ES8307098A1 - Un procedimiento para la preparacion de un nuevo antitrombosico a base de oligosacaridos y polisacaridos. - Google Patents
Un procedimiento para la preparacion de un nuevo antitrombosico a base de oligosacaridos y polisacaridos.Info
- Publication number
- ES8307098A1 ES8307098A1 ES512464A ES512464A ES8307098A1 ES 8307098 A1 ES8307098 A1 ES 8307098A1 ES 512464 A ES512464 A ES 512464A ES 512464 A ES512464 A ES 512464A ES 8307098 A1 ES8307098 A1 ES 8307098A1
- Authority
- ES
- Spain
- Prior art keywords
- thromboticum
- preparation
- pharmaceutical compositions
- polysacharides
- new anti
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UN NUEVO ANTITROMBOSICO A BASE DE OLIGOSACARIDOS Y POLISACARIDOS. SE SOMETEN A AUTOLISIS O A LA ACCION DE ENZIMAS PROTEOLITICOS UNOS TEJIDOS DE MAMIFERO COMO PULMONES, PANCREAS, HIGADO, INTESTINOS Y MUCOSA INTESTINAL; FILTRAR LA MEZCLA RESULTANTE; AISLAR EL PRODUCTO DEL FILTRADO POR PRECIPITACION CON DISOLVENTES ORGANICOS O POR COMBINACION CON UNA BASE AMONICA ALIFATICA CUATERNARIA O CON UN CAMBIADOR DE ION BASICO, SEGUIDO DE ELUCION CON SOLUCIONES SALINAS ACUOSAS Y, SI ES NECESARIO, PURIFICAR POSTERIORMENTE EL PRODUCTO POR PRECIPITACION FRACCIONADA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8102514 | 1981-05-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8307098A1 true ES8307098A1 (es) | 1983-07-01 |
ES512464A0 ES512464A0 (es) | 1983-07-01 |
Family
ID=19837549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES512464A Granted ES512464A0 (es) | 1981-05-21 | 1982-05-21 | Un procedimiento para la preparacion de un nuevo antitrombosico a base de oligosacaridos y polisacaridos. |
Country Status (16)
Country | Link |
---|---|
US (1) | US4438108A (es) |
EP (1) | EP0066908B1 (es) |
JP (1) | JPS57197221A (es) |
AT (1) | ATE15142T1 (es) |
AU (1) | AU550317B2 (es) |
CA (1) | CA1186646A (es) |
DE (1) | DE3265781D1 (es) |
DK (1) | DK157061C (es) |
ES (1) | ES512464A0 (es) |
FI (1) | FI75491C (es) |
GR (1) | GR76794B (es) |
HU (1) | HU190687B (es) |
IE (1) | IE53255B1 (es) |
NZ (1) | NZ200688A (es) |
PT (1) | PT74928B (es) |
ZA (1) | ZA823248B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4696816A (en) * | 1985-11-07 | 1987-09-29 | Brown Mark D | Method for treating intervertebral disc displacement with enzymes |
US4745106A (en) * | 1986-08-20 | 1988-05-17 | Griffin Charles C | Heparin derivatives having improved anti-Xa specificity |
US4942156A (en) * | 1986-08-20 | 1990-07-17 | Hepar Industries, Inc. | Low molecular weight heparin derivatives having improved anti-Xa specificity |
DE3639561A1 (de) * | 1986-11-20 | 1988-06-01 | Baumann Hanno | Verfahren zur herstellung von nicht-thrombogenen substraten |
IT1213384B (it) * | 1986-11-24 | 1989-12-20 | Lab Derivati Organici Mediolan | Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare. |
EP0333243A3 (en) * | 1988-03-10 | 1989-09-27 | Akzo N.V. | Sulphated k5 antigen and sulphated k5 antigen fragments |
EP0337327A1 (en) * | 1988-04-09 | 1989-10-18 | Bioiberica, S.A. | Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin |
IT1234826B (it) * | 1989-01-30 | 1992-05-29 | Alfa Wassermann Spa | Derivati eparinici e procedimento per la loro preparazione |
EP0421508B1 (en) * | 1989-10-04 | 1993-12-15 | Akzo Nobel N.V. | Sulphated glycosaminoglycuronan with antithrombotic activity |
USRE38743E1 (en) | 1990-06-26 | 2005-06-14 | Aventis Pharma S.A. | Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events |
FR2663639B1 (fr) * | 1990-06-26 | 1994-03-18 | Rhone Poulenc Sante | Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation. |
US5306711A (en) * | 1992-06-24 | 1994-04-26 | Georgetown University | Organ preservative solution |
FR2723847A1 (fr) * | 1994-08-29 | 1996-03-01 | Debiopharm Sa | Compositions antithrombotiques et non hemorragiques a base d'heparine, procede pour leur preparation et applications therapeutiques. |
DE19646901A1 (de) * | 1996-11-13 | 1998-05-14 | Helmut Prof Dr Heusinger | Verfahren zum Herstellen von Abbauprodukten polymerer Glycosaminoglycane mittels Ultraschall |
IL129877A (en) * | 1996-11-27 | 2004-08-31 | Aventis Pharm Prod Inc | A pharmaceutical preparation containing a component having an Xa antagonist activity and an antifouling agent |
BR0012202A (pt) * | 1999-06-30 | 2002-04-02 | Hamilton Civic Hospitals Res | Composições de heparina de peso molecular médio (mmwh), método de tratamento de uma condição trombótica, método de prevenção da formação de um trombo, método de inibição da formação de trombos, composição farmacêutica, método de tratamento de trombose venosa profunda, método de prevenção de embolia pulmonar, método de preparação e usos de uma composição de mmwh |
AU2001291549A1 (en) * | 2000-09-08 | 2002-03-22 | Hamilton Civic Hospitals Research Development Inc. | Antithrombotic compositions |
US7618652B2 (en) * | 2001-03-23 | 2009-11-17 | Hepmarin As | Glycosaminoglycan anticoagulants derived from fish |
US20040171819A1 (en) | 2002-10-10 | 2004-09-02 | Aventis Pharma S.A. | Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
JP2006096668A (ja) * | 2002-11-08 | 2006-04-13 | Ono Pharmaceut Co Ltd | エラスターゼ阻害剤と血液凝固系および/または線溶系酵素阻害剤との組み合わせからなる医薬 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3451996A (en) * | 1968-02-12 | 1969-06-24 | Thompson Farms Co | Method for the preparation of heparin |
US3766167A (en) * | 1971-03-26 | 1973-10-16 | Research Corp | Orally active anticoagulant |
DE2652272C2 (de) * | 1976-11-12 | 1979-02-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Heparin |
IT1075117B (it) * | 1977-02-14 | 1985-04-22 | Fedeli Gianfranco | Complesso polisaccaridico arterioso,processo per la sua preparazione e suo impiego in terapia umana |
US4301153A (en) | 1977-03-21 | 1981-11-17 | Riker Laboratories, Inc. | Heparin preparation |
DE2800943C2 (de) * | 1978-01-06 | 1984-09-27 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verwendung von Darm-Salzlake zur Gewinnung von reinem Heparin |
US4175182A (en) | 1978-07-03 | 1979-11-20 | Research Corporation | Separation of high-activity heparin by affinity chromatography on supported protamine |
CA1136620A (en) | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
DE2903701C2 (de) | 1979-01-31 | 1980-10-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Kontrollreagens für die Bestimmung der Heparinaktivität |
US4351938A (en) | 1980-05-19 | 1982-09-28 | Riker Laboratories, Inc. | Anticoagulant substance |
-
1982
- 1982-05-07 EP EP82200559A patent/EP0066908B1/en not_active Expired
- 1982-05-07 DE DE8282200559T patent/DE3265781D1/de not_active Expired
- 1982-05-07 AT AT82200559T patent/ATE15142T1/de not_active IP Right Cessation
- 1982-05-10 IE IE1118/82A patent/IE53255B1/en not_active IP Right Cessation
- 1982-05-11 ZA ZA823248A patent/ZA823248B/xx unknown
- 1982-05-12 US US06/377,581 patent/US4438108A/en not_active Expired - Lifetime
- 1982-05-19 PT PT74928A patent/PT74928B/pt not_active IP Right Cessation
- 1982-05-19 DK DK227282A patent/DK157061C/da not_active IP Right Cessation
- 1982-05-20 FI FI821804A patent/FI75491C/fi not_active IP Right Cessation
- 1982-05-20 CA CA000403376A patent/CA1186646A/en not_active Expired
- 1982-05-20 HU HU821620A patent/HU190687B/hu unknown
- 1982-05-20 NZ NZ200688A patent/NZ200688A/en unknown
- 1982-05-20 GR GR68206A patent/GR76794B/el unknown
- 1982-05-20 JP JP57085653A patent/JPS57197221A/ja active Granted
- 1982-05-21 AU AU83717/82A patent/AU550317B2/en not_active Ceased
- 1982-05-21 ES ES512464A patent/ES512464A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
IE821118L (en) | 1982-11-21 |
HU190687B (en) | 1986-10-28 |
CA1186646A (en) | 1985-05-07 |
DK227282A (da) | 1982-11-22 |
JPS57197221A (en) | 1982-12-03 |
GR76794B (es) | 1984-09-04 |
DK157061C (da) | 1990-04-09 |
AU8371782A (en) | 1982-11-25 |
EP0066908B1 (en) | 1985-08-28 |
EP0066908A1 (en) | 1982-12-15 |
FI821804A0 (fi) | 1982-05-20 |
PT74928B (en) | 1983-12-07 |
ZA823248B (en) | 1983-03-30 |
IE53255B1 (en) | 1988-09-28 |
AU550317B2 (en) | 1986-03-20 |
JPH0216733B2 (es) | 1990-04-18 |
NZ200688A (en) | 1985-10-11 |
DK157061B (da) | 1989-11-06 |
DE3265781D1 (en) | 1985-10-03 |
US4438108A (en) | 1984-03-20 |
PT74928A (en) | 1982-06-01 |
ATE15142T1 (de) | 1985-09-15 |
ES512464A0 (es) | 1983-07-01 |
FI75491C (fi) | 1988-07-11 |
FI75491B (fi) | 1988-03-31 |
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