FR2438654A1 - Compose de 2-methyl-dihydropyridine, procedes pour son obtention et composition pharmaceutique contenant ce compose - Google Patents

Compose de 2-methyl-dihydropyridine, procedes pour son obtention et composition pharmaceutique contenant ce compose

Info

Publication number
FR2438654A1
FR2438654A1 FR7925007A FR7925007A FR2438654A1 FR 2438654 A1 FR2438654 A1 FR 2438654A1 FR 7925007 A FR7925007 A FR 7925007A FR 7925007 A FR7925007 A FR 7925007A FR 2438654 A1 FR2438654 A1 FR 2438654A1
Authority
FR
France
Prior art keywords
same
methyl
methods
pharmaceutical composition
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7925007A
Other languages
English (en)
Other versions
FR2438654B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of FR2438654A1 publication Critical patent/FR2438654A1/fr
Application granted granted Critical
Publication of FR2438654B1 publication Critical patent/FR2438654B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NOUVEAU COMPOSE DE 2-METHYL-DIHYDROPYRIDINE, AINSI QUE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES. IL REPOND A LA FORMULE SUIVANTE: (CF DESSIN DANS BOPI) DONT LES DEFINITIONS DES SUBSTITUANTS SONT DONNEES DANS LA DEMANDE. LES SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CE COMPOSE, QUI POSSEDENT DES PROPRIETES VASODILATATRICES ET HYPOTENSIVES, SONT UTILISABLES DANS DES COMPOSITIONS PHARMACEUTIQUES POUR LE TRAITEMENT DES MALADIES CARDIOVASCULAIRES ET DE L'HYPERTENSION.
FR7925007A 1978-10-10 1979-10-08 Compose de 2-methyl-dihydropyridine, procedes pour son obtention et composition pharmaceutique contenant ce compose Granted FR2438654A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7839978 1978-10-10

Publications (2)

Publication Number Publication Date
FR2438654A1 true FR2438654A1 (fr) 1980-05-09
FR2438654B1 FR2438654B1 (fr) 1983-01-14

Family

ID=10500226

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7925007A Granted FR2438654A1 (fr) 1978-10-10 1979-10-08 Compose de 2-methyl-dihydropyridine, procedes pour son obtention et composition pharmaceutique contenant ce compose

Country Status (10)

Country Link
JP (2) JPS5562065A (fr)
BE (1) BE879263A (fr)
CA (1) CA1117117A (fr)
CH (1) CH642353A5 (fr)
DE (1) DE2940833A1 (fr)
FR (1) FR2438654A1 (fr)
GB (1) GB2036722B (fr)
IT (1) IT1125469B (fr)
NL (1) NL7907482A (fr)
SE (2) SE446265B (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063359A1 (fr) * 1981-04-18 1982-10-27 Banyu Pharmaceutical Co., Ltd. Dérivés de 1,4-dihydropyridine et leurs procédés de préparation
EP0080220A1 (fr) * 1981-11-17 1983-06-01 FISONS plc Dihydropyridines, leur procédé de préparation, leurs compositions et leur application comme médicaments
FR2523128A1 (fr) * 1982-03-10 1983-09-16 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et medicaments contenant ces derives
FR2532648A1 (fr) * 1982-09-03 1984-03-09 Otsuka Pharma Co Ltd Derives de carbostyrile, leur procede de preparation et leur application en therapeutique
EP0185283A2 (fr) * 1984-12-10 1986-06-25 Fujisawa Pharmaceutical Co., Ltd. Utilisation de dihydropyridines pour le traitement et la prévention de l'artériosclérose
EP0322747A2 (fr) * 1987-12-29 1989-07-05 Fujisawa Pharmaceutical Co., Ltd. Agent protégeant les neurones cérébraux contenant un dérivé de la dihydropyridine

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7910521L (sv) * 1979-12-20 1981-06-21 Haessle Ab Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma
DE3312216A1 (de) * 1983-04-05 1984-10-11 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von symmetrischen 1,4-dihydropyridincarbonsaeureestern
JPS6038322A (ja) * 1983-08-11 1985-02-27 Fujisawa Pharmaceut Co Ltd ジヒドロピリジンａ物質含有易溶性固形製剤
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
GB8602518D0 (en) * 1986-02-01 1986-03-05 Wyeth John & Brother Ltd 1 4-dihydropyridines
JPS63115890A (ja) * 1986-10-31 1988-05-20 Nippon Shinyaku Co Ltd ２位置換１，４−ジヒドロピリジン誘導体
US5114946A (en) * 1987-06-12 1992-05-19 American Cyanamid Company Transdermal delivery of pharmaceuticals
ES2043719T3 (es) * 1987-06-12 1994-01-01 American Cyanamid Co Administracion de farmacos por via percutanea.
US5045553A (en) * 1987-06-24 1991-09-03 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter
CA1318596C (fr) * 1987-12-29 1993-06-01 Takaharu Ono Agent de suppression de l'hypertrophie cardiaque et d'amelioration de l'elasticite du reseau veineux, contenant un compose du type dihydropyridine
JP2007230869A (ja) * 2004-04-05 2007-09-13 Takeda Chem Ind Ltd アルドステロン受容体拮抗剤
CN101987833B (zh) * 2009-08-04 2014-07-30 北京利乐生制药科技有限公司 尼伐地平晶型及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2315930A1 (fr) * 1975-07-02 1977-01-28 Fujisawa Pharmaceutical Co Derives de 1,4-dihydropyridine et leur procede de preparation
FR2374307A1 (fr) * 1976-12-17 1978-07-13 Fujisawa Pharmaceutical Co Derives de la 1,4-dihydropyridine, leur procede d'obtention et composition pharmaceutique les contenant
FR2378763A1 (fr) * 1976-12-22 1978-08-25 Bayer Ag Nouveaux derives de 1,4-dihydropyridine substitues en position 2, leur procede de preparation et medicament les contenant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2315930A1 (fr) * 1975-07-02 1977-01-28 Fujisawa Pharmaceutical Co Derives de 1,4-dihydropyridine et leur procede de preparation
FR2374307A1 (fr) * 1976-12-17 1978-07-13 Fujisawa Pharmaceutical Co Derives de la 1,4-dihydropyridine, leur procede d'obtention et composition pharmaceutique les contenant
FR2378763A1 (fr) * 1976-12-22 1978-08-25 Bayer Ag Nouveaux derives de 1,4-dihydropyridine substitues en position 2, leur procede de preparation et medicament les contenant

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063359A1 (fr) * 1981-04-18 1982-10-27 Banyu Pharmaceutical Co., Ltd. Dérivés de 1,4-dihydropyridine et leurs procédés de préparation
EP0080220A1 (fr) * 1981-11-17 1983-06-01 FISONS plc Dihydropyridines, leur procédé de préparation, leurs compositions et leur application comme médicaments
FR2523128A1 (fr) * 1982-03-10 1983-09-16 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et medicaments contenant ces derives
FR2532648A1 (fr) * 1982-09-03 1984-03-09 Otsuka Pharma Co Ltd Derives de carbostyrile, leur procede de preparation et leur application en therapeutique
EP0185283A2 (fr) * 1984-12-10 1986-06-25 Fujisawa Pharmaceutical Co., Ltd. Utilisation de dihydropyridines pour le traitement et la prévention de l'artériosclérose
EP0185283A3 (en) * 1984-12-10 1989-07-19 Fujisawa Pharmaceutical Co., Ltd. Use of dihydropyridines for the treatment and prevention of arteriosclerosis
EP0322747A2 (fr) * 1987-12-29 1989-07-05 Fujisawa Pharmaceutical Co., Ltd. Agent protégeant les neurones cérébraux contenant un dérivé de la dihydropyridine
EP0322747A3 (fr) * 1987-12-29 1991-07-24 Fujisawa Pharmaceutical Co., Ltd. Agent protégeant les neurones cérébraux contenant un dérivé de la dihydropyridine

Also Published As

Publication number Publication date
FR2438654B1 (fr) 1983-01-14
IT7926362A0 (it) 1979-10-09
BE879263A (fr) 1980-04-08
DE2940833A1 (de) 1980-04-30
SE446265B (sv) 1986-08-25
SE8400689D0 (sv) 1984-02-09
CH642353A5 (de) 1984-04-13
CA1117117A (fr) 1982-01-26
DE2940833C2 (fr) 1989-01-26
NL7907482A (nl) 1980-04-14
IT1125469B (it) 1986-05-14
JPS5562065A (en) 1980-05-10
SE7908367L (sv) 1980-04-11
SE8400689L (sv) 1984-02-09
GB2036722B (en) 1982-12-01
JPS61118366A (ja) 1986-06-05
GB2036722A (en) 1980-07-02
SE446096B (sv) 1986-08-11
JPS6143343B2 (fr) 1986-09-26
JPS6125711B2 (fr) 1986-06-17

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