GB863717A - Tetrahydropapaverine derivatives and their preparation - Google Patents
Tetrahydropapaverine derivatives and their preparationInfo
- Publication number
- GB863717A GB863717A GB2139558A GB2139558A GB863717A GB 863717 A GB863717 A GB 863717A GB 2139558 A GB2139558 A GB 2139558A GB 2139558 A GB2139558 A GB 2139558A GB 863717 A GB863717 A GB 863717A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tetrahydropapaverine
- preparation
- alkyl
- bromalkyl
- dicarboxylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
The invention comprises compounds of the formula: <FORM:0863717/IV (b)/1> wherein R is alkyl of less than 7 carbon atoms, X is an anion, m is 2 or 3, and n is 0, 1, 2, 3 or 4, and processes for their preparation: (a) by refluxing an excess of an N-alkyl-tetrahydropapaverine with an o -bromalkyl dicarboxylate in an inert solvent for a prolonged period giving compounds of the above formula in which X is bromine; and (b) by reacting an o -bromalkyl dicarboxylate with tetrahydropapaverine in the presence of an acid-binding agent and treating the product with at least two molecular proportions of an alkyl halide or alkyl sulphate. Examples detail the preparation of thirteen dibromide, di-iodide, diperchlorate and dinitrate salts of the above formula.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2139558A GB863717A (en) | 1958-07-03 | 1958-07-03 | Tetrahydropapaverine derivatives and their preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2139558A GB863717A (en) | 1958-07-03 | 1958-07-03 | Tetrahydropapaverine derivatives and their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
GB863717A true GB863717A (en) | 1961-03-22 |
Family
ID=10162200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2139558A Expired GB863717A (en) | 1958-07-03 | 1958-07-03 | Tetrahydropapaverine derivatives and their preparation |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB863717A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0010119A1 (en) * | 1978-07-21 | 1980-04-30 | The Massachusetts General Hospital | Isoquinoline derivatives, their preparation and pharmaceutical compositions containing these compounds |
US4235906A (en) | 1978-07-21 | 1980-11-25 | Massachusetts General Hospital | Bis-isoquinolinium compounds, compositions and methods of use |
EP0054309A1 (en) * | 1980-12-17 | 1982-06-23 | The Wellcome Foundation Limited | Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation |
US4701460A (en) * | 1980-12-17 | 1987-10-20 | Burroughs Wellcome Co. | Long duration neuromuscular blocking agents |
US4761418A (en) * | 1984-07-18 | 1988-08-02 | Burroughs Wellcome Co. | Novel compounds |
-
1958
- 1958-07-03 GB GB2139558A patent/GB863717A/en not_active Expired
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0010119A1 (en) * | 1978-07-21 | 1980-04-30 | The Massachusetts General Hospital | Isoquinoline derivatives, their preparation and pharmaceutical compositions containing these compounds |
US4235906A (en) | 1978-07-21 | 1980-11-25 | Massachusetts General Hospital | Bis-isoquinolinium compounds, compositions and methods of use |
EP0054309A1 (en) * | 1980-12-17 | 1982-06-23 | The Wellcome Foundation Limited | Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation |
US4701460A (en) * | 1980-12-17 | 1987-10-20 | Burroughs Wellcome Co. | Long duration neuromuscular blocking agents |
US4761418A (en) * | 1984-07-18 | 1988-08-02 | Burroughs Wellcome Co. | Novel compounds |
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