HUP9701416A2 - Fenilszubsztituált alkenilkarbonsav-guanididek, eljárás azok előállítására, alkalmazásuk és az azokat tartalmazó gyógyszerkészítmények - Google Patents

Fenilszubsztituált alkenilkarbonsav-guanididek, eljárás azok előállítására, alkalmazásuk és az azokat tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9701416A2
HUP9701416A2 HU9701416A HUP9701416A HUP9701416A2 HU P9701416 A2 HUP9701416 A2 HU P9701416A2 HU 9701416 A HU9701416 A HU 9701416A HU P9701416 A HUP9701416 A HU P9701416A HU P9701416 A2 HUP9701416 A2 HU P9701416A2
Authority
HU
Hungary
Prior art keywords
guanidides
alkenyl
phenyl
substituted
producing
Prior art date
Application number
HU9701416A
Other languages
English (en)
Inventor
Joachim Brendel
Hans-Willi Jansen
Heinz-Werner Kleemann
Hans-Jochen Lang
Wolfgang Scholz
Jan-Robert Schwark
Andreas Weichert
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of HU9701416D0 publication Critical patent/HU9701416D0/hu
Publication of HUP9701416A2 publication Critical patent/HUP9701416A2/hu
Publication of HUP9701416A3 publication Critical patent/HUP9701416A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A találmány (I) általánős képletű vegyületekre vőantkőzik, ahől T jelentése (1) általánős képletű csőpőrt, ahől R(A), R(B), R(C), R(D),R(E) és R(F), valamint x és y jelentése az igénapőntők szerinti, valamint ezek gyógyászatilag elfőgadható sóira. A vegyületek a sejt nátriűm prőtőn antipőrter (Na+/H+-cserélő)inhibitőrai. Ezért alkalmasak őlyan betegségek kezelésére, amelyeket amegnövekedett Na+/H+ cserére lehet visszavezetni. ŕ
HU9701416A 1996-08-22 1997-08-19 Phenyl-substituted guanidides of alkenyl-carboxylic acids, process for producing them, and pharmaceutical compositions containing them HUP9701416A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19633966A DE19633966A1 (de) 1996-08-22 1996-08-22 Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (3)

Publication Number Publication Date
HU9701416D0 HU9701416D0 (en) 1997-10-28
HUP9701416A2 true HUP9701416A2 (hu) 1998-03-30
HUP9701416A3 HUP9701416A3 (en) 1998-07-28

Family

ID=7803413

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9701416A HUP9701416A3 (en) 1996-08-22 1997-08-19 Phenyl-substituted guanidides of alkenyl-carboxylic acids, process for producing them, and pharmaceutical compositions containing them

Country Status (29)

Country Link
US (1) US6005010A (hu)
EP (1) EP0825178B1 (hu)
JP (1) JP4081159B2 (hu)
KR (1) KR19980018898A (hu)
CN (1) CN1065861C (hu)
AR (1) AR008305A1 (hu)
AT (1) ATE202338T1 (hu)
AU (1) AU713664B2 (hu)
BR (1) BR9704483A (hu)
CA (1) CA2213714C (hu)
CZ (1) CZ265997A3 (hu)
DE (2) DE19633966A1 (hu)
DK (1) DK0825178T3 (hu)
ES (1) ES2158413T3 (hu)
GR (1) GR3036123T3 (hu)
HR (1) HRP970450B1 (hu)
HU (1) HUP9701416A3 (hu)
ID (1) ID18066A (hu)
IL (1) IL121590A (hu)
MX (1) MX9706380A (hu)
NO (1) NO309468B1 (hu)
NZ (1) NZ328639A (hu)
PL (1) PL321748A1 (hu)
PT (1) PT825178E (hu)
RU (1) RU2193026C2 (hu)
SI (1) SI0825178T1 (hu)
SK (1) SK282632B6 (hu)
TR (1) TR199700827A2 (hu)
ZA (1) ZA977494B (hu)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19849722A1 (de) * 1998-10-28 2000-05-04 Aventis Pharma Gmbh Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
AU4707900A (en) * 1999-05-07 2000-11-21 Trustees Of The University Of Pennsylvania, The Methods for controlling intraocular pressure
DE19960204A1 (de) * 1999-12-14 2001-06-28 Aventis Pharma Gmbh Substituierte Norlbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10015248A1 (de) * 2000-03-28 2001-10-04 Merck Patent Gmbh Bisamidino-Verbindungen als NHE-3 Inhibitoren
DE10046993A1 (de) * 2000-09-22 2002-04-11 Aventis Pharma Gmbh Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
DE10063294A1 (de) 2000-12-19 2002-07-04 Aventis Pharma Gmbh Substituierte Heterocyclo-Norbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10161767A1 (de) * 2001-12-15 2003-06-26 Merck Patent Gmbh 2-Guanidino-4-heterocyclyl-chinazoline
DE10163239A1 (de) * 2001-12-21 2003-07-10 Aventis Pharma Gmbh Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament
US20030187045A1 (en) * 2001-12-21 2003-10-02 Uwe Heinelt Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic
US7049333B2 (en) 2002-06-04 2006-05-23 Sanofi-Aventis Deutschland Gmbh Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis
DE10304374A1 (de) * 2003-02-04 2004-08-05 Aventis Pharma Deutschland Gmbh Neue substituierte 2-Aminoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US20050054705A1 (en) * 2003-02-04 2005-03-10 Aventis Pharma Deutschland Gmbh N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE10341240A1 (de) 2003-09-08 2005-04-07 Aventis Pharma Deutschland Gmbh Substituierte Thienoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE102005001411A1 (de) 2005-01-12 2006-07-27 Sanofi-Aventis Deutschland Gmbh Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
ATE479679T1 (de) 2007-06-28 2010-09-15 Sanofi Aventis Us Llc Verfahren zur herstellung von n-(2-chlor-4-methyl-3-thienyl)-1h-benzimidazol- 2-amin hydrochlorid und zwischenprodukte dafür
KR101169862B1 (ko) * 2007-10-26 2012-07-31 제이에스알 가부시끼가이샤 액정 배향제, 액정 배향막의 형성 방법 및 액정 표시 소자
US8822449B2 (en) 2008-09-02 2014-09-02 Sanofi Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof
WO2010078449A2 (en) 2008-12-31 2010-07-08 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US20120088737A2 (en) * 2009-10-02 2012-04-12 Ajinomoto Co., Inc Novel acyl guanidine derivatives
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
CN104902930A (zh) 2012-08-21 2015-09-09 阿德利克斯公司 在治疗与液体潴留或盐分过载相关的疾病和胃肠道疾病中用于抑制nhe-介导的反向转运的化合物和方法
HUE044550T2 (hu) 2013-04-12 2019-11-28 Ardelyx Inc NHE-3 megkötõ vegyületek és foszfát transzport gátlási módszerek
CN110267944B (zh) 2017-01-09 2024-03-08 阿德利克斯股份有限公司 可用于治疗胃肠道病症的化合物
JP2020505333A (ja) 2017-01-09 2020-02-20 アルデリックス， インコーポレイテッド Ｎｈｅ媒介性アンチポートの阻害薬
EP3661945B1 (en) 2017-08-04 2024-04-03 Ardelyx, Inc. Glycyrrhetinic acid derivatives for treating hyperkalemia
JP2022519714A (ja) 2019-02-07 2022-03-24 アルデリックス， インコーポレイテッド 高カリウム血症の治療で使用するためのグリチルレチン酸誘導体
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544670A (en) * 1982-08-24 1985-10-01 William H. Rorer, Inc. Method of treating coccidiosis with acyl guanidines
DE4328352A1 (de) * 1993-08-24 1995-03-02 Hoechst Ag Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4421536A1 (de) * 1994-06-20 1995-12-21 Hoechst Ag Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
AU713664B2 (en) 1999-12-09
US6005010A (en) 1999-12-21
CN1174833A (zh) 1998-03-04
EP0825178B1 (de) 2001-06-20
JPH10109970A (ja) 1998-04-28
TR199700827A2 (xx) 1998-03-21
SI0825178T1 (en) 2001-10-31
HU9701416D0 (en) 1997-10-28
SK113897A3 (en) 1998-03-04
NO973850L (no) 1998-02-23
IL121590A0 (en) 1998-02-08
DE19633966A1 (de) 1998-02-26
PL321748A1 (en) 1998-03-02
CN1065861C (zh) 2001-05-16
CA2213714A1 (en) 1998-02-22
SK282632B6 (sk) 2002-10-08
CA2213714C (en) 2007-08-14
DE59703851D1 (de) 2001-07-26
MX9706380A (es) 1998-02-28
IL121590A (en) 2002-05-23
AU3519297A (en) 1998-02-26
ZA977494B (en) 1998-02-23
AR008305A1 (es) 1999-12-29
PT825178E (pt) 2001-10-30
RU2193026C2 (ru) 2002-11-20
HRP970450B1 (en) 2003-02-28
KR19980018898A (ko) 1998-06-05
DK0825178T3 (da) 2001-09-03
NO973850D0 (no) 1997-08-21
NO309468B1 (no) 2001-02-05
HRP970450A2 (en) 1998-08-31
ES2158413T3 (es) 2001-09-01
CZ265997A3 (cs) 1998-03-18
ATE202338T1 (de) 2001-07-15
HUP9701416A3 (en) 1998-07-28
GR3036123T3 (en) 2001-09-28
JP4081159B2 (ja) 2008-04-23
NZ328639A (en) 1999-01-28
ID18066A (id) 1998-02-26
BR9704483A (pt) 1998-12-29
EP0825178A1 (de) 1998-02-25

Similar Documents

Publication Publication Date Title
HUP9701416A2 (hu) Fenilszubsztituált alkenilkarbonsav-guanididek, eljárás azok előállítására, alkalmazásuk és az azokat tartalmazó gyógyszerkészítmények
HUP9902121A2 (hu) Gonadotropin-leadó hormon antagonista hatású indolszármazékok és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
ATE2427T1 (de) (dl)-16-phenoxy- und 16-substituierte phenoxy-9- keto prostatriensaeuren und derivate, verfahren zu deren herstellung und ihre pharmazeutischen zusammensetzungen.
NO154089C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolderivater.
FR2438654A1 (fr) Compose de 2-methyl-dihydropyridine, procedes pour son obtention et composition pharmaceutique contenant ce compose
MY113803A (en) Fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as medicament or diagnostic, and medicament containing them.
MY115805A (en) Substituted benzyloxycarbonylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
TNSN90021A1 (fr) Procede de preparation de tetrahydroimidazo (1,4) benzodiazepin -2- thiones antivirales
HU9303000D0 (en) Aryl-morpholine-derivatives and pharmaceutical compositions containing it and process for production thereof
FR2432520A1 (fr) Nouvelles imidazoquinoxalines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
TR200101083T2 (tr) (7alfa,17alfa)-17-hidroksi- 7-metil-19-nor-17-pregn-5 (10)-en-20-in-3-on içeren yüksek saflıkta bileşim.
DE3769563D1 (de) Neue derivate von 4,5-dihydro-oxazolen, verfahren zu ihrer herstellung und ihre verwendung.
ATE122662T1 (de) Cycloakylenazole, verfahren zu deren herstellung, pharmazeutische präparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln.
ATE40127T1 (de) 1,5-benzothiazepinderivate, verfahren zu ihrer herstellung und arzneimittel.
ES480113A1 (es) Procedimiento para la preparacion de nuevos derivados de 2- iminoimidazolidina.
EP0066909A3 (en) Imidazole derivatives, pharmaceutical compositions containing them and processes for their production
ES8802612A1 (es) Procedimiento para preparar derivados de benzisoselenazolilo
ATE56707T1 (de) Imidazolverbindungen, verfahren zu deren herstellung und deren pharmazeutische zusammensetzungen.
ES8802311A1 (es) Procedimiento de preparacion de derivados del triazol y de sus sales de adicion con los acidos apropiados
HUP9801925A1 (hu) Nátrium/hidrogén-csere inhibítorok alkalmazása protozoák által okozott betegségek kezelésére alkalmas gyógyszerkészítmények előállítására
ES472591A1 (es) Procedimiento para la obtencion de derivados de 1-fenileta- nolamina
DK0541726T3 (da) Vækstfaktorsammensætninger, fremstilling og anvendelse
ES8300747A1 (es) Procedimiento para la preparacion de derivados de acido in- dolacetico
ES481271A1 (es) Procedimiento de preparacion de derivados de la l-cisteina.
ES8305319A1 (es) "procedimiento para la preparacion de acidos antranilicos sustituidos con radicales basicos"