ES8300087A1 - Procedimiento para preparar amidas tetrapeptidas n-adamantano-sustituidas. - Google Patents
Procedimiento para preparar amidas tetrapeptidas n-adamantano-sustituidas.Info
- Publication number
- ES8300087A1 ES8300087A1 ES508060A ES508060A ES8300087A1 ES 8300087 A1 ES8300087 A1 ES 8300087A1 ES 508060 A ES508060 A ES 508060A ES 508060 A ES508060 A ES 508060A ES 8300087 A1 ES8300087 A1 ES 8300087A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- adamantane
- amino acid
- acid residues
- various amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SISTEMA PARA TRANSMITIR MOVIMIENTOS A LOS MUÑECOS, YA SEA EN SOLITARIO O EN COMBINACION CON LA CUNA DEL MISMO. CONSTA DE UN EJE HORIZONTAL (1) SOBRE EL QUE BASCULA POR SU CENTRO UNA PALANCA EN CRUZ (2), LA CUAL TIENE SUS TERMINALES ACOPLADOS DE FORMA QUE PUEDAN DISCURRIR POR LAS RANURAS DE UNOS SALIENTES RADIALES DE LOS MUÑONES (3) DE ARTICULACION DE LOS BRAZOS DEL MUÑECO Y POR LA RANURA DE UN SALIENTE RADIAL DEL MUÑON (4) DE ARTICULACION DE LA CABEZA DEL MUÑECO; Y DE UN MECANISMO PROVISTO DE UN MOTORREDUCTOR QUE SE ALOJA DEBAJO DEL TABLERO DE LA CUNA DEL MUÑECO. CUALQUIER IMPULSO DE SUBIDA O BAJADA APLICADO A UNO DE LOS BRAZOS ES TRANSMITIDO POR LA PALANCA EN CRUZ (2) AL OTRO BRAZO Y A LA CABEZA, LA CUAL GIRA ALTERNATIVAMENTE A DERECHA O A IZQUIERDA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/099,765 US4273704A (en) | 1979-12-03 | 1979-12-03 | N-Adamantane-substituted tetrapeptide amides |
Publications (2)
Publication Number | Publication Date |
---|---|
ES508060A0 ES508060A0 (es) | 1982-10-01 |
ES8300087A1 true ES8300087A1 (es) | 1982-10-01 |
Family
ID=22276513
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES497353A Granted ES497353A0 (es) | 1979-12-03 | 1980-12-02 | Procedimiento para preparar amidas tetrapeptidas n-adamanta-nosustituidas |
ES508060A Expired ES8300087A1 (es) | 1979-12-03 | 1981-12-16 | Procedimiento para preparar amidas tetrapeptidas n-adamantano-sustituidas. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES497353A Granted ES497353A0 (es) | 1979-12-03 | 1980-12-02 | Procedimiento para preparar amidas tetrapeptidas n-adamanta-nosustituidas |
Country Status (16)
Country | Link |
---|---|
US (1) | US4273704A (es) |
JP (1) | JPS5692847A (es) |
AU (1) | AU6499080A (es) |
BE (1) | BE886472A (es) |
CA (1) | CA1151642A (es) |
DE (1) | DE3044793A1 (es) |
DK (1) | DK513480A (es) |
ES (2) | ES497353A0 (es) |
FR (1) | FR2476073A1 (es) |
GB (1) | GB2066262B (es) |
IT (1) | IT1127930B (es) |
NL (1) | NL8006586A (es) |
NO (1) | NO803640L (es) |
PT (1) | PT72141B (es) |
SE (1) | SE8008428L (es) |
ZA (1) | ZA807513B (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4404135A (en) * | 1981-07-20 | 1983-09-13 | G. D. Searle & Co. | Enkephalin derivatives |
US4407746A (en) * | 1981-12-14 | 1983-10-04 | G. D. Searle & Co. | Cyclohexyl and phenyl substituted enkephalins |
CS231221B1 (en) * | 1982-06-29 | 1984-10-15 | Martin Flegel | L-alanyl-d-isoglutamine adamantylamide |
US4629784A (en) * | 1983-08-16 | 1986-12-16 | The University Of Georgia Research Foundation, Inc. | Synthesis of cyclopropane amino acids |
DE3485587D1 (de) * | 1983-08-16 | 1992-04-23 | Univ Georgia Res Found | Herstellung von aminocyclopropancarbonsaeuren und von peptiden. |
US4510085A (en) * | 1984-04-12 | 1985-04-09 | G.D. Searle & Co. | Antihypertensive tetrapeptide amides |
US4514332A (en) * | 1984-04-16 | 1985-04-30 | G. D. Searle & Co. | Tetrapeptide adamantyl amides |
FR2572399B1 (fr) * | 1984-10-31 | 1987-01-16 | Panmedica Sa | Nouveaux derives de l'adamantanamine, leurs procedes de preparation et medicaments les contenant |
US4822775A (en) * | 1986-02-14 | 1989-04-18 | G. D. Searle & Co. | Phenyl substituted dipeptide amides |
US4880829A (en) * | 1985-08-14 | 1989-11-14 | G. D. Searle And Company | Substituted dipeptide amides #3 |
US4758675A (en) * | 1986-07-14 | 1988-07-19 | G. D. Searle & Co. | 3-thiophene-substituted tyrosyl dipeptide amides |
DK0668290T3 (da) * | 1990-02-28 | 1999-07-26 | Teikoku Seiyaku Kk | Fysiologisk aktiv substans, som er i stand til at gennemtrænge biomembranen |
