CN101337936B - 一种用柱色谱法纯化苯磺酸阿曲库铵的方法 - Google Patents
一种用柱色谱法纯化苯磺酸阿曲库铵的方法 Download PDFInfo
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- CN101337936B CN101337936B CN2007101281267A CN200710128126A CN101337936B CN 101337936 B CN101337936 B CN 101337936B CN 2007101281267 A CN2007101281267 A CN 2007101281267A CN 200710128126 A CN200710128126 A CN 200710128126A CN 101337936 B CN101337936 B CN 101337936B
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- phenylsulfonic acid
- column chromatography
- atracurium
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CN2007101281267A CN101337936B (zh) | 2007-07-06 | 2007-07-06 | 一种用柱色谱法纯化苯磺酸阿曲库铵的方法 |
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CN2007101281267A CN101337936B (zh) | 2007-07-06 | 2007-07-06 | 一种用柱色谱法纯化苯磺酸阿曲库铵的方法 |
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CN101337936A CN101337936A (zh) | 2009-01-07 |
CN101337936B true CN101337936B (zh) | 2011-03-23 |
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CN2007101281267A Active CN101337936B (zh) | 2007-07-06 | 2007-07-06 | 一种用柱色谱法纯化苯磺酸阿曲库铵的方法 |
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Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2008222298A1 (en) | 2007-03-08 | 2008-09-12 | Chemagis Ltd. | (1R,1'R)-atracurium salts separation process |
AU2008243747B2 (en) | 2007-05-01 | 2013-03-07 | Chemagis Ltd. | Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
EP2155684B1 (en) | 2007-05-01 | 2014-04-09 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
US8357805B2 (en) | 2007-06-18 | 2013-01-22 | Chemagis Ltd. | (1R,1′R)-atracurium salts separation process |
US8354537B2 (en) | 2007-10-29 | 2013-01-15 | Chemagis Ltd. | R,R1-atracurium salts |
CN105277647A (zh) * | 2015-12-03 | 2016-01-27 | 上药东英(江苏)药业有限公司 | Hplc测定原料苯磺顺阿曲库铵含量的方法 |
CN114014806A (zh) * | 2021-12-03 | 2022-02-08 | 江苏诚信药业有限公司 | 一种新晶型顺苯磺酸阿曲库铵及其结晶方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179507A (en) * | 1975-12-10 | 1979-12-18 | Burroughs Wellcome Co. | Quarternary ammonium compounds |
GB1579822A (en) * | 1976-10-29 | 1980-11-26 | Wellcome Found | Tetrahydroisoquinolinium muscle relaxants |
WO1992000965A1 (en) * | 1990-07-13 | 1992-01-23 | The Wellcome Foundation Limited | Neuromuscular blocking agents |
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- 2007-07-06 CN CN2007101281267A patent/CN101337936B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179507A (en) * | 1975-12-10 | 1979-12-18 | Burroughs Wellcome Co. | Quarternary ammonium compounds |
GB1579822A (en) * | 1976-10-29 | 1980-11-26 | Wellcome Found | Tetrahydroisoquinolinium muscle relaxants |
WO1992000965A1 (en) * | 1990-07-13 | 1992-01-23 | The Wellcome Foundation Limited | Neuromuscular blocking agents |
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CN101337936A (zh) | 2009-01-07 |
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Effective date of registration: 20130723 Address after: 222047 Kunlun Road, Lianyungang economic and Technological Development Zone, Jiangsu, No. 7 Patentee after: Hengrui Medicine Co., Ltd., Jiangsu Prov. Patentee after: Hengrui Pharmaceutical Co., Ltd., Shanghai Address before: 222002 No. 145, Renmin East Road, Sinpo District, Jiangsu, Lianyungang Patentee before: Hengrui Medicine Co., Ltd., Jiangsu Prov. |