DE69519182D1 - Azapeptid-Derivate - Google Patents

Azapeptid-Derivate

Info

Publication number
DE69519182D1
DE69519182D1 DE69519182T DE69519182T DE69519182D1 DE 69519182 D1 DE69519182 D1 DE 69519182D1 DE 69519182 T DE69519182 T DE 69519182T DE 69519182 T DE69519182 T DE 69519182T DE 69519182 D1 DE69519182 D1 DE 69519182D1
Authority
DE
Germany
Prior art keywords
group
protected
salt
lower alkyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69519182T
Other languages
English (en)
Other versions
DE69519182T2 (de
Inventor
Yoshiharu Nakashima
Michiyo Hizuka
Yasushi Higashide
Tetsuaki Yamaura
Hiroshi Ikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujirebio Inc
Original Assignee
Fujirebio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujirebio Inc filed Critical Fujirebio Inc
Application granted granted Critical
Publication of DE69519182D1 publication Critical patent/DE69519182D1/de
Publication of DE69519182T2 publication Critical patent/DE69519182T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69519182T 1994-03-17 1995-03-17 Azapeptid-Derivate Expired - Fee Related DE69519182T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4720694 1994-03-17
JP8054794 1994-04-19

Publications (2)

Publication Number Publication Date
DE69519182D1 true DE69519182D1 (de) 2000-11-30
DE69519182T2 DE69519182T2 (de) 2001-05-17

Family

ID=26387364

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69519182T Expired - Fee Related DE69519182T2 (de) 1994-03-17 1995-03-17 Azapeptid-Derivate

Country Status (5)

Country Link
US (2) US5837687A (de)
EP (1) EP0672678B1 (de)
KR (1) KR100344607B1 (de)
AT (1) ATE197157T1 (de)
DE (1) DE69519182T2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7246398A (en) * 1997-04-30 1998-11-24 Northwestern University Inhibition of nitric oxide synthase by amino acids and dipeptides
US6624290B2 (en) 2000-02-08 2003-09-23 Schering Corporation Azapeptides useful in the treatment of Hepatitis C
CN1724514B (zh) * 2004-07-19 2010-06-09 上海依福瑞实业有限公司 一种l－高精氨酸盐酸盐的制备方法
GB0516610D0 (en) * 2005-08-12 2005-09-21 Sosei Co Ltd Compounds for use in therapy
GB0614970D0 (en) * 2006-07-27 2006-09-06 R & D Sosei Ltd Compounds For Use In Therapy

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3267380D1 (en) * 1981-06-22 1985-12-19 Ici Plc Peptides and pseudopeptides in which the n terminus bears two substituents
US5410019A (en) * 1987-09-24 1995-04-25 The Administrators Of The Tulane-Educational Fund Therapeutic peptides
US5164372A (en) * 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
IT1233696B (it) * 1989-05-29 1992-04-14 Menarini Farma Ind Peptidi di sintesi antagonisti della neurochinina a. loro sali e relativi procedimenti di fabbricazione
GB8929070D0 (en) * 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
US5420297A (en) * 1990-10-24 1995-05-30 Fujisawa Pharmaceutical Co., Ltd. Peptides having substance P antagonistic activity
FR2677362B1 (fr) * 1991-06-04 1995-04-28 Centre Nat Rech Scient Neuropeptides de la famille des tachykinines.
GB9112825D0 (en) * 1991-06-14 1991-07-31 Ici Plc Process for making peptides
US5654400A (en) * 1991-10-04 1997-08-05 Fujisawa Pharmaceutical Co., Ltd. Process for making peptide compounds having tachykinin antagonistic activity
FR2684674B1 (fr) * 1991-12-10 1994-01-28 Thevac Sarl Azapeptides et leur procede de preparation.
GB9319776D0 (en) * 1993-09-24 1993-11-10 Medical Res Council Azapeptide synthesis

Also Published As

Publication number Publication date
EP0672678B1 (de) 2000-10-25
KR950032271A (ko) 1995-12-20
KR100344607B1 (ko) 2002-11-20
DE69519182T2 (de) 2001-05-17
US5965538A (en) 1999-10-12
EP0672678A1 (de) 1995-09-20
US5837687A (en) 1998-11-17
ATE197157T1 (de) 2000-11-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee