FR2411829A1 - Derives de tetrapeptides, leurs procedes d'obtention et compositions pharmaceutiques les contenant - Google Patents

Derives de tetrapeptides, leurs procedes d'obtention et compositions pharmaceutiques les contenant

Info

Publication number
FR2411829A1
FR2411829A1 FR7835251A FR7835251A FR2411829A1 FR 2411829 A1 FR2411829 A1 FR 2411829A1 FR 7835251 A FR7835251 A FR 7835251A FR 7835251 A FR7835251 A FR 7835251A FR 2411829 A1 FR2411829 A1 FR 2411829A1
Authority
FR
France
Prior art keywords
tetrapeptides
derivatives
obtaining
methods
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7835251A
Other languages
English (en)
Other versions
FR2411829B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reckitt Benckiser Healthcare UK Ltd
Original Assignee
Reckitt and Colman Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt and Colman Products Ltd filed Critical Reckitt and Colman Products Ltd
Publication of FR2411829A1 publication Critical patent/FR2411829A1/fr
Application granted granted Critical
Publication of FR2411829B1 publication Critical patent/FR2411829B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DERIVES DE TETRAPEPTIDES, LEURS PROCEDES D'OBTENTION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. LES COMPOSES ONT POUR FORMULE: (CF DESSIN DANS BOPI) (R, R : H OU SUBSTITUANTS; R : SUBSTITUANTS, B ET D : RESTES D'AMINO-ACIDES). CES COMPOSES ONT DE L'AFFINITE POUR LES SITES RECEPTEURS DES BUSTANCES OPIACEES ET SONT DONC DES ANALGESIQUES A ADMINISTRER PAR INJECTION.
FR7835251A 1977-12-15 1978-12-14 Derives de tetrapeptides, leurs procedes d'obtention et compositions pharmaceutiques les contenant Granted FR2411829A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5223777 1977-12-15
GB1384578 1978-04-08

Publications (2)

Publication Number Publication Date
FR2411829A1 true FR2411829A1 (fr) 1979-07-13
FR2411829B1 FR2411829B1 (fr) 1983-11-18

Family

ID=26250049

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7835251A Granted FR2411829A1 (fr) 1977-12-15 1978-12-14 Derives de tetrapeptides, leurs procedes d'obtention et compositions pharmaceutiques les contenant

Country Status (25)

Country Link
US (1) US4178371A (fr)
JP (1) JPS5490142A (fr)
AT (1) AT363198B (fr)
AU (1) AU523732B2 (fr)
CA (1) CA1145330A (fr)
CH (1) CH638177A5 (fr)
CS (1) CS210679B2 (fr)
DD (1) DD140562A5 (fr)
DE (1) DE2854105A1 (fr)
DK (1) DK540678A (fr)
ES (1) ES475997A1 (fr)
FI (1) FI783751A (fr)
FR (1) FR2411829A1 (fr)
GR (1) GR72716B (fr)
IE (1) IE47764B1 (fr)
IL (1) IL56181A (fr)
IT (1) IT7869853A0 (fr)
LU (1) LU80654A1 (fr)
NL (1) NL7812166A (fr)
NZ (1) NZ189047A (fr)
PL (1) PL114981B1 (fr)
PT (1) PT68900A (fr)
SE (1) SE7812720L (fr)
SU (1) SU793386A3 (fr)
ZA (1) ZA786966B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2493311A1 (fr) * 1980-11-03 1982-05-07 Searle & Co Derives 2,6-c-dimethyltyrosine1-(d-amino-acide)2-(acide e-amino-caproique et acide g-aminobutyrique)5 de la methionine-encephaline, utiles notamment comme analgesiques
EP0136720A2 (fr) * 1983-10-06 1985-04-10 G.D. Searle & Co. Analogues d'encéphaline
WO1996030395A2 (fr) * 1995-03-31 1996-10-03 Takeda Chemical Industries, Ltd. Inhibiteur de la protease de cysteine

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4259234A (en) * 1976-09-27 1981-03-31 Eli Lilly And Company Analgesic compounds
US4322342A (en) * 1977-06-20 1982-03-30 Eli Lilly And Company Analgesic compounds
US4254024A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Tetrapeptides and derivatives having opiate activity
JPS5692846A (en) * 1979-12-27 1981-07-27 Takeda Chem Ind Ltd Tetrapeptide derivative and its preparation
HU181013B (en) * 1980-01-25 1983-05-30 Gyogyszerkutato Intezet Process for preparing new enkephalin analogues
WO1982000640A1 (fr) * 1980-08-18 1982-03-04 Akita T Derives de tripeptides alkylamide
ATE16495T1 (de) * 1981-06-22 1985-11-15 Ici Plc Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen.
US4450155A (en) * 1981-07-24 1984-05-22 Sterling Drug Inc. Analgesic dipeptide amides and method of use and compositions thereof
US4454120A (en) * 1981-07-24 1984-06-12 Sterling Drug Inc. Analgesic dipeptide amides and method of use and compositions thereof
US4533657A (en) * 1981-07-24 1985-08-06 Sterling Drug Inc. Analgesic dipeptide amides and method of use and composition thereof
US4658013A (en) * 1981-07-28 1987-04-14 Sterling Drug Inc. Analgesic and/or opiate antagonist tripeptide amides and processes for preparation and compositions thereof
US4407746A (en) * 1981-12-14 1983-10-04 G. D. Searle & Co. Cyclohexyl and phenyl substituted enkephalins
AU566643B2 (en) * 1982-02-05 1987-10-29 Wellcome Foundation Limited, The Pentapeptides as analgesics
US4430327A (en) 1982-05-18 1984-02-07 Eli Lilly And Company Method for treating pregnant females for pain and anxiety
GB8314646D0 (en) * 1983-05-26 1983-06-29 Wellcome Found Pharmaceutical amides
US4495178A (en) * 1983-10-06 1985-01-22 G. D. Searle & Co. Enkephalin analogs
FR2788518B1 (fr) * 1999-01-14 2001-03-02 Centre Nat Rech Scient Nouveaux carbamates actives stables, leur procede de preparation et leur utilisation pour la preparation d'urees
US20080033167A1 (en) * 2005-12-29 2008-02-07 Gilles Guichard Compositions and methods for synthesizing heterocyclic therapeutic compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2339590A1 (fr) * 1976-02-02 1977-08-26 Sandoz Sa Nouveaux composes polypeptidiques, leur preparation et leur application comme medicaments
FR2347336A1 (fr) * 1976-04-08 1977-11-04 Ici Ltd Derives peptidiques

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2339590A1 (fr) * 1976-02-02 1977-08-26 Sandoz Sa Nouveaux composes polypeptidiques, leur preparation et leur application comme medicaments
FR2347336A1 (fr) * 1976-04-08 1977-11-04 Ici Ltd Derives peptidiques

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2493311A1 (fr) * 1980-11-03 1982-05-07 Searle & Co Derives 2,6-c-dimethyltyrosine1-(d-amino-acide)2-(acide e-amino-caproique et acide g-aminobutyrique)5 de la methionine-encephaline, utiles notamment comme analgesiques
EP0136720A2 (fr) * 1983-10-06 1985-04-10 G.D. Searle & Co. Analogues d'encéphaline
EP0136720A3 (en) * 1983-10-06 1987-05-06 G.D. Searle & Co. Enkephalin analogs
WO1996030395A2 (fr) * 1995-03-31 1996-10-03 Takeda Chemical Industries, Ltd. Inhibiteur de la protease de cysteine
WO1996030395A3 (fr) * 1995-03-31 1996-12-27 Takeda Chemical Industries Ltd Inhibiteur de la protease de cysteine

Also Published As

Publication number Publication date
US4178371A (en) 1979-12-11
AT363198B (de) 1981-07-10
IE47764B1 (en) 1984-06-13
ES475997A1 (es) 1979-11-01
ZA786966B (en) 1980-11-26
LU80654A1 (fr) 1980-07-21
GR72716B (fr) 1983-12-01
IL56181A0 (en) 1979-03-12
NL7812166A (nl) 1979-06-19
IT7869853A0 (it) 1978-12-14
PL114981B1 (en) 1981-03-31
SU793386A3 (ru) 1980-12-30
IE782475L (en) 1979-06-15
AU4219978A (en) 1979-06-21
AU523732B2 (en) 1982-08-12
DK540678A (da) 1979-07-06
PT68900A (en) 1979-01-01
NZ189047A (en) 1981-12-15
DD140562A5 (de) 1980-03-12
FR2411829B1 (fr) 1983-11-18
IL56181A (en) 1982-05-31
CS210679B2 (en) 1982-01-29
CA1145330A (fr) 1983-04-26
SE7812720L (sv) 1979-06-16
DE2854105A1 (de) 1979-06-21
PL211703A1 (pl) 1979-08-13
FI783751A (fi) 1979-06-16
JPS5490142A (en) 1979-07-17
ATA899878A (de) 1980-12-15
CH638177A5 (fr) 1983-09-15

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Legal Events

Date Code Title Description
ST Notification of lapse