KR880011199A - 신규 펩타이드 화합물, 그의 제조방법 및 그를 함유하는 약학적 조성물 - Google Patents

신규 펩타이드 화합물, 그의 제조방법 및 그를 함유하는 약학적 조성물 Download PDF

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KR880011199A
KR880011199A KR1019880003292A KR880003292A KR880011199A KR 880011199 A KR880011199 A KR 880011199A KR 1019880003292 A KR1019880003292 A KR 1019880003292A KR 880003292 A KR880003292 A KR 880003292A KR 880011199 A KR880011199 A KR 880011199A
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South Korea
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group
lower alkyl
substance
optionally substituted
alkyl
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KR1019880003292A
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English (en)
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게이지 헤미
아사히로 네야
게이스게 이마이
나스고 가야기리
모도 마사시 하시
Original Assignee
후지사와 도모 기지로오
후지사와 약구힝 고교 가부시끼 가이샤
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Publication of KR880011199A publication Critical patent/KR880011199A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용없음

Description

신규 펩타이드 화합물, 그의 제조방법 및 그를 함유하는 약학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 다음 구조식으로 표시된 물질 및 그의 제조방법과 그것으로 된 약제의 투여방법.
    위에서 R1는 할로겐 또는 할로(저급)알킬로 구성된 그룹으로부터 선택된 치환기가 선택적으로 치환될 수 있는 것.
    R2는 하이드로겐 또는 저급 알킬, 또는 R1및 R2는 저급 알킬 및 에스테르화 카복실로 구성된 그룹으로부터 선택된 치환기가 선택적으로 치환되어 헤테로사이크릭 그룹을 형성하기 위해 부착된 질소원자를 같이 취한 것이다. R3는 하이드로겐 혹은 저급 알킬는 저급 알킬이다.
  2. 제1항에 있어서 R1및 R2가 저급 알킬 및 에스테르화 카복실로 구성된 그룹으로부터 선택된 치환기가 선택적으로 치환되어 헤테로시이크릭 그룹을 형성하기 위해 부착된 질소원자를 같이 취하는 기로된 물질.
  3. 제1항에 있어서, R1및 R2가 몰포리노, 디오노포리노, 피로리된-1-y1, 피퍼리티노, 피레라진-1-y1, 피로린-1-y1, 1,4-디하이드로피리딘-1-y1, 1,2,3,6-테트라하이드로필딘-1-y1, 1,2,3,4-테트라하이드로소퀴노린-2-y1또는 1,2,3,4-테트라하이드로퀴노린-1-y1을 형성하기 위해 질소원자를 부착시키고 동시에 취한 것으로 이것들의 개개는 저급 알킬 및 저급 알콕시카보닐로 구성된 그룹으로부터 치환기가 선택적으로 치환될 수 있는 기로된 물질.
  4. 제1항에 있어서이 물질이 (S)-(N-모포리노카보닐-L-페닐알라아닐-Na-메틸-L-히스티딜)아미노-1-시크로헥실-3(S)-하이드록시-6-메틸헵탄 또는 하아드로크로라이드인 것.
  5. 제1항에 있어서 다음 구조식(Ⅱ) 화합물 및 그의 염기를 구조식Ⅲ 화합물 및 그의 염기로 반응시켜 구조식I 화합물 및 그의 염기를 제조하는 방법.
    여기서 R1은 할로겐 및 할로(저급)-알킬, 저급 알킬 혹은 싸이클로(저급)알킬로 구성된 그룹으로부터 선택된 치환기가 선택적으로 치한된 것이며, 또한 R2는 질소 혹은 저급 알킬, 혹은, R1및 R2는 저급알킬 및 에스테르화 카복실로 구성된 그룹으로부터 선택적으로 선택된 치환기가 선택적으로 치환되어 헤테로시 이크릭그룹을 형성키 위해 부착된 질소원자같이 취해진 것이다.
    R3는 질소 혹은 저급 알킬, 및 R4는 저급 알킬,
    여기서 R6는 질소 혹은 N-보호 그룹, 그리고 R3및 R4는 각각 위에서 정의된 바와 같으며, 혹은 구조식의 물질과 아미노그룹 혹은 그 염기에서 반응 유도물질이다.
    여기서 R1및 R2는 각각 위에서 정이된 바와 같으며, 혹은 카복시 그룹 혹은 그 염기에서 그 반응물질, 또는 만약 필요하면, N-보호 그룹을 환원함.
  6. 제1항에 있어서 제1항에 물질 또는 그의 염을 주성분으로 하고 이에 약학적으로 적합하고 비독성물질 및 부형제로 조성된 사람이나 동물에 투여되는 고혈압치료제.
  7. 제1항에 있어서 제1항의 물질이 약물로써 사용하는 것.
  8. 제1항에 있어서 제1항의 물질과 그 염을 동물이나 인간의 고혈압을 치료하는 치료방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880003292A 1987-03-27 1988-03-26 신규 펩타이드 화합물, 그의 제조방법 및 그를 함유하는 약학적 조성물 KR880011199A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878707412A GB8707412D0 (en) 1987-03-27 1987-03-27 Peptide compounds
GB87-07412 1987-03-27

Publications (1)

Publication Number Publication Date
KR880011199A true KR880011199A (ko) 1988-10-27

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Country Link
US (1) US4963530A (ko)
EP (1) EP0283970A3 (ko)
JP (1) JP2536032B2 (ko)
KR (1) KR880011199A (ko)
GB (1) GB8707412D0 (ko)

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GB8707412D0 (en) 1987-04-29
US4963530A (en) 1990-10-16
JP2536032B2 (ja) 1996-09-18
JPS63253097A (ja) 1988-10-20
EP0283970A2 (en) 1988-09-28
EP0283970A3 (en) 1989-09-20

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