma Corp Aminosyrederivater
ZA843899B (en) * 1983-05-23 1984-12-24 Usv Pharma Corp Compounds for treating hypertension

Also Published As

Publication number Publication date
DE3588094T2 (de) 1996-08-22
CA1288893C (en) 1991-09-10
ES546866A0 (es) 1986-07-16
AU578489B2 (en) 1988-10-27
EP0175266A3 (en) 1988-08-03
ATE135711T1 (de) 1996-04-15
EP0175266B1 (de) 1996-03-20
IL76345A0 (en) 1986-01-31
EP0175266A2 (de) 1986-03-26
FI853494A0 (fi) 1985-09-12
DK412985D0 (da) 1985-09-11
NO853551L (no) 1986-03-13
AU4733185A (en) 1986-03-20
NZ213432A (en) 1988-11-29
NO169442B (no) 1992-03-16
NO169442C (no) 1992-06-24
IL76345A (en) 1988-12-30
IN164615B (de) 1989-04-22
FI89716C (fi) 1993-11-10
ES8609364A1 (es) 1986-07-16
DE3588094D1 (de) 1996-04-25
FI89716B (fi) 1993-07-30
FI853494L (fi) 1986-03-13
KR860002464A (ko) 1986-04-26

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment