FR2423490A1 - Nouveaux 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-n-(1h-tetrazol-5-yl) carboxamides eventuellement substitues, leur procede de production et medicament les contenant - Google Patents

Nouveaux 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-n-(1h-tetrazol-5-yl) carboxamides eventuellement substitues, leur procede de production et medicament les contenant

Info

Publication number
FR2423490A1
FR2423490A1 FR7907971A FR7907971A FR2423490A1 FR 2423490 A1 FR2423490 A1 FR 2423490A1 FR 7907971 A FR7907971 A FR 7907971A FR 7907971 A FR7907971 A FR 7907971A FR 2423490 A1 FR2423490 A1 FR 2423490A1
Authority
FR
France
Prior art keywords
tetrazol
pyrido
oxo
new
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7907971A
Other languages
English (en)
Other versions
FR2423490B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2423490A1 publication Critical patent/FR2423490A1/fr
Application granted granted Critical
Publication of FR2423490B1 publication Critical patent/FR2423490B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

L'invention a trait du domaine de la chimie médicale. Elle concerne une nouvelle série de 4-oxo-4H-pyrido-Ø1,2-aõpyrimidine-3-N-(1H-tétrazol-5-yl)carboxamides eventuellement substitués, ainsi qu'un procédé permettant de les obtenir. Les nouveaux composés de l'invention sont des inhibiteurs des réactions allergiques. Ils déploient une activité anti-allergique lorsqu'on les administre tant par voie orale que par voie parentérale.
FR7907971A 1978-04-03 1979-03-29 Nouveaux 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-n-(1h-tetrazol-5-yl) carboxamides eventuellement substitues, leur procede de production et medicament les contenant Granted FR2423490A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/892,714 US4192944A (en) 1978-04-03 1978-04-03 Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents

Publications (2)

Publication Number Publication Date
FR2423490A1 true FR2423490A1 (fr) 1979-11-16
FR2423490B1 FR2423490B1 (fr) 1982-03-19

Family

ID=25400392

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7907971A Granted FR2423490A1 (fr) 1978-04-03 1979-03-29 Nouveaux 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-n-(1h-tetrazol-5-yl) carboxamides eventuellement substitues, leur procede de production et medicament les contenant

Country Status (15)

Country Link
US (1) US4192944A (fr)
JP (1) JPS54141797A (fr)
BE (1) BE875246A (fr)
CA (1) CA1117112A (fr)
CH (1) CH643256A5 (fr)
DE (1) DE2913295A1 (fr)
DK (1) DK153485C (fr)
FR (1) FR2423490A1 (fr)
GB (1) GB2019836B (fr)
IE (1) IE48278B1 (fr)
IT (1) IT1116537B (fr)
LU (1) LU81107A1 (fr)
NL (1) NL7902444A (fr)
SE (1) SE440652B (fr)
ZA (1) ZA791525B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495189A (en) * 1975-11-27 1985-01-22 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. Condensed pyrimidines
HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom
IE51802B1 (en) * 1979-12-03 1987-04-01 Fujisawa Pharmaceutical Co Quinazoline derivatives,processes for their preparation and pharmaceutical compositions containing them
CA1157858A (fr) 1979-12-03 1983-11-29 Ikuo Ueda Derives de quinazoline
JPS63183581A (ja) * 1985-10-03 1988-07-28 Tokyo Tanabe Co Ltd ピリド〔１，２−ａ〕ピリミジン誘導体、その製造法及びそれを有効成分とするアレルギ−疾患治療薬
HU201551B (en) * 1988-02-03 1990-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-carboxylic acid amide derivatives and pharmaceutical compositions comprising same
US6295995B1 (en) * 2000-04-07 2001-10-02 Irene D. Ewaka Permanently covered rigid or semi-rigid mounting piece for an article of fashion

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319363A1 (fr) * 1975-08-01 1977-02-25 Pfizer N-(5-tetrazolyl)-1-oxo-1h-6-alcoxypyrimido (1,2-a) quinoleine-2-carboxamides anti-allergiques et intermediaires appropries
FR2401159A1 (fr) * 1977-05-25 1979-03-23 Bristol Myers Co Derives de 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidine-4-one, leur procede de preparation et leur activite therapeutique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3072485A (en) * 1960-08-24 1963-01-08 Eastman Kodak Co Optically sensitized azido polymers for photomechanical resist compositions
AT302311B (de) * 1966-11-02 1972-09-15 Chinoin Gyogyszer Es Vegyeszet Verfahren zur herstellung von homopyrimidazol-derivaten und deren saeureadditionssalzen und quaternaeren ammoniumsalzen
US3960847A (en) * 1972-04-17 1976-06-01 E. R. Squibb & Sons, Inc. 9-Substituted-4-oxopyrido(1,2-α)pyrimidine-3-carboxylic acids and derivatives thereof
US3929787A (en) * 1974-04-22 1975-12-30 Squibb & Sons Inc 6,7,8,9-Tetrahydro-pyrido(1,2-a)pyrimidin-4-ones
US4017625A (en) * 1975-08-01 1977-04-12 Pfizer Inc. Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor
HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319363A1 (fr) * 1975-08-01 1977-02-25 Pfizer N-(5-tetrazolyl)-1-oxo-1h-6-alcoxypyrimido (1,2-a) quinoleine-2-carboxamides anti-allergiques et intermediaires appropries
FR2401159A1 (fr) * 1977-05-25 1979-03-23 Bristol Myers Co Derives de 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidine-4-one, leur procede de preparation et leur activite therapeutique

Also Published As

Publication number Publication date
IT7948569A0 (it) 1979-04-02
SE440652B (sv) 1985-08-12
JPS6256874B2 (fr) 1987-11-27
NL7902444A (nl) 1979-10-05
IE48278B1 (en) 1984-11-28
DE2913295C2 (fr) 1988-09-22
US4192944A (en) 1980-03-11
FR2423490B1 (fr) 1982-03-19
JPS54141797A (en) 1979-11-05
BE875246A (fr) 1979-10-01
GB2019836B (en) 1982-06-03
IE790950L (en) 1979-10-03
CA1117112A (fr) 1982-01-26
SE7902915L (sv) 1979-10-04
DK153485B (da) 1988-07-18
LU81107A1 (fr) 1979-11-07
IT1116537B (it) 1986-02-10
CH643256A5 (de) 1984-05-30
DK153485C (da) 1988-11-21
DK130079A (da) 1979-10-04
ZA791525B (en) 1980-11-26
DE2913295A1 (de) 1979-10-18
GB2019836A (en) 1979-11-07

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