FR2401159A1 - Derives de 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidine-4-one, leur procede de preparation et leur activite therapeutique - Google Patents

Derives de 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidine-4-one, leur procede de preparation et leur activite therapeutique

Info

Publication number
FR2401159A1
FR2401159A1 FR7815398A FR7815398A FR2401159A1 FR 2401159 A1 FR2401159 A1 FR 2401159A1 FR 7815398 A FR7815398 A FR 7815398A FR 7815398 A FR7815398 A FR 7815398A FR 2401159 A1 FR2401159 A1 FR 2401159A1
Authority
FR
France
Prior art keywords
tetrazol
pyrido
pyrimidine
derivatives
preparation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7815398A
Other languages
English (en)
Other versions
FR2401159B1 (fr
Inventor
Peter Frederick Juby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2401159A1 publication Critical patent/FR2401159A1/fr
Application granted granted Critical
Publication of FR2401159B1 publication Critical patent/FR2401159B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La présente invention a pour objet, à titre de produits industriels nouveaux, de nouveaux composés, ainsi que leurs sels pharmaceutiquement acceptables. Ces nouveaux composés presentent la formule :
FR7815398A 1977-05-25 1978-05-24 Derives de 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidine-4-one, leur procede de preparation et leur activite therapeutique Granted FR2401159A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/800,264 US4122274A (en) 1977-05-25 1977-05-25 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones

Publications (2)

Publication Number Publication Date
FR2401159A1 true FR2401159A1 (fr) 1979-03-23
FR2401159B1 FR2401159B1 (fr) 1983-05-20

Family

ID=25177928

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7815398A Granted FR2401159A1 (fr) 1977-05-25 1978-05-24 Derives de 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidine-4-one, leur procede de preparation et leur activite therapeutique

Country Status (26)

Country Link
US (1) US4122274A (fr)
JP (1) JPS6050197B2 (fr)
AT (1) AT365187B (fr)
AU (1) AU521211B2 (fr)
BE (1) BE867295A (fr)
CA (1) CA1098520A (fr)
CH (1) CH642656A5 (fr)
CY (1) CY1218A (fr)
DE (1) DE2822544A1 (fr)
DK (1) DK160279C (fr)
FI (1) FI64594C (fr)
FR (1) FR2401159A1 (fr)
GB (1) GB1596476A (fr)
GR (1) GR71887B (fr)
HK (1) HK25884A (fr)
IE (1) IE46849B1 (fr)
IT (1) IT1105040B (fr)
KE (1) KE3357A (fr)
LU (1) LU79694A1 (fr)
MY (1) MY8500305A (fr)
NL (1) NL190702C (fr)
NO (1) NO150361C (fr)
SE (1) SE437830B (fr)
SG (1) SG73383G (fr)
YU (2) YU42163B (fr)
ZA (1) ZA782816B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2423490A1 (fr) * 1978-04-03 1979-11-16 Bristol Myers Co Nouveaux 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-n-(1h-tetrazol-5-yl) carboxamides eventuellement substitues, leur procede de production et medicament les contenant
FR2424924A1 (fr) * 1978-05-05 1979-11-30 Bristol Myers Co Nouvelles azolopyrimidinones, leur procede de production et medicament les contenant

