DD140562A5 - Verfahren zur herstellung von peptiden - Google Patents

Verfahren zur herstellung von peptiden Download PDF

Info

Publication number
DD140562A5
DD140562A5 DD78209811A DD20981178A DD140562A5 DD 140562 A5 DD140562 A5 DD 140562A5 DD 78209811 A DD78209811 A DD 78209811A DD 20981178 A DD20981178 A DD 20981178A DD 140562 A5 DD140562 A5 DD 140562A5
Authority
DD
German Democratic Republic
Prior art keywords
gly
compound
hydrogen
formula
tyr
Prior art date
Application number
DD78209811A
Other languages
German (de)
English (en)
Inventor
Barry A Morgan
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of DD140562A5 publication Critical patent/DD140562A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DD78209811A 1977-12-15 1978-12-15 Verfahren zur herstellung von peptiden DD140562A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5223777 1977-12-15
GB1384578 1978-04-08

Publications (1)

Publication Number Publication Date
DD140562A5 true DD140562A5 (de) 1980-03-12

Family

ID=26250049

Family Applications (1)

Application Number Title Priority Date Filing Date
DD78209811A DD140562A5 (de) 1977-12-15 1978-12-15 Verfahren zur herstellung von peptiden

Country Status (25)

Country Link
US (1) US4178371A (fr)
JP (1) JPS5490142A (fr)
AT (1) AT363198B (fr)
AU (1) AU523732B2 (fr)
CA (1) CA1145330A (fr)
CH (1) CH638177A5 (fr)
CS (1) CS210679B2 (fr)
DD (1) DD140562A5 (fr)
DE (1) DE2854105A1 (fr)
DK (1) DK540678A (fr)
ES (1) ES475997A1 (fr)
FI (1) FI783751A (fr)
FR (1) FR2411829A1 (fr)
GR (1) GR72716B (fr)
IE (1) IE47764B1 (fr)
IL (1) IL56181A (fr)
IT (1) IT7869853A0 (fr)
LU (1) LU80654A1 (fr)
NL (1) NL7812166A (fr)
NZ (1) NZ189047A (fr)
PL (1) PL114981B1 (fr)
PT (1) PT68900A (fr)
SE (1) SE7812720L (fr)
SU (1) SU793386A3 (fr)
ZA (1) ZA786966B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4259234A (en) * 1976-09-27 1981-03-31 Eli Lilly And Company Analgesic compounds
US4322342A (en) * 1977-06-20 1982-03-30 Eli Lilly And Company Analgesic compounds
US4254024A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Tetrapeptides and derivatives having opiate activity
JPS5692846A (en) * 1979-12-27 1981-07-27 Takeda Chem Ind Ltd Tetrapeptide derivative and its preparation
HU181013B (en) * 1980-01-25 1983-05-30 Gyogyszerkutato Intezet Process for preparing new enkephalin analogues
WO1982000640A1 (fr) * 1980-08-18 1982-03-04 Akita T Derives de tripeptides alkylamide
US4316892A (en) * 1980-11-03 1982-02-23 G. D. Searle & Co. 2,6-C-Dimethyltyrosine1 -D-amino acid2 -ε-amino caproic and γ aminobutyric acid5 derivatives of methionine enkephalin
EP0076557B1 (fr) * 1981-06-22 1985-11-13 Imperial Chemical Industries Plc Peptides et pseudopeptides ayant au N-terminus deux substituants
US4533657A (en) * 1981-07-24 1985-08-06 Sterling Drug Inc. Analgesic dipeptide amides and method of use and composition thereof
US4450155A (en) * 1981-07-24 1984-05-22 Sterling Drug Inc. Analgesic dipeptide amides and method of use and compositions thereof
US4454120A (en) * 1981-07-24 1984-06-12 Sterling Drug Inc. Analgesic dipeptide amides and method of use and compositions thereof
US4658013A (en) * 1981-07-28 1987-04-14 Sterling Drug Inc. Analgesic and/or opiate antagonist tripeptide amides and processes for preparation and compositions thereof
US4407746A (en) * 1981-12-14 1983-10-04 G. D. Searle & Co. Cyclohexyl and phenyl substituted enkephalins
US4489062A (en) * 1982-02-05 1984-12-18 Lowe Lawrence A Pharmaceutical compounds, preparation, use and intermediates therefor and their preparation
US4430327A (en) 1982-05-18 1984-02-07 Eli Lilly And Company Method for treating pregnant females for pain and anxiety
GB8314646D0 (en) * 1983-05-26 1983-06-29 Wellcome Found Pharmaceutical amides
US4603121A (en) * 1983-10-06 1986-07-29 G. D. Searle & Co. Enkephalin analogs
US4495178A (en) * 1983-10-06 1985-01-22 G. D. Searle & Co. Enkephalin analogs
CA2215211A1 (fr) * 1995-03-31 1996-10-03 Takeda Chemical Industries, Ltd. Inhibiteur de la protease de cysteine
FR2788518B1 (fr) * 1999-01-14 2001-03-02 Centre Nat Rech Scient Nouveaux carbamates actives stables, leur procede de preparation et leur utilisation pour la preparation d'urees
US7777030B2 (en) * 2005-12-29 2010-08-17 Centre National de la Recherge Scientifique (CNRS) Compositions and methods for the treatment and prevention of disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2702711A1 (de) * 1976-02-02 1977-08-04 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
NZ183712A (en) * 1976-04-08 1979-10-25 Ici Ltd Polypeptide analogues of enkephalins, and pharmaceutical compositions

Also Published As

Publication number Publication date
ATA899878A (de) 1980-12-15
NL7812166A (nl) 1979-06-19
DE2854105A1 (de) 1979-06-21
PL211703A1 (pl) 1979-08-13
IL56181A0 (en) 1979-03-12
ZA786966B (en) 1980-11-26
LU80654A1 (fr) 1980-07-21
AT363198B (de) 1981-07-10
FR2411829B1 (fr) 1983-11-18
CS210679B2 (en) 1982-01-29
JPS5490142A (en) 1979-07-17
ES475997A1 (es) 1979-11-01
SE7812720L (sv) 1979-06-16
IE782475L (en) 1979-06-15
US4178371A (en) 1979-12-11
AU4219978A (en) 1979-06-21
PT68900A (en) 1979-01-01
FR2411829A1 (fr) 1979-07-13
GR72716B (fr) 1983-12-01
DK540678A (da) 1979-07-06
PL114981B1 (en) 1981-03-31
CA1145330A (fr) 1983-04-26
NZ189047A (en) 1981-12-15
IE47764B1 (en) 1984-06-13
IL56181A (en) 1982-05-31
CH638177A5 (fr) 1983-09-15
FI783751A (fi) 1979-06-16
AU523732B2 (en) 1982-08-12
SU793386A3 (ru) 1980-12-30
IT7869853A0 (it) 1978-12-14

Similar Documents

Publication Publication Date Title
DD140562A5 (de) Verfahren zur herstellung von peptiden
EP0871653B1 (fr) Nouveaux derives d'acide amine, procede de production correspondant et compositions pharmaceutiques contenant ces composes
DE2366379C2 (de) N↑α↑-geschützte N↑G↑-Nitro-L-arginyl-L-prolin-amide
DE2514381C3 (de) Tripeptide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2720245A1 (de) Polypeptide
DE3044793A1 (de) N-adamentansubstituierte tetrapeptidamide und deren pharmakologisch vertraegliche salze
EP0083305B1 (fr) Octapeptides cycliques, préparations pharmaceutiques les contenant et procédés de leur préparation et leur utilisation
CH634548A5 (de) Verfahren zur herstellung von neuen peptiden.
DD140142A5 (de) Verfahren zur herstellung von cyclopeptiden
EP0031303A2 (fr) Cyclooctapeptides et leurs préparations pharmaceutiques, procédé pour leur préparation et leur application
DE3024256A1 (de) Peptidamide, verfahren zur herstellung derselben und diese enthaltende arzneimittel
DE2703109A1 (de) Biologisch wirksame amide
DD200799A5 (de) Verfahren zur herstellung von peptiden
DE3143599A1 (de) 2,6-c-dimethyltyrosin(pfeil hoch)1(pfeil hoch)-d-aminosaeure(pfeil hoch)2(pfeil hoch)-(epsilon)-aminocapronsaeure- und (gamma)-aminobuttersaeure(pfeil hoch)5(pfeil hoch)-derivate von methioninenkephalin
CH615904A5 (en) Process for the preparation of L-leucine-13-motilin
DE2463205C2 (de) Octapeptid und Verfahren zu dessen Herstellung
DE2726276C2 (de) Luliberin-Antagonisten, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Zusammensetzungen
DE2731308A1 (de) Psychopharmakologisch wirksame peptide und peptidderivate und verfahren zu deren herstellung
DE3340208C2 (fr)
DE2649114A1 (de) Octapeptide
DE2342862A1 (de) Verfahren zur herstellung von an beiden kettenenden alpha-aminooxysaeuren enthaltenden peptiden mit acth-wirkung
DE2754770C2 (de) N-Acyltetrapeptidamide, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2759031A1 (de) Eine aminooxyacylgruppe aufweisende peptide, solche enthaltende arzneimittel beziehungsweise diagnostica und verfahren zur herstellung derselben
DE2341775A1 (de) Verfahren zur herstellung von neuen, in n-terminaler stellung alpha-aminooxysaeuren enthaltenden peptiden mit acthwirkung
DE3537405A1 (de) Biologisch aktive penta- und heptapeptide, verfahren zu deren herstellung und arzneimittel, welche diese enthalten