ATE554769T1 - Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon - Google Patents
Neuromuskuläre blocker mit mittlerer dauer und antagonisten advonInfo
- Publication number
- ATE554769T1 ATE554769T1 AT07862551T AT07862551T ATE554769T1 AT E554769 T1 ATE554769 T1 AT E554769T1 AT 07862551 T AT07862551 T AT 07862551T AT 07862551 T AT07862551 T AT 07862551T AT E554769 T1 ATE554769 T1 AT E554769T1
- Authority
- AT
- Austria
- Prior art keywords
- advon
- antagonists
- medium
- neuromuscular blockers
- during neuromuscular
- Prior art date
Links
- 239000000842 neuromuscular blocking agent Substances 0.000 title abstract 4
- 239000005557 antagonist Substances 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87313206P | 2006-12-06 | 2006-12-06 | |
PCT/US2007/024914 WO2008070121A1 (en) | 2006-12-06 | 2007-12-05 | Intermediate duration neuromuscular blocking agents and antagonists thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE554769T1 true ATE554769T1 (de) | 2012-05-15 |
Family
ID=39492558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07862551T ATE554769T1 (de) | 2006-12-06 | 2007-12-05 | Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon |
Country Status (8)
Country | Link |
---|---|
US (1) | US8148398B2 (de) |
EP (1) | EP2101772B1 (de) |
JP (1) | JP5213137B2 (de) |
CN (1) | CN101588803B (de) |
AT (1) | ATE554769T1 (de) |
AU (1) | AU2007328210B2 (de) |
CA (1) | CA2671904C (de) |
WO (1) | WO2008070121A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007328210B2 (en) | 2006-12-06 | 2012-11-22 | Cornell Research Foundation, Inc. | Intermediate duration neuromuscular blocking agents and antagonists thereof |
BRPI0808272A2 (pt) * | 2007-03-08 | 2014-07-08 | Chemagis Ltd | "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio" |
BRPI0808581A2 (pt) * | 2007-03-26 | 2014-09-16 | Chemagis Ltd | "método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio" |
CA2685491A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
CA2685488A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
BRPI0811687A2 (pt) * | 2007-06-18 | 2015-02-18 | Chemagis Ltd | MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO |
EP2176227A1 (de) * | 2007-07-09 | 2010-04-21 | Chemagis Ltd. | Verfahren zur herstellung von cisatracurium und zugehörige zwischenprodukte |
BRPI0816519A2 (pt) * | 2007-10-29 | 2015-03-24 | Chemagis Ltd | Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio |
WO2009133556A2 (en) * | 2008-05-01 | 2009-11-05 | Chemagis Ltd. | Cisatracurium derivatives, preparation and uses thereof |
WO2010107488A1 (en) * | 2009-03-17 | 2010-09-23 | Cornell University | Reversible nondepolarizing neuromuscular blockade agents and methods for their use |
WO2011022491A1 (en) * | 2009-08-19 | 2011-02-24 | Cornell University | Cysteine for physiological injection |
ES2625329T3 (es) | 2012-06-29 | 2017-07-19 | Cornell University | Agentes bloqueantes neuromusculares asimétricos reversibles de duración ultra-corta, corta o intermedia |
WO2014210369A2 (en) * | 2013-06-28 | 2014-12-31 | Cornell University | Reversal of cysteine-inactivated neuromuscular blocking drugs with combinations of reversal agents |
CN108375644B (zh) * | 2016-12-07 | 2021-11-30 | 四川科瑞德制药股份有限公司 | 一种神经肌肉阻滞剂中间体的分析方法 |
CN110776481B (zh) | 2018-07-24 | 2023-06-16 | 四川大学华西医院 | 一类双阳离子化合物及其制备方法和用途 |
CN108727248B (zh) | 2018-07-25 | 2021-05-25 | 四川大学华西医院 | 一类双季铵化合物及其制备方法和用途 |
WO2021115413A1 (zh) * | 2019-12-11 | 2021-06-17 | 江苏恒瑞医药股份有限公司 | 神经肌肉阻滞剂及其制备方法 |
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US3004031A (en) | 1958-07-03 | 1961-10-10 | Allen & Hauburys Ltd | Diquaternary salts of papaverino esters |
US4036959A (en) | 1974-10-29 | 1977-07-19 | Millmaster Onyx Corporation | Microbiocidal capped polymers |
AU506657B2 (en) | 1975-12-10 | 1980-01-17 | Wellcome Foundation Limited, The | Isoquinoline derivatives |
US4039682A (en) * | 1976-03-29 | 1977-08-02 | Baxter Travenol Laboratories, Inc. | Method and composition for relief of back pain |
US4192877A (en) * | 1977-08-01 | 1980-03-11 | Massachusetts General Hospital | Neuromuscular blocking agents |
BE869415A (fr) * | 1977-08-01 | 1979-01-31 | Massachusetts Gen Hospital | Agents de blocage neuromusculaire |
US4235906A (en) | 1978-07-21 | 1980-11-25 | Massachusetts General Hospital | Bis-isoquinolinium compounds, compositions and methods of use |
EP0008824B1 (de) | 1978-09-05 | 1982-04-28 | Akzo N.V. | Säureadditionssalze von 2-beta, 16-beta-bis-Piperidino-androstan-16-beta-monoquaternären Ammoniumderivaten und diese enthaltende pharmazeutische Zusammensetzungen |
