FI853494A0 - Derivat med antihypertensiv verkan. - Google Patents

Derivat med antihypertensiv verkan.

Info

Publication number
FI853494A0
FI853494A0 FI853494A FI853494A FI853494A0 FI 853494 A0 FI853494 A0 FI 853494A0 FI 853494 A FI853494 A FI 853494A FI 853494 A FI853494 A FI 853494A FI 853494 A0 FI853494 A0 FI 853494A0
Authority
FI
Finland
Prior art keywords
derivated
hypertensive
network
substituents
chem
Prior art date
Application number
FI853494A
Other languages
English (en)
Other versions
FI89716C (fi
FI853494L (fi
FI89716B (fi
Inventor
Edward S Neiss
John T Suh
John R Regan
Jerry W Skiles
Jeffrey N Barton
Paul Menard
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/649,797 external-priority patent/US4746676A/en
Priority claimed from US06/752,695 external-priority patent/US4749698A/en
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Publication of FI853494A0 publication Critical patent/FI853494A0/fi
Publication of FI853494L publication Critical patent/FI853494L/fi
Application granted granted Critical
Publication of FI89716B publication Critical patent/FI89716B/fi
Publication of FI89716C publication Critical patent/FI89716C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI853494A 1984-09-12 1985-09-12 Foerfarande foer framstaellning av terapeutiskt aktiva prolinderivat FI89716C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64979784 1984-09-12
US06/649,797 US4746676A (en) 1984-09-12 1984-09-12 Carboxyalkyl dipeptide compounds
US06/752,695 US4749698A (en) 1985-07-08 1985-07-08 Antihypertensive derivatives
US75269585 1985-07-08

Publications (4)

Publication Number Publication Date
FI853494A0 true FI853494A0 (fi) 1985-09-12
FI853494L FI853494L (fi) 1986-03-13
FI89716B FI89716B (fi) 1993-07-30
FI89716C FI89716C (fi) 1993-11-10

Family

ID=27095707

Family Applications (1)

Application Number Title Priority Date Filing Date
FI853494A FI89716C (fi) 1984-09-12 1985-09-12 Foerfarande foer framstaellning av terapeutiskt aktiva prolinderivat

Country Status (13)

Country Link
EP (1) EP0175266B1 (fi)
KR (1) KR860002464A (fi)
AT (1) ATE135711T1 (fi)
AU (1) AU578489B2 (fi)
CA (1) CA1288893C (fi)
DE (1) DE3588094T2 (fi)
DK (1) DK412985A (fi)
ES (1) ES8609364A1 (fi)
FI (1) FI89716C (fi)
IL (1) IL76345A (fi)
IN (1) IN164615B (fi)
NO (1) NO169442C (fi)
NZ (1) NZ213432A (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
WO1995034577A1 (en) * 1994-06-16 1995-12-21 Smithkline Beecham Corporation Template directed cyclization
ATE324876T1 (de) † 1999-10-14 2006-06-15 Curis Inc VERMITTLER VON ßHEDGEHOGß ÜBERMITTELNDEN BAHNEN, DAZUGEHÖRIGE ZUSAMMENETZUNGEN UND VERWENDUNGEN
DE50015940D1 (de) 2000-09-21 2010-07-29 Abb Schweiz Ag Konfiguration eines Leitsystems einer elektrischen Schaltanlage
WO2007078990A2 (en) * 2005-12-23 2007-07-12 Zealand Pharma A/S Modified lysine-mimetic compounds
EP2074087A2 (en) 2006-12-21 2009-07-01 Wyeth Synthesis of pyrrolidine compounds
CN110709096B (zh) 2017-05-05 2023-10-31 泽兰德制药公司 细胞间隙连接通讯调节剂及其在糖尿病性眼病治疗中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
EP0048159A3 (en) * 1980-09-17 1982-05-12 University Of Miami Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
FR2501399B1 (fr) * 1981-03-03 1987-06-19 France Etat Dispositif d'affichage de messages graphiques transmis par des systemes de videotex
EP0080822A1 (en) * 1981-11-27 1983-06-08 Beecham Group Plc Anti-hypertensive prolinol-based peptides
EP0088350B1 (en) * 1982-03-08 1985-02-20 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
ZA832762B (en) * 1982-04-30 1983-12-28 Squibb & Sons Inc Substituted 4-phenoxy prolines
IL69136A0 (en) * 1982-07-19 1983-10-31 Squibb & Sons Inc Substituted peptide compounds
US4623729A (en) * 1982-07-22 1986-11-18 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
FI841052A (fi) * 1983-03-16 1984-09-17 Usv Pharma Corp Foereningar foer behandling av blodtryckssjukdomar.
EP0127124A3 (en) * 1983-05-23 1987-04-08 Usv Pharmaceutical Corporation Compounds for treating hypertension

Also Published As

Publication number Publication date
ATE135711T1 (de) 1996-04-15
CA1288893C (en) 1991-09-10
NO853551L (no) 1986-03-13
KR860002464A (ko) 1986-04-26
DK412985D0 (da) 1985-09-11
NO169442C (no) 1992-06-24
DK412985A (da) 1986-03-13
DE3588094D1 (de) 1996-04-25
IN164615B (fi) 1989-04-22
FI89716C (fi) 1993-11-10
FI853494L (fi) 1986-03-13
EP0175266A2 (en) 1986-03-26
AU4733185A (en) 1986-03-20
FI89716B (fi) 1993-07-30
NZ213432A (en) 1988-11-29
ES546866A0 (es) 1986-07-16
AU578489B2 (en) 1988-10-27
EP0175266A3 (en) 1988-08-03
ES8609364A1 (es) 1986-07-16
IL76345A0 (en) 1986-01-31
EP0175266B1 (en) 1996-03-20
NO169442B (no) 1992-03-16
IL76345A (en) 1988-12-30
DE3588094T2 (de) 1996-08-22

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: RHONE-POULENC RORER PHARMACEUTICALS,INC.

BB Publication of examined application
TC Name/ company changed in patent

Owner name: RHONE-POULENC RORER PHARMACEUTICALS,INC.

MM Patent lapsed
MM Patent lapsed

Owner name: RHONE-POULENC RORER PHARMACEUTICALS,_INC.