ATE16495T1 - Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen. - Google Patents
Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen.Info
- Publication number
- ATE16495T1 ATE16495T1 AT82302471T AT82302471T ATE16495T1 AT E16495 T1 ATE16495 T1 AT E16495T1 AT 82302471 T AT82302471 T AT 82302471T AT 82302471 T AT82302471 T AT 82302471T AT E16495 T1 ATE16495 T1 AT E16495T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- stand
- compounds
- linkages
- acid residue
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 125000000539 amino acid group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108090000137 Opioid Receptors Proteins 0.000 abstract 1
- 102000003840 Opioid Receptors Human genes 0.000 abstract 1
- 101100244562 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprD gene Proteins 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 108700023159 delta Opioid Receptors Proteins 0.000 abstract 1
- 102000048124 delta Opioid Receptors Human genes 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/70—Enkephalins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Anesthesiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8119163 | 1981-06-22 | ||
| EP82302471A EP0076557B1 (de) | 1981-06-22 | 1982-05-14 | Peptide und Pseudopeptide, die zwei Substituenten am N-Terminus aufweisen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE16495T1 true ATE16495T1 (de) | 1985-11-15 |
Family
ID=10522716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82302471T ATE16495T1 (de) | 1981-06-22 | 1982-05-14 | Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4421744A (de) |
| EP (1) | EP0076557B1 (de) |
| JP (1) | JPS57212148A (de) |
| AT (1) | ATE16495T1 (de) |
| DE (1) | DE3267380D1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5834433A (en) * | 1990-07-26 | 1998-11-10 | Merrell Pharmaceuticals Inc. | Compounds and pharmaceutical uses of peptides of bombesin and GRP |
| ATE156492T1 (de) * | 1991-05-23 | 1997-08-15 | Merrell Pharma Inc | Bombesinanaloge |
| JPH07505865A (ja) * | 1992-02-07 | 1995-06-29 | メレルダウファーマスーティカルズ インコーポレイテッド | ボンベシンのフェニルアラニン類似体類 |
| ATE197157T1 (de) * | 1994-03-17 | 2000-11-15 | Fujirebio Kk | Azapeptid-derivate |
| US5789443A (en) * | 1997-04-25 | 1998-08-04 | Gollobin; Charlotte | Method for treating flushing associated with menopause |
| US6245812B1 (en) | 1999-07-15 | 2001-06-12 | Charlotte Gollobin | Treatment of hot flashes (flushing) using leucine alone or in combination with other branched chain amino acids |
| DK1633702T3 (da) * | 2003-05-30 | 2008-11-10 | Prozymex As | Proteaseinhibitorer |
| AU2006265639A1 (en) | 2005-07-01 | 2007-01-11 | Jenrin Discovery | MAO-B inhibitors useful for treating obesity |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4254106A (en) * | 1976-01-26 | 1981-03-03 | Burroughs Wellcome Co. | Biologically active amides |
| US4261888A (en) * | 1976-04-12 | 1981-04-14 | Sandoz Ltd. | Organic compounds |
| DK326477A (da) * | 1976-07-27 | 1978-01-28 | Reckitt & Colmann Prod Ltd | Kemiske forbindelser og fremgangsmade til fremstilling af samme |
| US4259234A (en) * | 1976-09-27 | 1981-03-31 | Eli Lilly And Company | Analgesic compounds |
| GB1513768A (en) * | 1976-10-20 | 1978-06-07 | Reckitt & Colmann Prod Ltd | Tetrapeptides and pentapeptides |
| DE2819277A1 (de) * | 1977-05-16 | 1978-11-23 | Sandoz Ag | Neue polypeptidderivate, ihre herstellung und verwendung |
| US4322342A (en) * | 1977-06-20 | 1982-03-30 | Eli Lilly And Company | Analgesic compounds |
| GB2000784B (en) * | 1977-07-05 | 1982-01-20 | American Home Prod | Analgesic polypetide |
| US4198398A (en) * | 1977-07-12 | 1980-04-15 | Derek Hudson | Enkephalin analogues |
| GB1604850A (en) * | 1977-11-24 | 1981-12-16 | Wellcome Found | Biologically active peptides |
| NZ188372A (en) * | 1977-09-29 | 1981-05-01 | Reckitt & Colmann Prod Ltd | Peptide derivatives and pharmaceutical compositions |
| US4264491A (en) * | 1977-10-03 | 1981-04-28 | Eli Lilly And Company | Analgesic compounds |
| US4178371A (en) * | 1977-12-15 | 1979-12-11 | Reckitt & Colman Products Limited | Tetrapeptide derivatives |
| US4148785A (en) * | 1978-03-15 | 1979-04-10 | American Home Products Corporation | Analgesic polypeptide |
| US4148786A (en) * | 1978-06-26 | 1979-04-10 | American Home Products Corporation | Analgesic polypeptide |
| US4278596A (en) * | 1978-08-08 | 1981-07-14 | American Home Products Corporation | Analgesic pentapeptides |
| US4216128A (en) * | 1979-07-05 | 1980-08-05 | American Home Products Corporation | Enkephalin analogues |
| US4216127A (en) * | 1979-07-05 | 1980-08-05 | American Home Products Corporation | Enkephalin analogues |
| DE2941790A1 (de) * | 1979-10-16 | 1981-04-30 | Hoechst Ag, 6000 Frankfurt | Verwendung motilitaetssteigernder peptide |
| US4320051A (en) * | 1979-12-26 | 1982-03-16 | American Home Products Corporation | Analgesic tripeptide amides |
| US4322340A (en) * | 1980-10-20 | 1982-03-30 | Eli Lilly And Company | Pharmacologically active peptides |
-
1982
- 1982-05-14 DE DE8282302471T patent/DE3267380D1/de not_active Expired
- 1982-05-14 AT AT82302471T patent/ATE16495T1/de active
- 1982-05-14 EP EP82302471A patent/EP0076557B1/de not_active Expired
- 1982-05-18 US US06/379,614 patent/US4421744A/en not_active Expired - Fee Related
- 1982-06-04 JP JP57095059A patent/JPS57212148A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US4421744A (en) | 1983-12-20 |
| DE3267380D1 (en) | 1985-12-19 |
| EP0076557A3 (en) | 1983-05-25 |
| JPS57212148A (en) | 1982-12-27 |
| EP0076557B1 (de) | 1985-11-13 |
| EP0076557A2 (de) | 1983-04-13 |
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