ES8205753A1 - Procedimiento para preparar amidas tetrapeptidas n-adamanta-nosustituidas - Google Patents
Procedimiento para preparar amidas tetrapeptidas n-adamanta-nosustituidasInfo
- Publication number
- ES8205753A1 ES8205753A1 ES497353A ES497353A ES8205753A1 ES 8205753 A1 ES8205753 A1 ES 8205753A1 ES 497353 A ES497353 A ES 497353A ES 497353 A ES497353 A ES 497353A ES 8205753 A1 ES8205753 A1 ES 8205753A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- adamantane
- amino acid
- acid residues
- various amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR AMIDAS TETRAPEPTIDAS N-ADAMANTANOSUSTITUIDAS. CONSTA DE LAS SIGUIENTES ETAPAS: 1 TRATAR UN AMINOACIDO O PEPTIDO N-PROTEGIDO DE FORMULA A-W-X-HNCH2COOH, EN QUE A REPRESENTA UN GRUPO N-PROTECTOR, EN PRESENCIA DE UNA AMINA TERCIARIA, A TEMPERATURAS INFEIRORES A -10C, CON UN ESTER DE ACIDO CLOROFORMICO (TAL COMO EL CLOROFORMATO DE ISOBUTILO). 2 ACOPLAR EL COMPUESTO RESULTANTE CON H-Y-Z. 3 DESPROTEGER EL PRODUCTO N-BLOQUEADO RESULTANTE. SE OBTIENE EL COMPUESTO DE FORMULA GENERAL W-X-G1Y-Y-Z.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/099,765 US4273704A (en) | 1979-12-03 | 1979-12-03 | N-Adamantane-substituted tetrapeptide amides |
Publications (2)
Publication Number | Publication Date |
---|---|
ES497353A0 ES497353A0 (es) | 1982-06-16 |
ES8205753A1 true ES8205753A1 (es) | 1982-06-16 |
Family
ID=22276513
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES497353A Expired ES8205753A1 (es) | 1979-12-03 | 1980-12-02 | Procedimiento para preparar amidas tetrapeptidas n-adamanta-nosustituidas |
ES508060A Expired ES8300087A1 (es) | 1979-12-03 | 1981-12-16 | Procedimiento para preparar amidas tetrapeptidas n-adamantano-sustituidas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES508060A Expired ES8300087A1 (es) | 1979-12-03 | 1981-12-16 | Procedimiento para preparar amidas tetrapeptidas n-adamantano-sustituidas. |
Country Status (16)
Country | Link |
---|---|
US (1) | US4273704A (es) |
JP (1) | JPS5692847A (es) |
AU (1) | AU6499080A (es) |
BE (1) | BE886472A (es) |
CA (1) | CA1151642A (es) |
DE (1) | DE3044793A1 (es) |
DK (1) | DK513480A (es) |
ES (2) | ES8205753A1 (es) |
FR (1) | FR2476073A1 (es) |
GB (1) | GB2066262B (es) |
IT (1) | IT1127930B (es) |
NL (1) | NL8006586A (es) |
NO (1) | NO803640L (es) |
PT (1) | PT72141B (es) |
SE (1) | SE8008428L (es) |
ZA (1) | ZA807513B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4404135A (en) * | 1981-07-20 | 1983-09-13 | G. D. Searle & Co. | Enkephalin derivatives |
US4407746A (en) * | 1981-12-14 | 1983-10-04 | G. D. Searle & Co. | Cyclohexyl and phenyl substituted enkephalins |
CS231221B1 (en) * | 1982-06-29 | 1984-10-15 | Martin Flegel | L-alanyl-d-isoglutamine adamantylamide |
US4629784A (en) * | 1983-08-16 | 1986-12-16 | The University Of Georgia Research Foundation, Inc. | Synthesis of cyclopropane amino acids |
MX7527E (es) * | 1983-08-16 | 1989-07-25 | Univ Georgia Res Found | Procedimiento para la sintesis de un aminoacido de ciclopropilo |
US4510085A (en) * | 1984-04-12 | 1985-04-09 | G.D. Searle & Co. | Antihypertensive tetrapeptide amides |
US4514332A (en) * | 1984-04-16 | 1985-04-30 | G. D. Searle & Co. | Tetrapeptide adamantyl amides |
FR2572399B1 (fr) * | 1984-10-31 | 1987-01-16 | Panmedica Sa | Nouveaux derives de l'adamantanamine, leurs procedes de preparation et medicaments les contenant |
US4880829A (en) * | 1985-08-14 | 1989-11-14 | G. D. Searle And Company | Substituted dipeptide amides #3 |
US4822775A (en) * | 1986-02-14 | 1989-04-18 | G. D. Searle & Co. | Phenyl substituted dipeptide amides |
US4758675A (en) * | 1986-07-14 | 1988-07-19 | G. D. Searle & Co. | 3-thiophene-substituted tyrosyl dipeptide amides |
US5652335A (en) * | 1990-02-28 | 1997-07-29 | Teikoku Seiyaku Kabushiki Kaisha | Physiologically active substance well capable of permeating biomembrane |
DE69130489T2 (de) * | 1990-02-28 | 1999-05-12 | Teikoku Seiyaku Kk | Physiologisch aktive Substanz die fähig ist Biomembran zu permeieren |
WO1998030329A1 (fr) * | 1997-01-14 | 1998-07-16 | Daicel Chemical Industries, Ltd. | Catalyseurs de nitration ou de carboxylation |
US7795468B2 (en) * | 2001-01-19 | 2010-09-14 | Chevron U.S.A. Inc. | Functionalized higher diamondoids |
US20050261302A1 (en) * | 2004-04-29 | 2005-11-24 | Hoff Ethan D | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application |
US20100222316A1 (en) * | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
US7880001B2 (en) * | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
US20050245534A1 (en) * | 2004-04-29 | 2005-11-03 | Link James T | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
US20080275112A1 (en) * | 2004-07-23 | 2008-11-06 | Schreiner Peter R | Invention Concerning Aminoadamantane Compounds |
CA2585735A1 (en) * | 2004-11-02 | 2006-05-11 | Pfizer Inc. | Novel compounds of substituted and unsubstituted adamantyl amides |
US8198331B2 (en) * | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
BRPI0606256A2 (pt) | 2005-01-05 | 2009-06-09 | Abbott Lab | inibidores da enzima 11-beta-hidroxiesteróide desidrogenase tipo i, uso e composição farmacêutica compreendendo os mesmos |
HRP20050242B1 (en) * | 2005-03-15 | 2010-09-30 | Institut Ruđer Bošković | Synthetic peptides containing unnatural adamantane related amino acids for use as antitumour drugs |
JP5736098B2 (ja) | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
EP2399926A1 (en) * | 2010-06-22 | 2011-12-28 | Justus-Liebig-Universität Giessen | Peptides incorporating 3-aminoadamantane carboxylic acids enhance synaptic plasticity and act as neurogenic agents |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2732451A1 (de) * | 1976-07-27 | 1978-02-02 | Reckitt & Colmann Prod Ltd | Peptidverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate |
-
1979
- 1979-12-03 US US06/099,765 patent/US4273704A/en not_active Expired - Lifetime
-
1980
- 1980-11-28 DE DE19803044793 patent/DE3044793A1/de not_active Withdrawn
- 1980-12-02 NO NO803640A patent/NO803640L/no unknown
- 1980-12-02 ES ES497353A patent/ES8205753A1/es not_active Expired
- 1980-12-02 CA CA000365903A patent/CA1151642A/en not_active Expired
- 1980-12-02 AU AU64990/80A patent/AU6499080A/en not_active Withdrawn
- 1980-12-02 ZA ZA00807513A patent/ZA807513B/xx unknown
- 1980-12-02 SE SE8008428A patent/SE8008428L/ not_active Application Discontinuation
- 1980-12-02 IT IT50294/80A patent/IT1127930B/it active
- 1980-12-02 DK DK513480A patent/DK513480A/da not_active Application Discontinuation
- 1980-12-03 JP JP17078580A patent/JPS5692847A/ja active Pending
- 1980-12-03 FR FR8025696A patent/FR2476073A1/fr not_active Withdrawn
- 1980-12-03 GB GB8038684A patent/GB2066262B/en not_active Expired
- 1980-12-03 BE BE0/203025A patent/BE886472A/fr unknown
- 1980-12-03 PT PT72141A patent/PT72141B/pt unknown
- 1980-12-03 NL NL8006586A patent/NL8006586A/nl not_active Application Discontinuation
-
1981
- 1981-12-16 ES ES508060A patent/ES8300087A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES497353A0 (es) | 1982-06-16 |
AU6499080A (en) | 1981-06-11 |
US4273704A (en) | 1981-06-16 |
SE8008428L (sv) | 1981-06-04 |
ZA807513B (en) | 1982-07-28 |
NL8006586A (nl) | 1981-07-01 |
IT1127930B (it) | 1986-05-28 |
DE3044793A1 (de) | 1981-06-19 |
PT72141B (en) | 1981-10-28 |
CA1151642A (en) | 1983-08-09 |
PT72141A (en) | 1981-01-01 |
BE886472A (fr) | 1981-06-03 |
JPS5692847A (en) | 1981-07-27 |
GB2066262B (en) | 1983-05-11 |
IT8050294A0 (it) | 1980-12-02 |
GB2066262A (en) | 1981-07-08 |
NO803640L (no) | 1981-06-04 |
ES508060A0 (es) | 1982-10-01 |
DK513480A (da) | 1981-07-09 |
ES8300087A1 (es) | 1982-10-01 |
FR2476073A1 (fr) | 1981-08-21 |
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