NL940023I2 - Bis-dimethoxymethyl(trimethoxybenzyl-) isochinoliniumzouten, hun bereiding en deze bevattende farmaceutische preparaten. - Google Patents

Bis-dimethoxymethyl(trimethoxybenzyl-) isochinoliniumzouten, hun bereiding en deze bevattende farmaceutische preparaten.

Info

Publication number
NL940023I2
NL940023I2 NL940023C NL940023C NL940023I2 NL 940023 I2 NL940023 I2 NL 940023I2 NL 940023 C NL940023 C NL 940023C NL 940023 C NL940023 C NL 940023C NL 940023 I2 NL940023 I2 NL 940023I2
Authority
NL
Netherlands
Prior art keywords
trimethoxybenzyl
dimethoxymethyl
bis
preparation
pharmaceutical preparations
Prior art date
Application number
NL940023C
Other languages
English (en)
Other versions
NL940023I1 (nl
Original Assignee
Wellcome Found
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found, Gen Hospital Corp filed Critical Wellcome Found
Publication of NL940023I1 publication Critical patent/NL940023I1/nl
Publication of NL940023I2 publication Critical patent/NL940023I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Jib Cranes (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Medicinal Preparation (AREA)
  • Fats And Perfumes (AREA)
  • Cephalosporin Compounds (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Cosmetics (AREA)
NL940023C 1984-07-18 1994-11-18 Bis-dimethoxymethyl(trimethoxybenzyl-) isochinoliniumzouten, hun bereiding en deze bevattende farmaceutische preparaten. NL940023I2 (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848418303A GB8418303D0 (en) 1984-07-18 1984-07-18 Compounds

Publications (2)

Publication Number Publication Date
NL940023I1 NL940023I1 (nl) 1995-01-02
NL940023I2 true NL940023I2 (nl) 1998-06-02

Family

ID=10564058

Family Applications (1)

Application Number Title Priority Date Filing Date
NL940023C NL940023I2 (nl) 1984-07-18 1994-11-18 Bis-dimethoxymethyl(trimethoxybenzyl-) isochinoliniumzouten, hun bereiding en deze bevattende farmaceutische preparaten.

Country Status (30)

Country Link
US (1) US4761418A (nl)
EP (1) EP0181055B1 (nl)
JP (1) JPH0662568B2 (nl)
AT (1) ATE60759T1 (nl)
AU (1) AU574481B2 (nl)
BG (1) BG60411B2 (nl)
CA (1) CA1273341A (nl)
CY (1) CY1687A (nl)
DD (1) DD235638A5 (nl)
DE (2) DE19675039I2 (nl)
DK (1) DK168093B1 (nl)
ES (1) ES8609260A1 (nl)
FI (1) FI85019C (nl)
GB (1) GB8418303D0 (nl)
GE (1) GEP19960468B (nl)
HK (1) HK47593A (nl)
HU (1) HU193996B (nl)
IE (1) IE58138B1 (nl)
IL (1) IL75833A (nl)
LT (1) LT2078B (nl)
LU (1) LU88801I2 (nl)
LV (1) LV5483A3 (nl)
MC (1) MC1690A1 (nl)
MX (1) MX9203667A (nl)
NL (1) NL940023I2 (nl)
NZ (1) NZ212766A (nl)
PL (1) PL146066B1 (nl)
SG (1) SG3493G (nl)
SU (1) SU1468414A3 (nl)
ZA (1) ZA855407B (nl)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
AU745382B2 (en) * 1997-03-25 2002-03-21 Cornell Research Foundation Inc. Substituted isoquinolines as ultra short acting neuromuscular blockers
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
EP1684753A2 (en) * 2003-10-28 2006-08-02 Cornell Research Foundation, Inc. Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) * 2006-06-20 2011-01-18 Farmabios S.P.A. Process for the preparation of mivacurium chloride
ATE554769T1 (de) * 2006-12-06 2012-05-15 Cornell Res Foundation Inc Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
US8461338B2 (en) * 2007-03-08 2013-06-11 Chemagis Ltd. (1R, 1′R)-atracurium salts separation process
AU2008231470A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
CA2685491A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
WO2009007946A1 (en) * 2007-07-09 2009-01-15 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
US8357807B2 (en) * 2007-05-01 2013-01-22 Chemagis Ltd. Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
US8357805B2 (en) * 2007-06-18 2013-01-22 Chemagis Ltd. (1R,1′R)-atracurium salts separation process
WO2009057086A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
ITMI20080319A1 (it) * 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
US20110185796A1 (en) * 2008-05-01 2011-08-04 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
WO2011022491A1 (en) 2009-08-19 2011-02-24 Cornell University Cysteine for physiological injection
WO2013021398A2 (en) * 2011-08-05 2013-02-14 Sequent Scientific Limited A process for preparation of mivacurium chloride
JP6236077B2 (ja) 2012-06-29 2017-11-22 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ 持続時間が超短期、短期、または中期の非対称性逆転可能神経筋遮断物質
CN103373959A (zh) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 顺式苄基异喹啉类化合物的制备方法及其用途
CN107782821B (zh) * 2016-08-26 2021-11-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂的分析方法
CN107778237A (zh) * 2016-08-26 2018-03-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN108938573B (zh) * 2017-05-26 2021-08-10 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) * 2017-09-30 2018-09-07 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) * 2019-07-29 2022-04-29 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) * 2019-11-11 2021-03-09 武汉大安制药有限公司 一种5’-甲氧基劳丹素的拆分方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB863717A (en) * 1958-07-03 1961-03-22 Allen & Hanburys Ltd Tetrahydropapaverine derivatives and their preparation
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
BE869415A (fr) * 1977-08-01 1979-01-31 Massachusetts Gen Hospital Agents de blocage neuromusculaire
US4192877A (en) * 1977-08-01 1980-03-11 Massachusetts General Hospital Neuromuscular blocking agents
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4235906A (en) * 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
CA1153380A (en) * 1979-10-19 1983-09-06 Hassan A. El-Sayad Neuromuscular blocking tetrahydroisoquinolinium salts
CA1178275A (en) * 1980-12-17 1984-11-20 David A. Yeowell Bis-isoquinolinium salts as long duration neuromuscular blocking agents
JPS5899465A (ja) * 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体

Also Published As

Publication number Publication date
ZA855407B (en) 1986-04-30
ES8609260A1 (es) 1986-09-01
FI852807L (fi) 1986-01-19
CA1273341A (en) 1990-08-28
LU88801I2 (fr) 1996-11-05
HK47593A (en) 1993-05-21
LV5483A3 (lv) 1994-03-10
AU4510885A (en) 1986-01-23
JPS6187666A (ja) 1986-05-06
DK324985D0 (da) 1985-07-17
DK168093B1 (da) 1994-02-07
DE3581699D1 (de) 1991-03-14
GEP19960468B (en) 1996-08-29
LT2078B (lt) 1993-06-15
JPH0662568B2 (ja) 1994-08-17
DD235638A5 (de) 1986-05-14
SG3493G (en) 1993-03-12
IE851791L (en) 1986-01-18
DE19675039I2 (de) 2003-01-09
DK324985A (da) 1986-01-19
BG60411B2 (bg) 1995-02-28
PL146066B1 (en) 1988-12-31
GB8418303D0 (en) 1984-08-22
ES545319A0 (es) 1986-09-01
IL75833A (en) 1988-11-30
IL75833A0 (en) 1985-11-29
FI852807A0 (fi) 1985-07-17
CY1687A (en) 1993-10-10
NL940023I1 (nl) 1995-01-02
IE58138B1 (en) 1993-07-14
HU193996B (en) 1987-12-28
SU1468414A3 (ru) 1989-03-23
US4761418A (en) 1988-08-02
MX9203667A (es) 1992-07-31
ATE60759T1 (de) 1991-02-15
NZ212766A (en) 1988-03-30
EP0181055A1 (en) 1986-05-14
HUT40626A (en) 1987-01-28
FI85019C (fi) 1992-02-25
AU574481B2 (en) 1988-07-07
FI85019B (fi) 1991-11-15
PL254571A1 (en) 1986-07-15
MC1690A1 (fr) 1986-07-18
EP0181055B1 (en) 1991-02-06

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