ATE41772T1 - Polymethoxybenzyl-piperazin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende pharmazeutische zusammensetzungen. - Google Patents
Polymethoxybenzyl-piperazin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende pharmazeutische zusammensetzungen.Info
- Publication number
- ATE41772T1 ATE41772T1 AT84114930T AT84114930T ATE41772T1 AT E41772 T1 ATE41772 T1 AT E41772T1 AT 84114930 T AT84114930 T AT 84114930T AT 84114930 T AT84114930 T AT 84114930T AT E41772 T1 ATE41772 T1 AT E41772T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- polymethoxybenzyl
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58233404A JPS60155171A (ja) | 1983-12-10 | 1983-12-10 | ポリメトキシベンジルピペラジン誘導体 |
EP84114930A EP0144991B1 (de) | 1983-12-10 | 1984-12-07 | Polymethoxybenzyl-Piperazin-Derivate, Verfahren zu ihrer Herstellung und diese Derivate enthaltende pharmazeutische Zusammensetzungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE41772T1 true ATE41772T1 (de) | 1989-04-15 |
Family
ID=16954540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT84114930T ATE41772T1 (de) | 1983-12-10 | 1984-12-07 | Polymethoxybenzyl-piperazin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende pharmazeutische zusammensetzungen. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4574156A (de) |
EP (1) | EP0144991B1 (de) |
JP (1) | JPS60155171A (de) |
AT (1) | ATE41772T1 (de) |
CA (1) | CA1227209A (de) |
DE (1) | DE3477488D1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8705574D0 (en) * | 1987-03-10 | 1987-04-15 | Ici Plc | Preparation of thiazepine compound |
US5098755A (en) * | 1990-11-21 | 1992-03-24 | Tanquary Albert C | Textured thermoplastic elastomeric film, articles comprising same, and method of making such textured thermoplastic elastomeric film and articles |
AU646926B2 (en) * | 1991-03-20 | 1994-03-10 | Duphar International Research B.V. | Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity |
DE69426157T2 (de) * | 1993-07-28 | 2001-05-17 | Santen Pharmaceutical Co Ltd | 1,4-di(phenylalkyl)piperazinderivate |
JP2020514461A (ja) | 2016-12-27 | 2020-05-21 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | ポリウレタンフォーム物品及びポリウレタンフォーム物品を形成する方法 |
PL3641769T3 (pl) * | 2017-06-20 | 2022-09-26 | Imbria Pharmaceuticals, Inc. | Pochodna 1-[(2,3,4-trimetoksyfenylo)metylo]piperazyny, jej kompozycje oraz sposoby zwiększania wydajności metabolizmu serca |
EP3866794A4 (de) * | 2018-10-17 | 2022-07-20 | Imbria Pharmaceuticals, Inc. | Verfahren zur behandlung von rheumatischen erkrankungen unter verwendung von trimetazidinbasierten verbindungen |
US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11730733B2 (en) | 2020-12-10 | 2023-08-22 | Imbria Pharmaceuticals, Inc. | Methods of treating non-obstructive hypertrophic cardiomyopathy using modified forms of trimetazidine |
US11793807B2 (en) | 2020-12-10 | 2023-10-24 | Imbria Pharmaceuticals, Inc. | Methods of treating heart failure with preserved ejection fraction using modified forms of trimetazidine |
US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE523903A (de) * | ||||
US2995553A (en) * | 1960-01-25 | 1961-08-08 | Abbott Lab | Substituted piperazines |
US4100285A (en) * | 1976-04-09 | 1978-07-11 | Nippon Shinyaku Co., Ltd. | N-substituted trialkoxybenzyl piperazine derivatives |
JPS6154474A (ja) * | 1984-08-25 | 1986-03-18 | Fuji Electric Co Ltd | 電力量計の試験装置 |
-
1983
- 1983-12-10 JP JP58233404A patent/JPS60155171A/ja active Granted
-
1984
- 1984-12-05 CA CA000469359A patent/CA1227209A/en not_active Expired
- 1984-12-07 EP EP84114930A patent/EP0144991B1/de not_active Expired
- 1984-12-07 US US06/679,346 patent/US4574156A/en not_active Expired - Fee Related
- 1984-12-07 DE DE8484114930T patent/DE3477488D1/de not_active Expired
- 1984-12-07 AT AT84114930T patent/ATE41772T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0144991A3 (en) | 1985-07-17 |
US4574156A (en) | 1986-03-04 |
EP0144991A2 (de) | 1985-06-19 |
CA1227209A (en) | 1987-09-22 |
JPH0333155B2 (de) | 1991-05-16 |
EP0144991B1 (de) | 1989-03-29 |
DE3477488D1 (en) | 1989-05-03 |
JPS60155171A (ja) | 1985-08-15 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |