BRPI0816519A2 - Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio - Google Patents
Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrioInfo
- Publication number
- BRPI0816519A2 BRPI0816519A2 BRPI0816519A BRPI0816519A2 BR PI0816519 A2 BRPI0816519 A2 BR PI0816519A2 BR PI0816519 A BRPI0816519 A BR PI0816519A BR PI0816519 A2 BRPI0816519 A2 BR PI0816519A2
- Authority
- BR
- Brazil
- Prior art keywords
- atracurium salt
- preparing
- atracurium
- salt
- isomerically enriched
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98344007P | 2007-10-29 | 2007-10-29 | |
PCT/IL2008/001329 WO2009057086A1 (en) | 2007-10-29 | 2008-10-07 | Novel r,r'-atracurium salts |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0816519A2 true BRPI0816519A2 (pt) | 2015-03-24 |
Family
ID=40259082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0816519 BRPI0816519A2 (pt) | 2007-10-29 | 2008-10-07 | Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio |
Country Status (6)
Country | Link |
---|---|
US (1) | US8354537B2 (pt) |
EP (1) | EP2197848A1 (pt) |
AU (1) | AU2008320380A1 (pt) |
BR (1) | BRPI0816519A2 (pt) |
CA (1) | CA2702535A1 (pt) |
WO (1) | WO2009057086A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0808272A2 (pt) * | 2007-03-08 | 2014-07-08 | Chemagis Ltd | "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio" |
BRPI0808581A2 (pt) * | 2007-03-26 | 2014-09-16 | Chemagis Ltd | "método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio" |
WO2008132748A1 (en) | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
CA2685488A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
WO2009007946A1 (en) * | 2007-07-09 | 2009-01-15 | Chemagis Ltd. | Process for producing cisatracurium and associated intermediates |
WO2008155752A1 (en) * | 2007-06-18 | 2008-12-24 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
CA2722651A1 (en) * | 2008-05-01 | 2009-11-05 | Chemagis Ltd. | Cisatracurium derivatives, preparation and uses thereof |
CN104292161B (zh) * | 2014-09-19 | 2016-06-22 | 大道隆达(北京)医药科技发展有限公司 | 一种顺苯磺阿曲库铵的精制方法 |
CN113045493B (zh) * | 2020-06-22 | 2022-04-01 | 连云港贵科药业有限公司 | 一种顺苯磺阿曲库铵的提纯方法 |
CN114014806A (zh) * | 2021-12-03 | 2022-02-08 | 江苏诚信药业有限公司 | 一种新晶型顺苯磺酸阿曲库铵及其结晶方法 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU506657B2 (en) * | 1975-12-10 | 1980-01-17 | Wellcome Foundation Limited, The | Isoquinoline derivatives |
US4491665A (en) * | 1979-10-19 | 1985-01-01 | Burroughs Wellcome Co. | Method of preparing isomers of bis isoquinolinium compounds |
US4701460A (en) * | 1980-12-17 | 1987-10-20 | Burroughs Wellcome Co. | Long duration neuromuscular blocking agents |
GB8418303D0 (en) * | 1984-07-18 | 1984-08-22 | Wellcome Found | Compounds |
BG41897A1 (en) * | 1985-07-19 | 1987-09-15 | Ivanov | Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation |
JPS62265266A (ja) * | 1986-05-13 | 1987-11-18 | Takasago Corp | N−アシル−テトラヒドロイソキノリン類の製造法 |
US4988815A (en) * | 1989-10-26 | 1991-01-29 | Riker Laboratories, Inc. | 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines |
GB9015473D0 (en) | 1990-07-13 | 1990-08-29 | Wellcome Found | Neuromuscular blocking agents |
US5453510A (en) * | 1990-07-13 | 1995-09-26 | Burroughs Wellcome Co. | Neuromuscular blocking agents |
US5240939A (en) * | 1991-10-31 | 1993-08-31 | Anaquest, Inc. | Nitrogen bridge tetrahydroisoquinolines |
DE19535762A1 (de) * | 1995-09-26 | 1997-03-27 | Basf Ag | Verfahren zur Racematspaltung |
US5684154A (en) * | 1996-02-16 | 1997-11-04 | Abbott Laboratories | Process for the preparation and isolation of atracurium besylate |