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495189A (en) * 1975-11-27 1985-01-22 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. Condensed pyrimidines
HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom
HU180439B (en) * 1977-12-29 1983-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 9-amino-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives
US4491587A (en) * 1978-05-05 1985-01-01 Mead Johnson & Company Tetrazole derivatives
US4282360A (en) * 1979-10-12 1981-08-04 Hoffmann-La Roche Inc. 7-Methylthio or methylsulfinyl-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
US4419357A (en) * 1982-01-18 1983-12-06 The Dow Chemical Company 3-(1H-Tetrazol-5-yl)-4(3H)-quinazolinones
US4474953A (en) * 1982-09-09 1984-10-02 Riker Laboratories, Inc. Process and intermediates for the preparation of 3(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-ones
US4476130A (en) * 1982-09-09 1984-10-09 Riker Laboratories, Inc. 3-(1H-Tetrazol-5-yl)-4H-pyrimido[2,1-b]benzoxazol-4-one compounds exhibiting anti-allergic activity
US4507477A (en) * 1982-09-09 1985-03-26 Riker Laboratories, Inc. Process for tetrazolyl-pyrimidinone derivatives
US4457932A (en) * 1983-07-22 1984-07-03 Bristol-Myers Company Anti-ulcer agents
AU588917B2 (en) * 1985-09-25 1989-09-28 Shionogi & Co., Ltd. 9-(substituted thio)-4h-pryido(1,2-a) pyrimidin-4-one derivatives
JPS63183581A (ja) * 1985-10-03 1988-07-28 Tokyo Tanabe Co Ltd ピリド〔１，２−ａ〕ピリミジン誘導体、その製造法及びそれを有効成分とするアレルギ−疾患治療薬
JPS62242682A (ja) * 1986-04-16 1987-10-23 Tokyo Tanabe Co Ltd 新規なピリド［１，２―ａ］ピリミジン誘導体及びその製造法
JP2504788B2 (ja) * 1987-11-10 1996-06-05 東京田辺製薬株式会社 ９−メチル−３−（１Ｈ−テトラゾ―ル−５−イル）−４Ｈ−ピリド［１，２−ａ］ピリミジン−４−オンカリウム塩の水性製剤
WO1989006130A1 (fr) * 1987-12-25 1989-07-13 Santen Pharmaceutical Co., Ltd. Collyre antiallergique
CA2010336C (fr) * 1989-02-27 1996-11-19 Atsunori Sano Procede de production d'un derive de pyrido [1,2-a] pyrimidine
HU209793B (en) * 1990-09-25 1994-11-28 Chinoin Gyogyszer Es Vegyeszet Process for the production of pyrido[1,2-a]pyrimidine-derivatives and pharmaceutical compositions containing the same
WO1994003172A1 (fr) 1992-07-30 1994-02-17 Tokyo Tanabe Company Limited Remede destine aux troubles inflammatoires de l'intestin
US5527802A (en) * 1992-10-01 1996-06-18 Bristol-Myers Squibb Company New uses of 3-tetrazolo -5,6,7,8- substituted-pyrido (1,2-a) pyrimidin-4-ones
JPH0892093A (ja) * 1994-11-10 1996-04-09 Tokyo Tanabe Co Ltd ９−メチル−３−（１Ｈ−テトラゾール−５−イル）−４Ｈ−ピリド［１，２−ａ］ピリミジン−４−オンの水性製剤
WO2002072580A1 (fr) * 2001-02-26 2002-09-19 Mitsubishi Pharma Corporation Preventifs et/ou remedes contres des maladies renales et l'insuffisance renale
ITMI20011764A1 (it) * 2001-08-10 2003-02-10 Dinamite Dipharma Spa Metodo per l'ottenimento del pemirolast ad elevata purezza
GB0316546D0 (en) * 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds
PT2120919E (pt) * 2006-12-18 2012-11-12 Cardoz Ab Nova combinação para utilização no tratamento de perturbações inflamatórias
CA2673214A1 (fr) * 2006-12-20 2008-06-26 Cardoz Ab Nouvelle combinaison destinee a etre utilisee dans le traitement de troubles inflammatoires
WO2009007673A2 (fr) * 2007-07-11 2009-01-15 Cardoz Ab Nouvelle combinaison pour une utilisation dans le traitement de troubles inflammatoires
WO2009007675A2 (fr) * 2007-07-11 2009-01-15 Cardoz Ab Nouvelle association pour une utilisation dans le traitement de troubles inflammatoires
WO2009007679A2 (fr) * 2007-07-11 2009-01-15 Cardoz Ab Nouvelle association pour une utilisation dans le traitement de troubles inflammatoires
CA2720547A1 (fr) * 2008-04-07 2009-10-15 Cardoz Ab Nouvelle combinaison pour une utilisation dans le traitement de troubles inflammatoires
JP5722317B2 (ja) * 2009-06-16 2015-05-20 カルドズ・アーベー ペミロラストの新しい結晶形
USD661900S1 (en) 2010-02-22 2012-06-19 Bajer Design & Marketing, Inc. Collapsible structure
TR201813877T4 (tr) 2012-02-10 2018-11-21 Hoffmann La Roche Spi̇nal müsküler atrofi̇ni̇n tedavi̇ edi̇lmesi̇ne yöneli̇k bi̇leşi̇kler.
US9371336B2 (en) 2012-03-01 2016-06-21 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
KR102109992B1 (ko) 2012-03-23 2020-05-13 피티씨 테라퓨틱스, 인크. 척수성 근위축증을 치료하기 위한 화합물
WO2015105657A1 (fr) 2013-12-19 2015-07-16 Ptc Therapeutics, Inc. Procédés pour moduler la quantité de transcrits d'arn
WO2016063085A1 (fr) 2014-10-23 2016-04-28 Rspr Pharma Ab Utilisation de pemirolast dans le traitement de l'asthme aigu
WO2016102941A1 (fr) 2014-12-22 2016-06-30 Rspr Pharma Ab Nouvelle association pémirolast et montélukast
WO2016184832A1 (fr) * 2015-05-20 2016-11-24 F. Hoffmann-La Roche Ag Composés pour le traitement d'une amyotrophie spinale
WO2016196386A1 (fr) 2015-05-30 2016-12-08 Ptc Therapeutics, Inc. Procédés de modulation de l'épissage de l'arn
GB201518831D0 (en) 2015-10-23 2015-12-09 Rspr Pharma Ab New use
LT3386511T (lt) 2015-12-10 2021-08-25 Ptc Therapeutics, Inc. Hantingtono ligos gydymo būdai
GB201601138D0 (en) * 2016-01-21 2016-03-09 Rspr Pharma Ab New use
EA201991309A1 (ru) 2016-11-28 2019-11-29 Способы модуляции сплайсинга рнк
EP3634953B1 (fr) 2017-06-05 2024-01-03 PTC Therapeutics, Inc. Composés permettant de traiter la maladie de huntington
KR20200017476A (ko) 2017-06-14 2020-02-18 피티씨 테라퓨틱스, 인크. Rna 스플라이싱의 변경 방법
EP3645121A4 (fr) 2017-06-28 2021-03-17 PTC Therapeutics, Inc. Méthodes de traitement de la maladie de huntington
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
US20210009590A1 (en) 2018-03-27 2021-01-14 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
EP3814357B1 (fr) 2018-06-27 2024-05-01 PTC Therapeutics, Inc. Composés hétérocycliques et hétéroaryles pour le traitement de la maladie de huntington
EP3814360A1 (fr) 2018-06-27 2021-05-05 PTC Therapeutics, Inc. Composés hétéroaryles pour le traitement de la maladie de huntington

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4012387A (en) * 1975-09-18 1977-03-15 Warner-Lambert Company Benzo-[g]pyrido[2,1-b]quinazolinones

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3072485A (en) * 1960-08-24 1963-01-08 Eastman Kodak Co Optically sensitized azido polymers for photomechanical resist compositions
CH538494A (de) * 1966-11-02 1973-06-30 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung neuer Homopyrimidazol-Derivate
US3960847A (en) * 1972-04-17 1976-06-01 E. R. Squibb & Sons, Inc. 9-Substituted-4-oxopyrido(1,2-α)pyrimidine-3-carboxylic acids and derivatives thereof
US3929787A (en) * 1974-04-22 1975-12-30 Squibb & Sons Inc 6,7,8,9-Tetrahydro-pyrido(1,2-a)pyrimidin-4-ones
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
US4017625A (en) * 1975-08-01 1977-04-12 Pfizer Inc. Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4012387A (en) * 1975-09-18 1977-03-15 Warner-Lambert Company Benzo-[g]pyrido[2,1-b]quinazolinones

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2423490A1 (fr) * 1978-04-03 1979-11-16 Bristol Myers Co Nouveaux 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-n-(1h-tetrazol-5-yl) carboxamides eventuellement substitues, leur procede de production et medicament les contenant
FR2424924A1 (fr) * 1978-05-05 1979-11-30 Bristol Myers Co Nouvelles azolopyrimidinones, leur procede de production et medicament les contenant

Also Published As

Publication number Publication date
YU42163B (en) 1988-06-30
AU3631978A (en) 1979-11-29
CH642656A5 (de) 1984-04-30
NO150361B (no) 1984-06-25
NL7805534A (nl) 1978-11-28
HK25884A (en) 1984-03-30
IT1105040B (it) 1985-10-28
BE867295A (fr) 1978-11-20
YU44212B (en) 1990-04-30
FI64594C (fi) 1983-12-12
NO781786L (no) 1978-11-28
JPS6050197B2 (ja) 1985-11-07
DK160279B (da) 1991-02-18
DK160279C (da) 1991-07-22
FI781614A (fi) 1978-11-26
US4122274A (en) 1978-10-24
IE46849B1 (en) 1983-10-05
YU123678A (en) 1983-02-28
ATA373278A (de) 1981-05-15
SE7805954L (sv) 1978-11-26
DK228878A (da) 1978-11-26
NL190702C (nl) 1994-07-01
DE2822544A1 (de) 1978-12-07
CY1218A (en) 1984-04-06
IE781036L (en) 1978-11-25
FI64594B (fi) 1983-08-31
SE437830B (sv) 1985-03-18
YU233082A (en) 1988-08-31
KE3357A (en) 1984-02-03
FR2401159B1 (fr) 1983-05-20
CA1098520A (fr) 1981-03-31
LU79694A1 (fr) 1979-02-02
AT365187B (de) 1981-12-28
DE2822544C2 (fr) 1988-10-27
GB1596476A (en) 1981-08-26
JPS5436294A (en) 1979-03-16
ZA782816B (en) 1979-05-30
MY8500305A (en) 1985-12-31
SG73383G (en) 1984-08-03
NL190702B (nl) 1994-02-01
NO150361C (no) 1984-10-03
AU521211B2 (en) 1982-03-25
GR71887B (fr) 1983-08-04
IT7849523A0 (it) 1978-05-24

Similar Documents

Publication Publication Date Title
FR2401159A1 (fr) Derives de 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidine-4-one, leur procede de preparation et leur activite therapeutique
FR2389640A1 (fr)
FR2392016A1 (fr) Derives de mevalonolactone, leur procede de preparation et leur application therapeutique
HUP9600448A2 (hu) Naftilvegyületek, e vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra, intermedierjeik és alkalmazásuk
FR2435248A1 (fr) Derives de 4-anilinoquinazoline, leur procede de preparation et leur application en therapeutique
FR2385722A1 (fr) Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique
ATE255091T1 (de) 1-acetyl-5-bromo-4,6-dimethylindolin
HUP9801230A2 (hu) Benzopiránszármazékok, valamint felhasználásuk ösztrogénérzékenység okozta betegségek kezelésére alkalmas gyógyszerkészítmények előállítására
FR2421899A1 (fr) Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
FR2453155A1 (fr) Derives de cyanoguanidine, leur procede de preparation et leurs applications en therapeutique
FR2405246A1 (fr) Nouveaux derives de pyrrole, leur procede de preparation et leurs applications en therapeutique
TNSN87012A1 (fr) Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
FR2453151A1 (fr) Derives de la vitamine d3, leur procede de preparation et leur application en therapeutique
FR2387988A1 (fr) Esters de cefuroxime, leur preparation et leur application therapeutique
NO881835D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive bicykliske forbindelser.
FR2358406A1 (fr) Derives d'acides 5-aroyl-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxyliques, leur obtention et leur application a titre de medicament
FR2417502A1 (fr) Nouvelles 2-phenylimino-imidazolidines substituees, leurs sels d'addition avec des acides, medicaments les renfermant et procedes pour leur preparation
FR2432520A1 (fr) Nouvelles imidazoquinoxalines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
FR2395272A1 (fr) Nouveaux medicaments derives de l'acide amidinopenicillanique
FR2387230A1 (fr) Nouvelles pyrroloquinoxalines et leurs sels, procede de preparation et application a titre de medicaments
BE883686A (fr) Derives de la paromomycine, procede pour les preparer et leur usage comme medicament
FR2416886A1 (fr) Nouveaux derives de la 3-phenyl-tetrahydropyridine et leurs sels, procedes de preparation et application a titre de medicaments
FR2388789A1 (fr) Derives d'acide benzoique, leur procede de preparation et leur application therapeutique
IL92233A0 (en) 1,2,3,4-tetrahydro-1,9-acridinediamines,a process for their preparation and their use as pharmaceutical compositions
FR2355831A1 (fr) Derives de benzazocine, leur procede de preparation et leur application therapeutique