US5652335A (en) * | 1990-02-28 | 1997-07-29 | Teikoku Seiyaku Kabushiki Kaisha | Physiologically active substance well capable of permeating biomembrane |
WO1998030329A1 (fr) * | 1997-01-14 | 1998-07-16 | Daicel Chemical Industries, Ltd. | Catalyseurs de nitration ou de carboxylation |
US7795468B2 (en) * | 2001-01-19 | 2010-09-14 | Chevron U.S.A. Inc. | Functionalized higher diamondoids |
US20050261302A1 (en) * | 2004-04-29 | 2005-11-24 | Hoff Ethan D | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application |
US20050245534A1 (en) * | 2004-04-29 | 2005-11-03 | Link James T | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
US20100222316A1 (en) * | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
US7880001B2 (en) * | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
US8415354B2 (en) * | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
US20080275112A1 (en) * | 2004-07-23 | 2008-11-06 | Schreiner Peter R | Invention Concerning Aminoadamantane Compounds |
CA2585735A1 (en) * | 2004-11-02 | 2006-05-11 | Pfizer Inc. | Novel compounds of substituted and unsubstituted adamantyl amides |
US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
US8198331B2 (en) * | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
KR101496206B1 (ko) * | 2005-01-05 | 2015-02-27 | 애브비 인코포레이티드 | 11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제로서의 아다만틸 유도체 |
HRP20050242B1 (en) * | 2005-03-15 | 2010-09-30 | Institut Ruđer Bošković | Synthetic peptides containing unnatural adamantane related amino acids for use as antitumour drugs |
JP5736098B2 (ja) | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
EP2399926A1 (en) * | 2010-06-22 | 2011-12-28 | Justus-Liebig-Universität Giessen | Peptides incorporating 3-aminoadamantane carboxylic acids enhance synaptic plasticity and act as neurogenic agents |
CN112552374B (zh) * | 2019-09-10 | 2024-06-04 | 西藏海思科制药有限公司 | 一种肽酰胺类化合物及其中间体的制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK326477A (da) * | 1976-07-27 | 1978-01-28 | Reckitt & Colmann Prod Ltd | Kemiske forbindelser og fremgangsmade til fremstilling af samme |
-
1979
- 1979-12-03 US US06/099,765 patent/US4273704A/en not_active Expired - Lifetime
-
1980
- 1980-11-28 DE DE19803044793 patent/DE3044793A1/de not_active Withdrawn
- 1980-12-02 CA CA000365903A patent/CA1151642A/en not_active Expired
- 1980-12-02 NO NO803640A patent/NO803640L/no unknown
- 1980-12-02 IT IT50294/80A patent/IT1127930B/it active
- 1980-12-02 SE SE8008428A patent/SE8008428L/ not_active Application Discontinuation
- 1980-12-02 AU AU64990/80A patent/AU6499080A/en not_active Withdrawn
- 1980-12-02 DK DK513480A patent/DK513480A/da not_active Application Discontinuation
- 1980-12-02 ZA ZA00807513A patent/ZA807513B/xx unknown
- 1980-12-02 ES ES497353A patent/ES497353A0/es active Granted
- 1980-12-03 BE BE0/203025A patent/BE886472A/fr unknown
- 1980-12-03 JP JP17078580A patent/JPS5692847A/ja active Pending
- 1980-12-03 NL NL8006586A patent/NL8006586A/nl not_active Application Discontinuation
- 1980-12-03 PT PT72141A patent/PT72141B/pt unknown
- 1980-12-03 FR FR8025696A patent/FR2476073A1/fr not_active Withdrawn
- 1980-12-03 GB GB8038684A patent/GB2066262B/en not_active Expired
-
1981
- 1981-12-16 ES ES508060A patent/ES8300087A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES8205753A1 (es) | 1982-06-16 |
NL8006586A (nl) | 1981-07-01 |
GB2066262A (en) | 1981-07-08 |
ES497353A0 (es) | 1982-06-16 |
IT8050294A0 (it) | 1980-12-02 |
BE886472A (fr) | 1981-06-03 |
DE3044793A1 (de) | 1981-06-19 |
NO803640L (no) | 1981-06-04 |
AU6499080A (en) | 1981-06-11 |
ES508060A0 (es) | 1982-10-01 |
CA1151642A (en) | 1983-08-09 |
IT1127930B (it) | 1986-05-28 |
ZA807513B (en) | 1982-07-28 |
FR2476073A1 (fr) | 1981-08-21 |
DK513480A (da) | 1981-07-09 |
GB2066262B (en) | 1983-05-11 |
SE8008428L (sv) | 1981-06-04 |
JPS5692847A (en) | 1981-07-27 |
PT72141A (en) | 1981-01-01 |
PT72141B (en) | 1981-10-28 |
US4273704A (en) | 1981-06-16 |
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