CN101337935B - 一种用两相萃取法纯化苯磺酸阿曲库铵的方法 - Google Patents
一种用两相萃取法纯化苯磺酸阿曲库铵的方法 Download PDFInfo
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- CN101337935B CN101337935B CN2007101281252A CN200710128125A CN101337935B CN 101337935 B CN101337935 B CN 101337935B CN 2007101281252 A CN2007101281252 A CN 2007101281252A CN 200710128125 A CN200710128125 A CN 200710128125A CN 101337935 B CN101337935 B CN 101337935B
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- atracurium
- phenylsulfonic acid
- solvent
- aqueous phase
- extraction
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Abstract
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CN2007101281252A CN101337935B (zh) | 2007-07-06 | 2007-07-06 | 一种用两相萃取法纯化苯磺酸阿曲库铵的方法 |
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CN2007101281252A CN101337935B (zh) | 2007-07-06 | 2007-07-06 | 一种用两相萃取法纯化苯磺酸阿曲库铵的方法 |
Publications (2)
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CN101337935A CN101337935A (zh) | 2009-01-07 |
CN101337935B true CN101337935B (zh) | 2011-01-12 |
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CN2007101281252A Active CN101337935B (zh) | 2007-07-06 | 2007-07-06 | 一种用两相萃取法纯化苯磺酸阿曲库铵的方法 |
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Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2125742A2 (en) | 2007-03-08 | 2009-12-02 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
CA2685488A1 (en) | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
WO2008132748A1 (en) | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
EP2132181A1 (en) | 2007-06-18 | 2009-12-16 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
US8354537B2 (en) | 2007-10-29 | 2013-01-15 | Chemagis Ltd. | R,R1-atracurium salts |
CN104557703B (zh) * | 2015-01-27 | 2018-01-16 | 江苏嘉逸医药有限公司 | 一种苯磺顺阿曲库铵精制方法 |
CN114014806A (zh) * | 2021-12-03 | 2022-02-08 | 江苏诚信药业有限公司 | 一种新晶型顺苯磺酸阿曲库铵及其结晶方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179507A (en) * | 1975-12-10 | 1979-12-18 | Burroughs Wellcome Co. | Quarternary ammonium compounds |
GB1579822A (en) * | 1976-10-29 | 1980-11-26 | Wellcome Found | Tetrahydroisoquinolinium muscle relaxants |
WO1992000965A1 (en) * | 1990-07-13 | 1992-01-23 | The Wellcome Foundation Limited | Neuromuscular blocking agents |
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2007
- 2007-07-06 CN CN2007101281252A patent/CN101337935B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179507A (en) * | 1975-12-10 | 1979-12-18 | Burroughs Wellcome Co. | Quarternary ammonium compounds |
GB1579822A (en) * | 1976-10-29 | 1980-11-26 | Wellcome Found | Tetrahydroisoquinolinium muscle relaxants |
WO1992000965A1 (en) * | 1990-07-13 | 1992-01-23 | The Wellcome Foundation Limited | Neuromuscular blocking agents |
Non-Patent Citations (2)
Title |
---|
刘春胜等.阿曲库铵苯磺酸盐的高效液相色谱分析.药学学报29 (1).1994,29((1)),68-73. |
刘春胜等.阿曲库铵苯磺酸盐的高效液相色谱分析.药学学报29 (1).1994,29((1)),68-73. * |
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CN101337935A (zh) | 2009-01-07 |
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Effective date of registration: 20130724 Address after: 222047 Kunlun Road, Lianyungang economic and Technological Development Zone, Jiangsu, No. 7 Patentee after: Hengrui Medicine Co., Ltd., Jiangsu Prov. Patentee after: Hengrui Pharmaceutical Co., Ltd., Shanghai Address before: 222002 No. 145, Renmin East Road, Sinpo District, Jiangsu, Lianyungang Patentee before: Hengrui Medicine Co., Ltd., Jiangsu Prov. |
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Effective date of registration: 20170623 Address after: 222047 Kunlun Road, Lianyungang economic and Technological Development Zone, Jiangsu, No. 7 Co-patentee after: Hengrui Pharmaceutical Co., Ltd., Shanghai Patentee after: Hengrui Medicine Co., Ltd., Jiangsu Prov. Co-patentee after: Jiangsu Sheng Di Pharmaceutical Co., Ltd. Address before: 222047 Kunlun Road, Lianyungang economic and Technological Development Zone, Jiangsu, No. 7 Co-patentee before: Hengrui Pharmaceutical Co., Ltd., Shanghai Patentee before: Hengrui Medicine Co., Ltd., Jiangsu Prov. |