GB863717A - Tetrahydropapaverine derivatives and their preparation - Google Patents

Tetrahydropapaverine derivatives and their preparation

Info

Publication number
GB863717A
GB863717A GB2139558A GB2139558A GB863717A GB 863717 A GB863717 A GB 863717A GB 2139558 A GB2139558 A GB 2139558A GB 2139558 A GB2139558 A GB 2139558A GB 863717 A GB863717 A GB 863717A
Authority
GB
United Kingdom
Prior art keywords
tetrahydropapaverine
preparation
alkyl
bromalkyl
dicarboxylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2139558A
Inventor
Edwin Percival Taylor
Henry Oswald Jackson Collier
Jan Mieczyslaw Zygmunt Gladych
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Priority to GB2139558A priority Critical patent/GB863717A/en
Publication of GB863717A publication Critical patent/GB863717A/en
Expired legal-status Critical Current

Links

Abstract

The invention comprises compounds of the formula: <FORM:0863717/IV (b)/1> wherein R is alkyl of less than 7 carbon atoms, X is an anion, m is 2 or 3, and n is 0, 1, 2, 3 or 4, and processes for their preparation: (a) by refluxing an excess of an N-alkyl-tetrahydropapaverine with an o -bromalkyl dicarboxylate in an inert solvent for a prolonged period giving compounds of the above formula in which X is bromine; and (b) by reacting an o -bromalkyl dicarboxylate with tetrahydropapaverine in the presence of an acid-binding agent and treating the product with at least two molecular proportions of an alkyl halide or alkyl sulphate. Examples detail the preparation of thirteen dibromide, di-iodide, diperchlorate and dinitrate salts of the above formula.
GB2139558A 1958-07-03 1958-07-03 Tetrahydropapaverine derivatives and their preparation Expired GB863717A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2139558A GB863717A (en) 1958-07-03 1958-07-03 Tetrahydropapaverine derivatives and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2139558A GB863717A (en) 1958-07-03 1958-07-03 Tetrahydropapaverine derivatives and their preparation

Publications (1)

Publication Number Publication Date
GB863717A true GB863717A (en) 1961-03-22

Family

ID=10162200

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2139558A Expired GB863717A (en) 1958-07-03 1958-07-03 Tetrahydropapaverine derivatives and their preparation

Country Status (1)

Country Link
GB (1) GB863717A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010119A1 (en) * 1978-07-21 1980-04-30 The Massachusetts General Hospital Isoquinoline derivatives, their preparation and pharmaceutical compositions containing these compounds
US4235906A (en) 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
EP0054309A1 (en) * 1980-12-17 1982-06-23 The Wellcome Foundation Limited Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
US4761418A (en) * 1984-07-18 1988-08-02 Burroughs Wellcome Co. Novel compounds

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010119A1 (en) * 1978-07-21 1980-04-30 The Massachusetts General Hospital Isoquinoline derivatives, their preparation and pharmaceutical compositions containing these compounds
US4235906A (en) 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
EP0054309A1 (en) * 1980-12-17 1982-06-23 The Wellcome Foundation Limited Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
US4761418A (en) * 1984-07-18 1988-08-02 Burroughs Wellcome Co. Novel compounds

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