IT1276153B1 - Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato - Google Patents

Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato

Info

Publication number
IT1276153B1
IT1276153B1 IT95MI002383A ITMI952383A IT1276153B1 IT 1276153 B1 IT1276153 B1 IT 1276153B1 IT 95MI002383 A IT95MI002383 A IT 95MI002383A IT MI952383 A ITMI952383 A IT MI952383A IT 1276153 B1 IT1276153 B1 IT 1276153B1
Authority
IT
Italy
Prior art keywords
antagonist activity
metabotropic glutamate
glutamate receptors
glycine derivatives
glycine
Prior art date
Application number
IT95MI002383A
Other languages
English (en)
Inventor
Roberto Pellicciari
Flavio Moroni
Original Assignee
Roberto Pellicciari
Flavio Moroni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roberto Pellicciari, Flavio Moroni filed Critical Roberto Pellicciari
Priority to IT95MI002383A priority Critical patent/IT1276153B1/it
Publication of ITMI952383A0 publication Critical patent/ITMI952383A0/it
Priority to AU76274/96A priority patent/AU7627496A/en
Priority to PCT/EP1996/005079 priority patent/WO1997019049A1/en
Publication of ITMI952383A1 publication Critical patent/ITMI952383A1/it
Application granted granted Critical
Publication of IT1276153B1 publication Critical patent/IT1276153B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT95MI002383A 1995-11-17 1995-11-17 Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato IT1276153B1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT95MI002383A IT1276153B1 (it) 1995-11-17 1995-11-17 Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato
AU76274/96A AU7627496A (en) 1995-11-17 1996-11-18 Glycine derivatives
PCT/EP1996/005079 WO1997019049A1 (en) 1995-11-17 1996-11-18 Glycine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI002383A IT1276153B1 (it) 1995-11-17 1995-11-17 Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato

Publications (3)

Publication Number Publication Date
ITMI952383A0 ITMI952383A0 (it) 1995-11-17
ITMI952383A1 ITMI952383A1 (it) 1997-05-17
IT1276153B1 true IT1276153B1 (it) 1997-10-27

Family

ID=11372550

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI002383A IT1276153B1 (it) 1995-11-17 1995-11-17 Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato

Country Status (3)

Country Link
AU (1) AU7627496A (it)
IT (1) IT1276153B1 (it)
WO (1) WO1997019049A1 (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2131463B1 (es) * 1997-04-08 2000-03-01 Lilly Sa Derivados de ciclopropilglicina con propiedades farmaceuticas.
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
JP2002512214A (ja) * 1998-04-17 2002-04-23 ケネス カリー， 代謝生成物産生グルタミン酸レセプターアンタゴニストとしてのキュバン誘導体およびそれらの調製プロセス
WO2000075101A1 (en) 1999-06-03 2000-12-14 Lilly, S.A. Excitatory amino acid receptor modulators
ATE287871T1 (de) 1999-06-03 2005-02-15 Lilly Sa Modulatoren von anregbaren aminosäurerezeptoren
AU2001269821A1 (en) 2000-06-15 2001-12-24 Barbara Chen Cycloalkyl alkanoic acids as integrin receptor antagonists
WO2006087169A1 (en) * 2005-02-15 2006-08-24 Glaxo Group Limited Compounds which potentiate glutamate receptor and uses thereof in medicine
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1305177C (en) * 1987-06-30 1992-07-14 Yasufumi Ohfune Carboxycyclopropylglycine and process for producing the same
JP2757960B2 (ja) * 1988-10-17 1998-05-25 サントリー株式会社 （２Ｒ，３Ｓ，４Ｓ）−α−（カルボキシシクロプロピル）グリシン
JPH03261748A (ja) * 1990-03-09 1991-11-21 Suntory Ltd ３′―位置換ｌ―２（カルボキシシクロプロピル）グリシン類及びその製造法
DE69210214T2 (de) * 1991-10-18 1996-10-02 Suntory Ltd 2-(2,3-dicarboxycyclopropyl)-glycin und ein verfahren zu ihrer herstellung
JP3481975B2 (ja) * 1992-09-08 2003-12-22 サントリー株式会社 （２ｓ，１’ｓ，２’ｒ）−２−（２−カルボキシ−３−置換オキシメチルシクロプロピル）グリシン及びその製造法

Also Published As

Publication number Publication date
ITMI952383A0 (it) 1995-11-17
AU7627496A (en) 1997-06-11
ITMI952383A1 (it) 1997-05-17
WO1997019049A1 (en) 1997-05-29

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Legal Events

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0001 Granted