ATE60759T1 - Bisdimethoxymethyl(trimethoxybenzyl)isochinolinium salze, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

Bisdimethoxymethyl(trimethoxybenzyl)isochinolinium salze, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Info

Publication number
ATE60759T1
ATE60759T1 AT85305097T AT85305097T ATE60759T1 AT E60759 T1 ATE60759 T1 AT E60759T1 AT 85305097 T AT85305097 T AT 85305097T AT 85305097 T AT85305097 T AT 85305097T AT E60759 T1 ATE60759 T1 AT E60759T1
Authority
AT
Austria
Prior art keywords
isochinolinium
bisdimethoxymethyl
trimethoxybenzyl
salts
preparation
Prior art date
Application number
AT85305097T
Other languages
English (en)
Inventor
Roy Archibald Swaringen Jr
Hassan Ali El-Sayad
David Arthur Yeowell
John Joseph Savarese
Original Assignee
Wellcome Found
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found, Gen Hospital Corp filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE60759T1 publication Critical patent/ATE60759T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Jib Cranes (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Cosmetics (AREA)
AT85305097T 1984-07-18 1985-07-17 Bisdimethoxymethyl(trimethoxybenzyl)isochinolinium salze, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen. ATE60759T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848418303A GB8418303D0 (en) 1984-07-18 1984-07-18 Compounds
EP85305097A EP0181055B1 (de) 1984-07-18 1985-07-17 Bis-dimethoxymethyl(trimethoxybenzyl)isochinolinium-Salze, ihre Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
ATE60759T1 true ATE60759T1 (de) 1991-02-15

Family

ID=10564058

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85305097T ATE60759T1 (de) 1984-07-18 1985-07-17 Bisdimethoxymethyl(trimethoxybenzyl)isochinolinium salze, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (30)

Country Link
US (1) US4761418A (de)
EP (1) EP0181055B1 (de)
JP (1) JPH0662568B2 (de)
AT (1) ATE60759T1 (de)
AU (1) AU574481B2 (de)
BG (1) BG60411B2 (de)
CA (1) CA1273341A (de)
CY (1) CY1687A (de)
DD (1) DD235638A5 (de)
DE (2) DE3581699D1 (de)
DK (1) DK168093B1 (de)
ES (1) ES8609260A1 (de)
FI (1) FI85019C (de)
GB (1) GB8418303D0 (de)
GE (1) GEP19960468B (de)
HK (1) HK47593A (de)
HU (1) HU193996B (de)
IE (1) IE58138B1 (de)
IL (1) IL75833A (de)
LT (1) LT2078B (de)
LU (1) LU88801I2 (de)
LV (1) LV5483A3 (de)
MC (1) MC1690A1 (de)
MX (1) MX9203667A (de)
NL (1) NL940023I2 (de)
NZ (1) NZ212766A (de)
PL (1) PL146066B1 (de)
SG (1) SG3493G (de)
SU (1) SU1468414A3 (de)
ZA (1) ZA855407B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
IL131918A (en) * 1997-03-25 2005-09-25 Cornell Res Foundation Inc Substituted isoquinolines as ultra short acting neuromuscular blockers
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
US20050192243A1 (en) * 2003-10-28 2005-09-01 Savarese John J. Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) * 2006-06-20 2011-01-18 Farmabios S.P.A. Process for the preparation of mivacurium chloride
ATE554769T1 (de) * 2006-12-06 2012-05-15 Cornell Res Foundation Inc Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
WO2008107887A2 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
WO2008117271A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
WO2008132746A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
US8293912B2 (en) * 2007-05-01 2012-10-23 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
BRPI0811687A2 (pt) * 2007-06-18 2015-02-18 Chemagis Ltd MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO
BRPI0812625A2 (pt) * 2007-07-09 2019-02-19 Chemagis Ltd processo para preparar um sal de cis-atracúrio
US8354537B2 (en) * 2007-10-29 2013-01-15 Chemagis Ltd. R,R1-atracurium salts
ITMI20080319A1 (it) * 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
WO2009133556A2 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
CN102573794B (zh) 2009-08-19 2017-03-15 康奈尔大学 供生理注射用的半胱氨酸
WO2013021398A2 (en) * 2011-08-05 2013-02-14 Sequent Scientific Limited A process for preparation of mivacurium chloride
EP2867219B1 (de) * 2012-06-29 2017-02-15 Cornell University Asymmetrische reversible neuromuskuläre blockiermittel von sehr kurzen, kurzer oder mittellanger dauer
CN103373959A (zh) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 顺式苄基异喹啉类化合物的制备方法及其用途
CN107782821B (zh) * 2016-08-26 2021-11-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂的分析方法
CN107778237A (zh) * 2016-08-26 2018-03-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN108938573B (zh) * 2017-05-26 2021-08-10 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) * 2017-09-30 2018-09-07 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) * 2019-07-29 2022-04-29 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) * 2019-11-11 2021-03-09 武汉大安制药有限公司 一种5’-甲氧基劳丹素的拆分方法
CN116410078A (zh) * 2021-12-29 2023-07-11 苏州特瑞药业股份有限公司 一种制备(e)-辛-4-烯-1,8-二酸的方法
WO2025140288A1 (zh) * 2023-12-25 2025-07-03 上海森辉医药有限公司 一种四氢异喹啉及其药物用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB863717A (en) * 1958-07-03 1961-03-22 Allen & Hanburys Ltd Tetrahydropapaverine derivatives and their preparation
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
US4192877A (en) * 1977-08-01 1980-03-11 Massachusetts General Hospital Neuromuscular blocking agents
FI782363A7 (fi) * 1977-08-01 1979-02-02 Massachusetts Gen Hospital Nerv-muskel-blockeringsaemne
US4235906A (en) * 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
CA1153380A (en) * 1979-10-19 1983-09-06 Hassan A. El-Sayad Neuromuscular blocking tetrahydroisoquinolinium salts
DE3165714D1 (en) * 1980-12-17 1984-09-27 Wellcome Found Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) * 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体

Also Published As

Publication number Publication date
LT2078B (lt) 1993-06-15
US4761418A (en) 1988-08-02
GEP19960468B (en) 1996-08-29
DE3581699D1 (de) 1991-03-14
FI85019C (fi) 1992-02-25
GB8418303D0 (en) 1984-08-22
IL75833A0 (en) 1985-11-29
IL75833A (en) 1988-11-30
IE851791L (en) 1986-01-18
LV5483A3 (lv) 1994-03-10
DK324985D0 (da) 1985-07-17
AU4510885A (en) 1986-01-23
MX9203667A (es) 1992-07-31
NZ212766A (en) 1988-03-30
BG60411B2 (bg) 1995-02-28
NL940023I1 (nl) 1995-01-02
ES545319A0 (es) 1986-09-01
FI852807L (fi) 1986-01-19
DK324985A (da) 1986-01-19
PL254571A1 (en) 1986-07-15
HK47593A (en) 1993-05-21
IE58138B1 (en) 1993-07-14
JPS6187666A (ja) 1986-05-06
SG3493G (en) 1993-03-12
EP0181055A1 (de) 1986-05-14
JPH0662568B2 (ja) 1994-08-17
SU1468414A3 (ru) 1989-03-23
FI85019B (fi) 1991-11-15
HUT40626A (en) 1987-01-28
ES8609260A1 (es) 1986-09-01
HU193996B (en) 1987-12-28
CY1687A (en) 1993-10-10
PL146066B1 (en) 1988-12-31
DD235638A5 (de) 1986-05-14
NL940023I2 (nl) 1998-06-02
LU88801I2 (fr) 1996-11-05
ZA855407B (en) 1986-04-30
EP0181055B1 (de) 1991-02-06
DE19675039I2 (de) 2003-01-09
MC1690A1 (fr) 1986-07-18
CA1273341A (en) 1990-08-28
AU574481B2 (en) 1988-07-07
FI852807A0 (fi) 1985-07-17
DK168093B1 (da) 1994-02-07

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