US4491665A (en) | 1979-10-19 | 1985-01-01 | Burroughs Wellcome Co. | Method of preparing isomers of bis isoquinolinium compounds |
US4727146A (en) | 1980-07-03 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction |
US4556712A (en) | 1981-05-20 | 1985-12-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines |
US4701460A (en) | 1980-12-17 | 1987-10-20 | Burroughs Wellcome Co. | Long duration neuromuscular blocking agents |
US4656174A (en) | 1982-07-24 | 1987-04-07 | Pfizer Inc. | Quinoline therapeutic agents |
BG38182A1 (en) | 1983-06-21 | 1985-11-15 | Ivanova | Tocolytic means |
GB8418303D0 (en) * | 1984-07-18 | 1984-08-22 | Wellcome Found | Compounds |
DE3436179A1 (de) | 1984-10-03 | 1986-04-10 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren zur herstellung optisch aktiver amine |
GB8518634D0 (en) | 1985-07-23 | 1985-08-29 | Smithkline Beckman Corp | Chemical compounds |
US5453510A (en) | 1990-07-13 | 1995-09-26 | Burroughs Wellcome Co. | Neuromuscular blocking agents |
DE4135710A1 (de) | 1991-10-30 | 1993-05-06 | Basf Ag, 6700 Ludwigshafen, De | Cyclische ammoniumverbindungen und ihre verwendung als glanzmittel fuer waessrig-saure galvanische nickelbaeder |
US5240939A (en) | 1991-10-31 | 1993-08-31 | Anaquest, Inc. | Nitrogen bridge tetrahydroisoquinolines |
US5739170A (en) | 1992-09-11 | 1998-04-14 | The Regents Of The University Of California | Inhibitors of metazoan parasite proteases |
US5684154A (en) | 1996-02-16 | 1997-11-04 | Abbott Laboratories | Process for the preparation and isolation of atracurium besylate |
ES2210757T3 (es) | 1997-03-25 | 2004-07-01 | Avera Pharmaceuticals, Inc. | Isoquinolinas sustituidas como bloqueadores neuromusculares de accion ultracorta. |
EP0971743B1 (de) * | 1997-04-18 | 2006-07-12 | Fritz Stanislaus | Stabilisiertes arzneimittel enthaltend cysteinylderivate |
US7897598B2 (en) | 1998-06-09 | 2011-03-01 | Alexandros Makriyannis | Inhibitors of the anandamide transporter |
US6562836B1 (en) | 1999-05-24 | 2003-05-13 | Queen's University Of Kingston | Methods and compounds for inhibiting amyloid deposits |
WO2001045697A1 (fr) | 1999-12-21 | 2001-06-28 | Kanebo, Limited | Agents et medicaments a usage cutane externe |
DE10000577A1 (de) | 2000-01-10 | 2001-07-26 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten |
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JPWO2002051836A1 (ja) | 2000-12-27 | 2004-04-22 | 協和醗酵工業株式会社 | ジペプチジルペプチダーゼ−iv阻害剤 |
DE10101307A1 (de) | 2001-01-12 | 2002-08-01 | Fumapharm Ag Muri | Fumarsäurederivate als NF-kappaB-Inhibitor |
JP2004523511A (ja) | 2001-01-12 | 2004-08-05 | フーマファーム アーゲー | フマル酸アミド類 |
TWI320039B (en) | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
JP4463206B2 (ja) * | 2003-08-12 | 2010-05-19 | 日本臓器製薬株式会社 | グリチルリチン高濃度製剤 |
EP1684753A2 (de) | 2003-10-28 | 2006-08-02 | Cornell Research Foundation, Inc. | Neuromuskuläre blockiermittel und ihre antagonisten |
ES2763724T3 (es) * | 2005-12-27 | 2020-05-29 | Univ Ramot | Preparaciones enzimáticas estables y métodos de uso de las mismas |
AU2007328210B2 (en) | 2006-12-06 | 2012-11-22 | Cornell Research Foundation, Inc. | Intermediate duration neuromuscular blocking agents and antagonists thereof |
WO2010107488A1 (en) * | 2009-03-17 | 2010-09-23 | Cornell University | Reversible nondepolarizing neuromuscular blockade agents and methods for their use |
WO2011022491A1 (en) * | 2009-08-19 | 2011-02-24 | Cornell University | Cysteine for physiological injection |
-
2007
- 2007-12-05 AU AU2007328210A patent/AU2007328210B2/en active Active
- 2007-12-05 CA CA2671904A patent/CA2671904C/en active Active
- 2007-12-05 EP EP07862551A patent/EP2101772B1/de active Active
- 2007-12-05 JP JP2009540280A patent/JP5213137B2/ja active Active
- 2007-12-05 AT AT07862551T patent/ATE554769T1/de active
- 2007-12-05 US US11/951,114 patent/US8148398B2/en active Active
- 2007-12-05 WO PCT/US2007/024914 patent/WO2008070121A1/en active Application Filing
- 2007-12-05 CN CN2007800505324A patent/CN101588803B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
EP2101772A1 (de) | 2009-09-23 |
CN101588803B (zh) | 2013-03-20 |
AU2007328210A1 (en) | 2008-06-12 |
EP2101772B1 (de) | 2012-04-25 |
WO2008070121A1 (en) | 2008-06-12 |
AU2007328210B2 (en) | 2012-11-22 |
JP2010511715A (ja) | 2010-04-15 |
US20080139482A1 (en) | 2008-06-12 |
CA2671904C (en) | 2012-07-03 |
JP5213137B2 (ja) | 2013-06-19 |
CN101588803A (zh) | 2009-11-25 |
US8148398B2 (en) | 2012-04-03 |
CA2671904A1 (en) | 2008-06-12 |
AU2007328210A2 (en) | 2011-06-09 |
EP2101772A4 (de) | 2010-12-01 |
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