ATE16495T1 - Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen. - Google Patents

Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen.

Info

Publication number
ATE16495T1
ATE16495T1 AT82302471T AT82302471T ATE16495T1 AT E16495 T1 ATE16495 T1 AT E16495T1 AT 82302471 T AT82302471 T AT 82302471T AT 82302471 T AT82302471 T AT 82302471T AT E16495 T1 ATE16495 T1 AT E16495T1
Authority
AT
Austria
Prior art keywords
amino acid
stand
compounds
linkages
acid residue
Prior art date
Application number
AT82302471T
Other languages
English (en)
Inventor
James Joseph Gormley
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Application granted granted Critical
Publication of ATE16495T1 publication Critical patent/ATE16495T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Anesthesiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT82302471T 1981-06-22 1982-05-14 Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen. ATE16495T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8119163 1981-06-22
EP82302471A EP0076557B1 (de) 1981-06-22 1982-05-14 Peptide und Pseudopeptide, die zwei Substituenten am N-Terminus aufweisen

Publications (1)

Publication Number Publication Date
ATE16495T1 true ATE16495T1 (de) 1985-11-15

Family

ID=10522716

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82302471T ATE16495T1 (de) 1981-06-22 1982-05-14 Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen.

Country Status (5)

Country Link
US (1) US4421744A (de)
EP (1) EP0076557B1 (de)
JP (1) JPS57212148A (de)
AT (1) ATE16495T1 (de)
DE (1) DE3267380D1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834433A (en) * 1990-07-26 1998-11-10 Merrell Pharmaceuticals Inc. Compounds and pharmaceutical uses of peptides of bombesin and GRP
ES2106188T3 (es) * 1991-05-23 1997-11-01 Merrell Pharma Inc Analogos de bombesina.
WO1993016105A1 (en) * 1992-02-07 1993-08-19 Merrell Dow Pharmaceuticals Inc. Phenylalanine analogs of bombesin
ATE197157T1 (de) * 1994-03-17 2000-11-15 Fujirebio Kk Azapeptid-derivate
US5789443A (en) * 1997-04-25 1998-08-04 Gollobin; Charlotte Method for treating flushing associated with menopause
US6245812B1 (en) 1999-07-15 2001-06-12 Charlotte Gollobin Treatment of hot flashes (flushing) using leucine alone or in combination with other branched chain amino acids
ES2308181T3 (es) * 2003-05-30 2008-12-01 Prozymex A/S Inhibidores de proteasa.
US7956220B2 (en) 2005-07-01 2011-06-07 Jenrin Discovery MAO-B inhibitors useful for treating obesity

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254106A (en) * 1976-01-26 1981-03-03 Burroughs Wellcome Co. Biologically active amides
US4261888A (en) * 1976-04-12 1981-04-14 Sandoz Ltd. Organic compounds
DK326477A (da) * 1976-07-27 1978-01-28 Reckitt & Colmann Prod Ltd Kemiske forbindelser og fremgangsmade til fremstilling af samme
US4259234A (en) * 1976-09-27 1981-03-31 Eli Lilly And Company Analgesic compounds
GB1513768A (en) * 1976-10-20 1978-06-07 Reckitt & Colmann Prod Ltd Tetrapeptides and pentapeptides
DE2819277A1 (de) * 1977-05-16 1978-11-23 Sandoz Ag Neue polypeptidderivate, ihre herstellung und verwendung
US4322342A (en) * 1977-06-20 1982-03-30 Eli Lilly And Company Analgesic compounds
GB2000784B (en) * 1977-07-05 1982-01-20 American Home Prod Analgesic polypetide
US4198398A (en) * 1977-07-12 1980-04-15 Derek Hudson Enkephalin analogues
GB1604850A (en) * 1977-11-24 1981-12-16 Wellcome Found Biologically active peptides
NZ188372A (en) * 1977-09-29 1981-05-01 Reckitt & Colmann Prod Ltd Peptide derivatives and pharmaceutical compositions
US4264491A (en) * 1977-10-03 1981-04-28 Eli Lilly And Company Analgesic compounds
US4178371A (en) * 1977-12-15 1979-12-11 Reckitt & Colman Products Limited Tetrapeptide derivatives
US4148785A (en) * 1978-03-15 1979-04-10 American Home Products Corporation Analgesic polypeptide
US4148786A (en) * 1978-06-26 1979-04-10 American Home Products Corporation Analgesic polypeptide
US4278596A (en) * 1978-08-08 1981-07-14 American Home Products Corporation Analgesic pentapeptides
US4216127A (en) * 1979-07-05 1980-08-05 American Home Products Corporation Enkephalin analogues
US4216128A (en) * 1979-07-05 1980-08-05 American Home Products Corporation Enkephalin analogues
DE2941790A1 (de) * 1979-10-16 1981-04-30 Hoechst Ag, 6000 Frankfurt Verwendung motilitaetssteigernder peptide
US4320051A (en) * 1979-12-26 1982-03-16 American Home Products Corporation Analgesic tripeptide amides
US4322340A (en) * 1980-10-20 1982-03-30 Eli Lilly And Company Pharmacologically active peptides

Also Published As

Publication number Publication date
EP0076557A2 (de) 1983-04-13
EP0076557A3 (en) 1983-05-25
JPS57212148A (en) 1982-12-27
DE3267380D1 (en) 1985-12-19
EP0076557B1 (de) 1985-11-13
US4421744A (en) 1983-12-20

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