ES8609260A1 - Un procedimiento para preparar derivados de trimetoxibencil-isoquinolinio - Google Patents

Un procedimiento para preparar derivados de trimetoxibencil-isoquinolinio

Info

Publication number
ES8609260A1
ES8609260A1 ES545319A ES545319A ES8609260A1 ES 8609260 A1 ES8609260 A1 ES 8609260A1 ES 545319 A ES545319 A ES 545319A ES 545319 A ES545319 A ES 545319A ES 8609260 A1 ES8609260 A1 ES 8609260A1
Authority
ES
Spain
Prior art keywords
trimethoxybenzyl
dimethoxymethyl
bis
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545319A
Other languages
English (en)
Other versions
ES545319A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
General Hospital Corp
Original Assignee
Wellcome Foundation Ltd
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd, General Hospital Corp filed Critical Wellcome Foundation Ltd
Publication of ES8609260A1 publication Critical patent/ES8609260A1/es
Publication of ES545319A0 publication Critical patent/ES545319A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Jib Cranes (AREA)
  • Fats And Perfumes (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Cephalosporin Compounds (AREA)
  • Cosmetics (AREA)

Abstract

DERIVADOS DE TRIMETOXIBENCIL-ISOQUINOLINIO, COMPOSICIONES FARMACEUTICAS QUE LAS CONTIENEN Y PROCEDIMIENTO PARA SU PREPARACION. SE COPULA UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), A UNA TEMPERATURA COMPRENDIDA ENTRE LA DEL AMBIENTE Y LA DE EBULLICION DE LA MEZCLA DE REACCION, EN PRESENCIA DE UN EXCESO DE DISOLVENTE ORGANICO HALOGENADO, PARA DAR UN COMPUESTO DE FORMULA (I). SON AGENTES DE BLANQUEO NEUROMUSCULAR DE DURACION RELATIVAMENTE CORTA, UTILIZABLES COMO RELAJANTES MUSCULARES DEL ESQUELETO EN LAS OPERACIONES QUIRURGICAS.
ES545319A 1984-07-18 1985-07-17 Un procedimiento para preparar derivados de trimetoxibencil-isoquinolinio Expired ES8609260A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848418303A GB8418303D0 (en) 1984-07-18 1984-07-18 Compounds

Publications (2)

Publication Number Publication Date
ES8609260A1 true ES8609260A1 (es) 1986-09-01
ES545319A0 ES545319A0 (es) 1986-09-01

Family

ID=10564058

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545319A Expired ES8609260A1 (es) 1984-07-18 1985-07-17 Un procedimiento para preparar derivados de trimetoxibencil-isoquinolinio

Country Status (30)

Country Link
US (1) US4761418A (es)
EP (1) EP0181055B1 (es)
JP (1) JPH0662568B2 (es)
AT (1) ATE60759T1 (es)
AU (1) AU574481B2 (es)
BG (1) BG60411B2 (es)
CA (1) CA1273341A (es)
CY (1) CY1687A (es)
DD (1) DD235638A5 (es)
DE (2) DE3581699D1 (es)
DK (1) DK168093B1 (es)
ES (1) ES8609260A1 (es)
FI (1) FI85019C (es)
GB (1) GB8418303D0 (es)
GE (1) GEP19960468B (es)
HK (1) HK47593A (es)
HU (1) HU193996B (es)
IE (1) IE58138B1 (es)
IL (1) IL75833A (es)
LT (1) LT2078B (es)
LU (1) LU88801I2 (es)
LV (1) LV5483A3 (es)
MC (1) MC1690A1 (es)
MX (1) MX9203667A (es)
NL (1) NL940023I2 (es)
NZ (1) NZ212766A (es)
PL (1) PL146066B1 (es)
SG (1) SG3493G (es)
SU (1) SU1468414A3 (es)
ZA (1) ZA855407B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
WO1998042674A1 (en) * 1997-03-25 1998-10-01 Glaxo Group Limited Substituted isoquinolines as ultra short acting neuromuscular blockers
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
WO2005041960A2 (en) * 2003-10-28 2005-05-12 Cornell Research Foundation, Inc. Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) * 2006-06-20 2011-01-18 Farmabios S.P.A. Process for the preparation of mivacurium chloride
AU2007328210B2 (en) * 2006-12-06 2012-11-22 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
CA2680277A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
US20100087650A1 (en) * 2007-03-26 2010-04-08 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
CA2685488A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
BRPI0809893A2 (pt) * 2007-05-01 2014-09-30 Chemagis Ltd Processo para prepar um sal de (1r-cis) - [(3,4 - dimetoxifenil) metil] - 1, 2,3,4 - tetraidro - 6,7 - dimetoxi - 2 - metil - 2 - carboxietil - isoquinolínio"
CA2687157A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
BRPI0812625A2 (pt) * 2007-07-09 2019-02-19 Chemagis Ltd processo para preparar um sal de cis-atracúrio
WO2009057086A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
ITMI20080319A1 (it) 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
WO2009133556A2 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
WO2010107488A1 (en) 2009-03-17 2010-09-23 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
CN102573794B (zh) 2009-08-19 2017-03-15 康奈尔大学 供生理注射用的半胱氨酸
WO2013021398A2 (en) * 2011-08-05 2013-02-14 Sequent Scientific Limited A process for preparation of mivacurium chloride
EP2867219B1 (en) 2012-06-29 2017-02-15 Cornell University Asymmetrical reversible neuromuscular blocking agents of ultra-short, short, or intermediate duration
CN103373959A (zh) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 顺式苄基异喹啉类化合物的制备方法及其用途
CN107778237A (zh) * 2016-08-26 2018-03-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN107782821B (zh) * 2016-08-26 2021-11-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂的分析方法
CN108938573B (zh) * 2017-05-26 2021-08-10 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) * 2017-09-30 2018-09-07 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) * 2019-07-29 2022-04-29 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) * 2019-11-11 2021-03-09 武汉大安制药有限公司 一种5’-甲氧基劳丹素的拆分方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB863717A (en) * 1958-07-03 1961-03-22 Allen & Hanburys Ltd Tetrahydropapaverine derivatives and their preparation
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
US4192877A (en) * 1977-08-01 1980-03-11 Massachusetts General Hospital Neuromuscular blocking agents
ZA784331B (en) * 1977-08-01 1979-12-27 Massachusetts Gen Hospital Neuromuscular blocking agents
US4235906A (en) * 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
CA1153380A (en) * 1979-10-19 1983-09-06 Hassan A. El-Sayad Neuromuscular blocking tetrahydroisoquinolinium salts
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
DE3165714D1 (en) * 1980-12-17 1984-09-27 Wellcome Found Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) * 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体

Also Published As

Publication number Publication date
LT2078B (lt) 1993-06-15
EP0181055B1 (en) 1991-02-06
AU4510885A (en) 1986-01-23
NZ212766A (en) 1988-03-30
DE19675039I2 (de) 2003-01-09
MC1690A1 (fr) 1986-07-18
JPH0662568B2 (ja) 1994-08-17
FI85019B (fi) 1991-11-15
IE851791L (en) 1986-01-18
IL75833A0 (en) 1985-11-29
DK168093B1 (da) 1994-02-07
DE3581699D1 (de) 1991-03-14
PL146066B1 (en) 1988-12-31
HK47593A (en) 1993-05-21
SU1468414A3 (ru) 1989-03-23
DK324985D0 (da) 1985-07-17
JPS6187666A (ja) 1986-05-06
HU193996B (en) 1987-12-28
HUT40626A (en) 1987-01-28
ZA855407B (en) 1986-04-30
SG3493G (en) 1993-03-12
LU88801I2 (fr) 1996-11-05
AU574481B2 (en) 1988-07-07
EP0181055A1 (en) 1986-05-14
FI85019C (fi) 1992-02-25
NL940023I1 (nl) 1995-01-02
DD235638A5 (de) 1986-05-14
IE58138B1 (en) 1993-07-14
US4761418A (en) 1988-08-02
MX9203667A (es) 1992-07-31
LV5483A3 (lv) 1994-03-10
ATE60759T1 (de) 1991-02-15
CY1687A (en) 1993-10-10
PL254571A1 (en) 1986-07-15
BG60411B2 (bg) 1995-02-28
NL940023I2 (nl) 1998-06-02
FI852807L (fi) 1986-01-19
GEP19960468B (en) 1996-08-29
IL75833A (en) 1988-11-30
CA1273341A (en) 1990-08-28
FI852807A0 (fi) 1985-07-17
GB8418303D0 (en) 1984-08-22
ES545319A0 (es) 1986-09-01
DK324985A (da) 1986-01-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060530