EP1526130A1 (en) | 1997-03-25 | 2005-04-27 | Avera Pharmaceuticals, Inc. | Substituted isoquinolines as ultra short acting neuromuscular blockers |
EP1210090B1 (en) * | 1999-08-13 | 2014-06-18 | Merck Sharp & Dohme B.V. | Use of chemical chelators as reversal agents for drug-induced neuromuscular block |
EP1346214A2 (en) * | 2000-12-29 | 2003-09-24 | Pfizer Limited | Reference standards and processes for determining the purity or stability of amlodipine maleate |
US20060009485A1 (en) * | 2005-06-23 | 2006-01-12 | Chemagis Ltd | Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents |
WO2007059019A2 (en) * | 2005-11-14 | 2007-05-24 | Winch Peter D | Novel colored solutions of injectable drugs and their pharmaceutically acceptable salts |
KR20070080108A (ko) | 2006-02-06 | 2007-08-09 | 주식회사종근당 | 질소의 알파 위치에 비대칭탄소가 있는 라세믹 유도체의광학 이성질체 분리 방법 |
US8148398B2 (en) * | 2006-12-06 | 2012-04-03 | Cornell Research Foundation, Inc. | Intermediate duration neuromuscular blocking agents and antagonists thereof |
BRPI0808272A2 (pt) | 2007-03-08 | 2014-07-08 | Chemagis Ltd | "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio" |
CN100531734C (zh) | 2007-03-13 | 2009-08-26 | 黄乐群 | 阿曲库铵冷冻干燥组合物 |
BRPI0808581A2 (pt) * | 2007-03-26 | 2014-09-16 | Chemagis Ltd | "método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio" |
WO2008132748A1 (en) | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
WO2009007946A1 (en) | 2007-07-09 | 2009-01-15 | Chemagis Ltd. | Process for producing cisatracurium and associated intermediates |
CA2685488A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
WO2008155752A1 (en) | 2007-06-18 | 2008-12-24 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
CN101337935B (zh) | 2007-07-06 | 2011-01-12 | 江苏恒瑞医药股份有限公司 | 一种用两相萃取法纯化苯磺酸阿曲库铵的方法 |
CN101337936B (zh) | 2007-07-06 | 2011-03-23 | 江苏恒瑞医药股份有限公司 | 一种用柱色谱法纯化苯磺酸阿曲库铵的方法 |
ITMI20080319A1 (it) * | 2008-02-28 | 2009-08-29 | Recordati Chem Pharm | Processo per la risoluzione di derivati isochinolinici |
CA2722651A1 (en) * | 2008-05-01 | 2009-11-05 | Chemagis Ltd. | Cisatracurium derivatives, preparation and uses thereof |
IT1396543B1 (it) * | 2008-07-16 | 2012-12-14 | Farmabios Spa | Processo per la purificazione di bloccanti neuromuscolari |
CN101475530A (zh) | 2009-01-16 | 2009-07-08 | 东英(江苏)药业有限公司 | 通过制备液相色谱法分离纯化顺苯磺酸阿曲库铵的方法 |
CN101845017A (zh) | 2009-03-24 | 2010-09-29 | 天津市炜杰科技有限公司 | 苯磺酸阿曲库铵类中间体的制备方法 |
WO2010128519A1 (en) | 2009-05-04 | 2010-11-11 | Kumar C Jairaj | A method for detecting neuropathy and predicting foot ulcer development in human beings with health conditions like diabetes mellitus |
WO2010128518A2 (en) | 2009-05-04 | 2010-11-11 | Gland Pharma Limited | Novel process for the preparation of cisatracurium besylate |
-
2008
- 2008-10-07 EP EP08844602A patent/EP2197848A1/en not_active Withdrawn
- 2008-10-07 US US12/739,789 patent/US8354537B2/en not_active Expired - Fee Related
- 2008-10-07 BR BRPI0816519 patent/BRPI0816519A2/pt not_active IP Right Cessation
- 2008-10-07 CA CA2702535A patent/CA2702535A1/en not_active Abandoned
- 2008-10-07 AU AU2008320380A patent/AU2008320380A1/en not_active Abandoned
- 2008-10-07 WO PCT/IL2008/001329 patent/WO2009057086A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
AU2008320380A1 (en) | 2009-05-07 |
WO2009057086A1 (en) | 2009-05-07 |
US8354537B2 (en) | 2013-01-15 |
US20100234602A1 (en) | 2010-09-16 |
CA2702535A1 (en) | 2009-05-07 |
EP2197848A1 (en) | 2010-06-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |