ES482330A1 - Un procedimiento para producir derivados de acido (dl)-16- fenoxi, y 16-fenoxi-sustituido-9-ceto-prostatrienoico. - Google Patents

Un procedimiento para producir derivados de acido (dl)-16- fenoxi, y 16-fenoxi-sustituido-9-ceto-prostatrienoico.

Info

Publication number
ES482330A1
ES482330A1 ES482330A ES482330A ES482330A1 ES 482330 A1 ES482330 A1 ES 482330A1 ES 482330 A ES482330 A ES 482330A ES 482330 A ES482330 A ES 482330A ES 482330 A1 ES482330 A1 ES 482330A1
Authority
ES
Spain
Prior art keywords
phenoxy
keto
processes
production
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES482330A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES482330A1 publication Critical patent/ES482330A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Abstract

Un procedimiento para producir derivados de ácido (dl)-16-fenoxi-substituido-9-ceto-pros- tatrienoico, de la fórmula general: **(fórmula-01)** en donde R es hidrógeno, un grupo de alquilo inferior con 1 a 4 átomos de carbono, o las sales atóxicas y aceptables en farmacia de los compuestos en donde R es hidrógeno; y X es hidrógeno, o-, m-, o p-halo (fluor, cloro o bromo), o-, m- o p-metilo o o-, m- o p-metoxilo caracterizado porque comprende: a) separar los grupos protectores en las posiciones 11alfa y 15alfa con lo que se obtiene el compuesto de la fórmula: **(fórmula-02)** en donde R y X tienen el significado expuesto antes; o b) hidrolizar un éster para obtener el ácido carboxílico libre correspondiente o sal respectiva; o c) convertir, opcionalmente, el ácido carboxílico en un éster o una sal etóxica farmacéutica; o d) acidificar una sal del ácido carboxílico para obtener un compuesto de la fórmula (A) en donde R es hidrógeno.
ES482330A 1978-07-10 1979-07-09 Un procedimiento para producir derivados de acido (dl)-16- fenoxi, y 16-fenoxi-sustituido-9-ceto-prostatrienoico. Expired ES482330A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/922,957 US4178457A (en) 1978-07-10 1978-07-10 (dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives and processes for the production thereof

Publications (1)

Publication Number Publication Date
ES482330A1 true ES482330A1 (es) 1980-08-16

Family

ID=25447871

Family Applications (1)

Application Number Title Priority Date Filing Date
ES482330A Expired ES482330A1 (es) 1978-07-10 1979-07-09 Un procedimiento para producir derivados de acido (dl)-16- fenoxi, y 16-fenoxi-sustituido-9-ceto-prostatrienoico.

Country Status (26)

Country Link
US (1) US4178457A (es)
EP (1) EP0008003B1 (es)
JP (1) JPS5513282A (es)
KR (1) KR890002773B1 (es)
AT (1) ATE2427T1 (es)
AU (1) AU527516B2 (es)
CA (1) CA1149802A (es)
CS (1) CS209927B2 (es)
DD (1) DD146179A5 (es)
DE (2) DE2964709D1 (es)
DK (1) DK157753C (es)
ES (1) ES482330A1 (es)
FI (1) FI69061C (es)
FR (1) FR2430939A1 (es)
GB (1) GB2025413B (es)
HK (1) HK41384A (es)
HU (1) HU184185B (es)
IT (1) IT1121462B (es)
MY (1) MY8500576A (es)
NO (4) NO150836C (es)
NZ (1) NZ190924A (es)
PL (4) PL120632B1 (es)
SG (1) SG82483G (es)
SU (1) SU1031407A3 (es)
YU (3) YU41870B (es)
ZA (1) ZA793293B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328245A (en) * 1981-02-13 1982-05-04 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4358603A (en) * 1981-04-16 1982-11-09 Syntex (U.S.A.) Inc. Acetal stabilized prostaglandin compositions
US4409239A (en) * 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
US4600785A (en) * 1983-12-22 1986-07-15 Syntex (U.S.A.) Inc. Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
US4912235A (en) * 1983-12-22 1990-03-27 Syntex (U.S.A.) Inc. Processes and intermediates for making 16-phenoxy- and 16-substituted phenoxy-prostatrienoic acid derivatives and their stereoisomers
US4804787A (en) * 1983-12-22 1989-02-14 Syntex (U.S.A.) Inc. Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
DE3414509A1 (de) * 1984-04-13 1985-10-24 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 9-halogen-prostaglandine
US4792617A (en) * 1984-07-31 1988-12-20 Syntex (U.S.A.) Inc. 11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienioc acid derivatives
US4618696A (en) * 1984-07-31 1986-10-21 Syntex (U.S.A.) Inc. 9-oxo-15α-hydroxy-16-phenoxy and 16-substituted phenoxy 17,18,19,20-tetranorprosta-4,5,13,(E)-trienoates
US5057621A (en) * 1984-07-31 1991-10-15 Syntex (U.S.A.) Inc. 11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
DE3574968D1 (de) * 1984-07-31 1990-02-01 Syntex Inc 11-substituierte-16-phenoxy und 16-phenoxysubstituierte prostatriensaeurederivate.
US4778904A (en) * 1985-09-13 1988-10-18 Syntex (U.S.A.) Inc. Intermediates for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
DK185987A (da) * 1986-04-11 1987-10-12 Syntex Inc Anvendelse af prostaglandiner
US4755531A (en) * 1986-08-11 1988-07-05 Syntex (U.S.A.) Inc. Thiol esters of 4,5-allenyl prostaglandins and use thereof as antigastric secretion agents
GB8625321D0 (en) * 1986-10-22 1986-11-26 Glaxo Group Ltd Chemical compounds
US4689419A (en) * 1986-11-14 1987-08-25 G. D. Searle & Co. Novel intermediate compounds in a process for producing 16-phenoxy- and 16-substituted phenoxy-9-keto-prostatrienoic acid derivatives
KR20010021625A (ko) 1997-07-09 2001-03-15 추후보정 개선된 남성발기 기능장애 치료방법 및 그 조성물
US6103765A (en) 1997-07-09 2000-08-15 Androsolutions, Inc. Methods for treating male erectile dysfunction
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US8966971B2 (en) * 2008-07-28 2015-03-03 Ford Global Technologies, Llc Vehicle engine with fluid measuring system
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
AU2009340420A1 (en) * 2008-10-29 2010-08-26 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES449162A1 (es) * 1975-06-23 1977-12-16 Syntex Inc Un procedimiento para la preparacion de un compuesto racemi-co u 8r-antimerico.

Also Published As

Publication number Publication date
PL120632B1 (en) 1982-03-31
NO150836B (no) 1984-09-17
AU527516B2 (en) 1983-03-10
EP0008003B1 (en) 1983-02-09
NZ190924A (en) 1980-11-28
PL217001A1 (es) 1980-03-24
NO840258L (no) 1980-01-11
GB2025413A (en) 1980-01-23
NO152212C (no) 1985-08-21
HK41384A (en) 1984-05-18
FR2430939A1 (fr) 1980-02-08
PL120633B1 (en) 1982-03-31
DE2927715C2 (es) 1987-08-27
JPS6210227B2 (es) 1987-03-05
DK157753C (da) 1990-07-09
NO840257L (no) 1980-01-11
PL120604B1 (en) 1982-03-31
NO792283L (no) 1980-01-11
NO152296B (no) 1985-05-28
YU44553B (en) 1990-08-31
YU41870B (en) 1988-02-29
NO840256L (no) 1980-01-11
ATE2427T1 (de) 1983-03-15
EP0008003A1 (en) 1980-02-20
CS209927B2 (en) 1981-12-31
FR2430939B1 (es) 1981-08-14
NO152296C (no) 1985-09-04
NO152212B (no) 1985-05-13
IT1121462B (it) 1986-04-02
FI69061C (fi) 1985-12-10
GB2025413B (en) 1982-07-28
SU1031407A3 (ru) 1983-07-23
YU73586A (en) 1986-12-31
ZA793293B (en) 1981-02-25
DE2964709D1 (en) 1983-03-17
DD146179A5 (de) 1981-01-28
DK157753B (da) 1990-02-12
AU4864179A (en) 1980-02-07
FI792149A (fi) 1980-01-11
YU73686A (en) 1986-12-31
SG82483G (en) 1984-08-03
JPS5513282A (en) 1980-01-30
YU44554B (en) 1990-08-31
DE2927715A1 (de) 1980-01-24
FI69061B (fi) 1985-08-30
NO150836C (no) 1985-01-09
CA1149802A (en) 1983-07-12
MY8500576A (en) 1985-12-31
DK288879A (da) 1980-01-11
NO152211C (no) 1985-08-21
YU168579A (en) 1983-02-28
IT7968428A0 (it) 1979-07-09
PL121778B1 (en) 1982-05-31
KR890002773B1 (ko) 1989-07-28
US4178457A (en) 1979-12-11
HU184185B (en) 1984-07-30
NO152211B (no) 1985-05-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203