FR2430939A1 - Nouveaux derives d'acides (dl)-16-(phenoxy ou phenoxy substitue)-9-ceto- prostatrienoiques, leur procede de production et medicament les contenant - Google Patents
Nouveaux derives d'acides (dl)-16-(phenoxy ou phenoxy substitue)-9-ceto- prostatrienoiques, leur procede de production et medicament les contenantInfo
- Publication number
- FR2430939A1 FR2430939A1 FR7917796A FR7917796A FR2430939A1 FR 2430939 A1 FR2430939 A1 FR 2430939A1 FR 7917796 A FR7917796 A FR 7917796A FR 7917796 A FR7917796 A FR 7917796A FR 2430939 A1 FR2430939 A1 FR 2430939A1
- Authority
- FR
- France
- Prior art keywords
- phenoxy
- prostatrienoiques
- substitue
- ceto
- production process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 title abstract 3
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical class O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 2
- 150000003180 prostaglandins Chemical class 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
L'invention a trait au domaine de la chimie médicale. Elle concerne de nouveaux dérivés 16-phénoxy et 16(phénoxy substitué en ortho, méta ou para) d'acide (dl)-9-céto-11 alpha , 15 alpha -dihydroxy-17, 18, 19, 20-tétranorprosta-4, 5, 13-trans-triénoïque, leurs esters alkyliques inférieurs et leurs sels non toxiques, acceptables du point de vue pharmaceutique, ainsi que des procédés de production de ces composés. Les composés de l'invention ont des activités semblables à celles des prostaglandines et sont donc intéressants à utiliser dans le traitement de mammifères dont l'état nécessite l'administration de prostaglandines. Ils sont particulièrement utiles comme inhibiteurs de la sécrétion gastrique d'acide et comme agents permettant de combattre les crises d'asthme, en raison de leur activité broncho-dilatatrice.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/922,957 US4178457A (en) | 1978-07-10 | 1978-07-10 | (dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives and processes for the production thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2430939A1 true FR2430939A1 (fr) | 1980-02-08 |
FR2430939B1 FR2430939B1 (fr) | 1981-08-14 |
Family
ID=25447871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7917796A Granted FR2430939A1 (fr) | 1978-07-10 | 1979-07-09 | Nouveaux derives d'acides (dl)-16-(phenoxy ou phenoxy substitue)-9-ceto- prostatrienoiques, leur procede de production et medicament les contenant |
Country Status (26)
Country | Link |
---|---|
US (1) | US4178457A (fr) |
EP (1) | EP0008003B1 (fr) |
JP (1) | JPS5513282A (fr) |
KR (1) | KR890002773B1 (fr) |
AT (1) | ATE2427T1 (fr) |
AU (1) | AU527516B2 (fr) |
CA (1) | CA1149802A (fr) |
CS (1) | CS209927B2 (fr) |
DD (1) | DD146179A5 (fr) |
DE (2) | DE2964709D1 (fr) |
DK (1) | DK157753C (fr) |
ES (1) | ES482330A1 (fr) |
FI (1) | FI69061C (fr) |
FR (1) | FR2430939A1 (fr) |
GB (1) | GB2025413B (fr) |
HK (1) | HK41384A (fr) |
HU (1) | HU184185B (fr) |
IT (1) | IT1121462B (fr) |
MY (1) | MY8500576A (fr) |
NO (4) | NO150836C (fr) |
NZ (1) | NZ190924A (fr) |
PL (4) | PL121778B1 (fr) |
SG (1) | SG82483G (fr) |
SU (1) | SU1031407A3 (fr) |
YU (3) | YU41870B (fr) |
ZA (1) | ZA793293B (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4328245A (en) * | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4358603A (en) * | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
US4409239A (en) * | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
US4600785A (en) * | 1983-12-22 | 1986-07-15 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
US4804787A (en) * | 1983-12-22 | 1989-02-14 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
US4912235A (en) * | 1983-12-22 | 1990-03-27 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy- and 16-substituted phenoxy-prostatrienoic acid derivatives and their stereoisomers |
DE3414509A1 (de) * | 1984-04-13 | 1985-10-24 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 9-halogen-prostaglandine |
NZ212914A (en) * | 1984-07-31 | 1988-08-30 | Syntex Inc | Tetranorprostaglandin derivatives and pharmaceutical compositions |
US5057621A (en) * | 1984-07-31 | 1991-10-15 | Syntex (U.S.A.) Inc. | 11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
US4792617A (en) * | 1984-07-31 | 1988-12-20 | Syntex (U.S.A.) Inc. | 11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienioc acid derivatives |
US4618696A (en) * | 1984-07-31 | 1986-10-21 | Syntex (U.S.A.) Inc. | 9-oxo-15α-hydroxy-16-phenoxy and 16-substituted phenoxy 17,18,19,20-tetranorprosta-4,5,13,(E)-trienoates |
US4778904A (en) * | 1985-09-13 | 1988-10-18 | Syntex (U.S.A.) Inc. | Intermediates for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives |
EP0248999A3 (fr) * | 1986-04-11 | 1988-03-16 | Syntex (U.S.A.) Inc. | Prostaglandines du type enprostil pour la régulation du métabolisme des lipides et hydrates de carbone |
US4755531A (en) * | 1986-08-11 | 1988-07-05 | Syntex (U.S.A.) Inc. | Thiol esters of 4,5-allenyl prostaglandins and use thereof as antigastric secretion agents |
GB8625321D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Chemical compounds |
US4689419A (en) * | 1986-11-14 | 1987-08-25 | G. D. Searle & Co. | Novel intermediate compounds in a process for producing 16-phenoxy- and 16-substituted phenoxy-9-keto-prostatrienoic acid derivatives |
US6103765A (en) | 1997-07-09 | 2000-08-15 | Androsolutions, Inc. | Methods for treating male erectile dysfunction |
AU742787B2 (en) | 1997-07-09 | 2002-01-10 | Androsolutions, Inc. | Improved methods and compositions for treating male erectile dysfunction |
US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
US20020037914A1 (en) | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
US8966971B2 (en) * | 2008-07-28 | 2015-03-03 | Ford Global Technologies, Llc | Vehicle engine with fluid measuring system |
US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
JP2012507552A (ja) * | 2008-10-29 | 2012-03-29 | アエリエ・ファーマシューティカルズ・インコーポレーテッド | プロスタグラジンのアミノ酸塩 |
US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3985791A (en) * | 1975-06-23 | 1976-10-12 | Syntex (U.S.A.) Inc. | 16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
-
1978
- 1978-07-10 US US05/922,957 patent/US4178457A/en not_active Expired - Lifetime
-
1979
- 1979-07-03 ZA ZA793293A patent/ZA793293B/xx unknown
- 1979-07-04 AU AU48641/79A patent/AU527516B2/en not_active Ceased
- 1979-07-05 NZ NZ190924A patent/NZ190924A/xx unknown
- 1979-07-05 CS CS794752A patent/CS209927B2/cs unknown
- 1979-07-06 FI FI792149A patent/FI69061C/fi not_active IP Right Cessation
- 1979-07-06 JP JP8511679A patent/JPS5513282A/ja active Granted
- 1979-07-06 CA CA000331348A patent/CA1149802A/fr not_active Expired
- 1979-07-09 DK DK288879A patent/DK157753C/da not_active IP Right Cessation
- 1979-07-09 ES ES482330A patent/ES482330A1/es not_active Expired
- 1979-07-09 FR FR7917796A patent/FR2430939A1/fr active Granted
- 1979-07-09 EP EP79102349A patent/EP0008003B1/fr not_active Expired
- 1979-07-09 NO NO792283A patent/NO150836C/no unknown
- 1979-07-09 SU SU792786000A patent/SU1031407A3/ru active
- 1979-07-09 AT AT79102349T patent/ATE2427T1/de not_active IP Right Cessation
- 1979-07-09 DE DE7979102349T patent/DE2964709D1/de not_active Expired
- 1979-07-09 IT IT68428/79A patent/IT1121462B/it active
- 1979-07-09 DD DD214202A patent/DD146179A5/de unknown
- 1979-07-09 GB GB7923914A patent/GB2025413B/en not_active Expired
- 1979-07-09 DE DE19792927715 patent/DE2927715A1/de active Granted
- 1979-07-10 PL PL1979217001A patent/PL121778B1/pl unknown
- 1979-07-10 HU HU79SI1706A patent/HU184185B/hu unknown
- 1979-07-10 PL PL1979224557A patent/PL120632B1/pl unknown
- 1979-07-10 PL PL1979224555A patent/PL120604B1/pl unknown
- 1979-07-10 PL PL1979224556A patent/PL120633B1/pl unknown
- 1979-07-10 YU YU1685/79A patent/YU41870B/xx unknown
-
1982
- 1982-01-29 KR KR8200378A patent/KR890002773B1/ko active
-
1983
- 1983-12-27 SG SG824/83A patent/SG82483G/en unknown
-
1984
- 1984-01-24 NO NO840256A patent/NO152296C/no unknown
- 1984-01-24 NO NO840257A patent/NO152211C/no unknown
- 1984-01-24 NO NO840258A patent/NO152212C/no unknown
- 1984-05-10 HK HK413/84A patent/HK41384A/xx unknown
-
1985
- 1985-12-30 MY MY576/85A patent/MY8500576A/xx unknown
-
1986
- 1986-05-08 YU YU735/86A patent/YU44553B/xx unknown
- 1986-05-08 YU YU736/86A patent/YU44554B/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3985791A (en) * | 1975-06-23 | 1976-10-12 | Syntex (U.S.A.) Inc. | 16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |