ATE197157T1 - Azapeptid-derivate - Google Patents

Azapeptid-derivate

Info

Publication number
ATE197157T1
ATE197157T1 AT95103948T AT95103948T ATE197157T1 AT E197157 T1 ATE197157 T1 AT E197157T1 AT 95103948 T AT95103948 T AT 95103948T AT 95103948 T AT95103948 T AT 95103948T AT E197157 T1 ATE197157 T1 AT E197157T1
Authority
AT
Austria
Prior art keywords
group
protected
salt
lower alkyl
formula
Prior art date
Application number
AT95103948T
Other languages
English (en)
Inventor
Yoshiharu Nakashima
Michiyo Hizuka
Yasushi Higashide
Tetsuaki Yamaura
Hiroshi Ikawa
Original Assignee
Fujirebio Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujirebio Kk filed Critical Fujirebio Kk
Application granted granted Critical
Publication of ATE197157T1 publication Critical patent/ATE197157T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
AT95103948T 1994-03-17 1995-03-17 Azapeptid-derivate ATE197157T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4720694 1994-03-17
JP8054794 1994-04-19

Publications (1)

Publication Number Publication Date
ATE197157T1 true ATE197157T1 (de) 2000-11-15

Family

ID=26387364

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95103948T ATE197157T1 (de) 1994-03-17 1995-03-17 Azapeptid-derivate

Country Status (5)

Country Link
US (2) US5837687A (de)
EP (1) EP0672678B1 (de)
KR (1) KR100344607B1 (de)
AT (1) ATE197157T1 (de)
DE (1) DE69519182T2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998048826A1 (en) * 1997-04-30 1998-11-05 Northwestern University Inhibition of nitric oxide synthase by amino acids and dipeptides
AU2001234837A1 (en) * 2000-02-08 2001-08-20 Schering Corporation Azapeptides useful in the treatment of hepatitis c
CN1724514B (zh) * 2004-07-19 2010-06-09 上海依福瑞实业有限公司 一种l－高精氨酸盐酸盐的制备方法
GB0516610D0 (en) * 2005-08-12 2005-09-21 Sosei Co Ltd Compounds for use in therapy
GB0614970D0 (en) * 2006-07-27 2006-09-06 R & D Sosei Ltd Compounds For Use In Therapy

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE16495T1 (de) * 1981-06-22 1985-11-15 Ici Plc Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen.
US5410019A (en) * 1987-09-24 1995-04-25 The Administrators Of The Tulane-Educational Fund Therapeutic peptides
US5164372A (en) * 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
IT1233696B (it) * 1989-05-29 1992-04-14 Menarini Farma Ind Peptidi di sintesi antagonisti della neurochinina a. loro sali e relativi procedimenti di fabbricazione
GB8929070D0 (en) * 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
US5420297A (en) * 1990-10-24 1995-05-30 Fujisawa Pharmaceutical Co., Ltd. Peptides having substance P antagonistic activity
FR2677362B1 (fr) * 1991-06-04 1995-04-28 Centre Nat Rech Scient Neuropeptides de la famille des tachykinines.
GB9112825D0 (en) * 1991-06-14 1991-07-31 Ici Plc Process for making peptides
US5654400A (en) * 1991-10-04 1997-08-05 Fujisawa Pharmaceutical Co., Ltd. Process for making peptide compounds having tachykinin antagonistic activity
FR2684674B1 (fr) * 1991-12-10 1994-01-28 Thevac Sarl Azapeptides et leur procede de preparation.
GB9319776D0 (en) * 1993-09-24 1993-11-10 Medical Res Council Azapeptide synthesis

Also Published As

Publication number Publication date
DE69519182T2 (de) 2001-05-17
DE69519182D1 (de) 2000-11-30
US5837687A (en) 1998-11-17
KR100344607B1 (ko) 2002-11-20
EP0672678B1 (de) 2000-10-25
EP0672678A1 (de) 1995-09-20
US5965538A (en) 1999-10-12
KR950032271A (ko) 1995-12-20

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties