DE68909362D1 - (2R,3S,4S)-Alpha-(carboxycyclopropyl)glycin. - Google Patents
(2R,3S,4S)-Alpha-(carboxycyclopropyl)glycin.Info
- Publication number
- DE68909362D1 DE68909362D1 DE89119266T DE68909362T DE68909362D1 DE 68909362 D1 DE68909362 D1 DE 68909362D1 DE 89119266 T DE89119266 T DE 89119266T DE 68909362 T DE68909362 T DE 68909362T DE 68909362 D1 DE68909362 D1 DE 68909362D1
- Authority
- DE
- Germany
- Prior art keywords
- carboxycyclopropyl
- glycine
- alpha
- depolarizing
- potent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63261155A JP2757960B2 (ja) | 1988-10-17 | 1988-10-17 | (2R,3S,4S)−α−(カルボキシシクロプロピル)グリシン |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68909362D1 true DE68909362D1 (de) | 1993-10-28 |
DE68909362T2 DE68909362T2 (de) | 1994-03-10 |
Family
ID=17357874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE89119266T Expired - Lifetime DE68909362T2 (de) | 1988-10-17 | 1989-10-17 | (2R,3S,4S)-Alpha-(carboxycyclopropyl)glycin. |
Country Status (6)
Country | Link |
---|---|
US (1) | US5068412A (de) |
EP (1) | EP0363994B1 (de) |
JP (1) | JP2757960B2 (de) |
AT (1) | ATE94867T1 (de) |
DE (1) | DE68909362T2 (de) |
ES (1) | ES2059669T3 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07505908A (ja) * | 1992-09-28 | 1995-06-29 | マックセチーニ、マリア ルイザ | Nmda受容体のアロステリックモジュレーター |
US5717109A (en) * | 1994-09-08 | 1998-02-10 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
NZ291597A (en) * | 1994-09-08 | 1998-12-23 | Lilly Co Eli | Carboxycyclopropan-1-yl derivatives, preparation, pharmaceutical compositions and intermediates thereof |
IT1276153B1 (it) * | 1995-11-17 | 1997-10-27 | Roberto Pellicciari | Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato |
IL124536A (en) * | 1995-12-07 | 2001-03-19 | Daniel C Javitt | Pharmaceutical compositions containing a glycine uptake antagonist |
US6361957B1 (en) | 1999-08-03 | 2002-03-26 | Glytech, Inc. | Assay for D-serine transport antagonist and use for treating psychosis |
US6355681B2 (en) * | 1995-12-07 | 2002-03-12 | Glytech, Inc. | Glycine substitutes and precursors for treating a psychosis |
JPH1053521A (ja) * | 1996-08-12 | 1998-02-24 | Kagaku Gijutsu Shinko Jigyodan | 脳内グルタミン酸の活性抑制剤および活性増強剤 |
US6191306B1 (en) * | 1999-08-03 | 2001-02-20 | Eastman Chemical Company | Process for the preparation of cyclopropylglycine |
US6750364B2 (en) | 2001-06-29 | 2004-06-15 | Wyeth | Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine as inhibitors of glutamate transport |
US6689905B2 (en) | 2001-06-29 | 2004-02-10 | Wyeth | Stereoisomers of 3-aminotricyclo[2.2.1.0(2.6)]heptane-1,3-dicarboxylic acid |
US6689904B2 (en) | 2001-06-29 | 2004-02-10 | Wyeth | Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine |
US7232798B2 (en) * | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
US20100247483A1 (en) * | 2001-11-13 | 2010-09-30 | Tran Loi H | Therapeutic agent composition and method of use |
WO2019222339A1 (en) | 2018-05-15 | 2019-11-21 | Tran Lloyd Hung Loi | Therapeutic agent composition and method of use, for treatment of mild cognitive impairment, depression, and psychological disorders |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1305177C (en) * | 1987-06-30 | 1992-07-14 | Yasufumi Ohfune | Carboxycyclopropylglycine and process for producing the same |
-
1988
- 1988-10-17 JP JP63261155A patent/JP2757960B2/ja not_active Expired - Lifetime
-
1989
- 1989-10-17 US US07/422,796 patent/US5068412A/en not_active Expired - Lifetime
- 1989-10-17 AT AT89119266T patent/ATE94867T1/de not_active IP Right Cessation
- 1989-10-17 ES ES89119266T patent/ES2059669T3/es not_active Expired - Lifetime
- 1989-10-17 DE DE89119266T patent/DE68909362T2/de not_active Expired - Lifetime
- 1989-10-17 EP EP89119266A patent/EP0363994B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE94867T1 (de) | 1993-10-15 |
US5068412A (en) | 1991-11-26 |
ES2059669T3 (es) | 1994-11-16 |
JP2757960B2 (ja) | 1998-05-25 |
JPH02108654A (ja) | 1990-04-20 |
EP0363994A3 (de) | 1991-03-27 |
EP0363994A2 (de) | 1990-04-18 |
DE68909362T2 (de) | 1994-03-10 |
EP0363994B1 (de) | 1993-09-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: SUNTORY HOLDINGS LTD., OSAKA, JP |