DE69528843D1 - Pharmakologisch aktive 2-mercaptobenzimidazolderivate - Google Patents

Pharmakologisch aktive 2-mercaptobenzimidazolderivate

Info

Publication number
DE69528843D1
DE69528843D1 DE69528843T DE69528843T DE69528843D1 DE 69528843 D1 DE69528843 D1 DE 69528843D1 DE 69528843 T DE69528843 T DE 69528843T DE 69528843 T DE69528843 T DE 69528843T DE 69528843 D1 DE69528843 D1 DE 69528843D1
Authority
DE
Germany
Prior art keywords
pharmacologically active
mercaptobenzimidazole derivatives
mercaptobenzimidazole
derivatives
pharmacologically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69528843T
Other languages
English (en)
Other versions
DE69528843T2 (de
Inventor
Sergei Borisovich Seredenin
Yuri Alexeevich Blednov
Vladimir Leonidovich Saveliev
Tatyana Yakovlevna Mozhaeva
Eleonora Konstantinovna Orlova
Khagani Sabir Ogly Ragimov
Milada Alnordovna Yarkova
Gennady Georgievich Chichkanov
Natalia Veniaminovna Kaverina
Iosif Borisovich Tsorin
Galina Yurievna Kirsanova
Grigory Georgievich Neznamov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MDR PHARMACEUTICAL LTD.,, LIMASSOL, CY
Original Assignee
NI SKIJ I FARMAKOLOGII AKADEMI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU94022663/04A external-priority patent/RU2061686C1/ru
Priority claimed from RU95106120A external-priority patent/RU2136667C1/ru
Application filed by NI SKIJ I FARMAKOLOGII AKADEMI filed Critical NI SKIJ I FARMAKOLOGII AKADEMI
Publication of DE69528843D1 publication Critical patent/DE69528843D1/de
Application granted granted Critical
Publication of DE69528843T2 publication Critical patent/DE69528843T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69528843T 1994-06-10 1995-05-11 Pharmakologisch aktive 2-mercaptobenzimidazolderivate Expired - Lifetime DE69528843T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU94022663/04A RU2061686C1 (ru) 1994-06-10 1994-06-10 Производные 2-меркаптобензимидазола, обладающие селективной анксиолитической активностью
RU95106120A RU2136667C1 (ru) 1995-04-18 1995-04-18 Производные 2-меркаптобензимидазола, обладающие противоишемической, антиаритмической и противофибрилляторной активностью
PCT/RU1995/000085 WO1995034304A1 (fr) 1994-06-10 1995-05-11 Derives de 2-mercaptobenzimidazole pharmacologiquement actifs

Publications (2)

Publication Number Publication Date
DE69528843D1 true DE69528843D1 (de) 2002-12-19
DE69528843T2 DE69528843T2 (de) 2003-09-18

Family

ID=26653794

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528843T Expired - Lifetime DE69528843T2 (de) 1994-06-10 1995-05-11 Pharmakologisch aktive 2-mercaptobenzimidazolderivate

Country Status (6)

Country Link
US (1) US6376666B1 (de)
EP (1) EP0788795B1 (de)
JP (1) JP3559045B2 (de)
KR (1) KR970703765A (de)
DE (1) DE69528843T2 (de)
WO (1) WO1995034304A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4255138B2 (ja) * 1996-05-24 2009-04-15 湧永製薬株式会社 脳疾患治療剤
DE60007748T2 (de) 1999-06-28 2004-11-25 Fuji Photo Film Co., Ltd., Minami-Ashigara Benzimidazolderivate und sie enthaltende medikamente
EP1201664B1 (de) 1999-06-30 2004-09-08 Fuji Photo Film Co., Ltd. Bemzimidazolverbindungen und medikamente die diese enthalten
US6787561B1 (en) 1999-07-07 2004-09-07 Fuji Photo Film Co., Ltd. Benzimidazole compounds
US6935730B2 (en) * 2000-04-03 2005-08-30 Unicorn Image Products Co. Ltd. Of Zhuhai One-way valve, valve unit assembly, and ink cartridge using the same
US20050243147A1 (en) * 2000-10-12 2005-11-03 Unicorn Image Products Co. Ltd. Ink cartridge having bellows valve, ink filling method and apparatus used thereof
US20060165605A1 (en) 2001-12-28 2006-07-27 Ye-Mon Chen Process to regenerate fcc spent catalyst
WO2010035271A1 (en) * 2008-09-26 2010-04-01 Vascular Dynamics Inc. Devices and methods for control of blood pressure
GB0608899D0 (en) * 2006-05-05 2006-06-14 Leuven K U Res & Dev Novel viral replication inhibitors
EP2423200A1 (de) * 2010-05-26 2012-02-29 Afofarm, Cjsc Polymorphe Formen von 5-ethoxy-2-[2-(morpholin)-ethylthio]benzimidazol-Dihydrochlorid und Herstellungsverfahren dafür
BR102016024814A2 (pt) * 2016-10-24 2018-05-08 Aché Laboratórios Farmacêuticos S.A. composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono
EP4230196A1 (de) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Verbindungen zur verwendung bei der behandlung von dystrophinopathien

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6283M (de) * 1967-03-07 1968-09-02
US4045564A (en) 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
CH642359A5 (en) * 1978-10-02 1984-04-13 Ciba Geigy Ag Benzimidazole derivatives
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation
HU193951B (en) * 1985-03-11 1987-12-28 Richter Gedeon Vegyeszet Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them
US4873346A (en) * 1985-09-20 1989-10-10 The Upjohn Company Substituted benzothiazoles, benzimidazoles, and benzoxazoles
SU1502571A1 (ru) 1987-06-13 1989-08-23 Северо-Западный Заочный Политехнический Институт Способ получени 2-[2-(диалкиламино)-этилтио] бензимидазолов
IT1216522B (it) * 1988-03-25 1990-03-08 Dompe Farmaceutici Spa Derivati alchiltiobenzimidazolici attivi farmacologicamente eprocedimento per la loro preparazione.
JPH06759B2 (ja) 1989-09-22 1994-01-05 ファイザー製薬株式会社 新規なベンゾイミダゾール化合物
JP2524420B2 (ja) * 1990-05-16 1996-08-14 明治製菓株式会社 ピペリジン誘導体及びそれらを有効成分とする抗潰瘍剤
RU2027709C1 (ru) * 1991-06-28 1995-01-27 Научно-исследовательский институт фармакологии РАН Соли 2-[2-(диэтиламино)этилтио] -5,6-диметилбензимидазола, обладающие противоишемической, антигипоксической и антиаритмической активностью и 2-[2-(диэтиламино)этилтио] -5,6-диметилбензимидазол в качестве промежуточного продукта для синтеза солей 2-[2-(диэтиламино)этилтио] -5,6-диметилбензимидазола
US5387600A (en) * 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions

Also Published As

Publication number Publication date
EP0788795B1 (de) 2002-11-13
JP3559045B2 (ja) 2004-08-25
DE69528843T2 (de) 2003-09-18
EP0788795A4 (de) 1998-10-21
KR970703765A (ko) 1997-08-09
EP0788795A1 (de) 1997-08-13
JPH10501550A (ja) 1998-02-10
WO1995034304A1 (fr) 1995-12-21
US6376666B1 (en) 2002-04-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NAUCHNO-ISSLEDOVATELSKY INSTITUT FARMAKOLOGII ROSS

8327 Change in the person/name/address of the patent owner

Owner name: ZAKRYTOE AKTSIONERNOE OBSCHESTVO "MASTERLEK", MOSK

8327 Change in the person/name/address of the patent owner

Owner name: MDR PHARMACEUTICAL LTD.,, LIMASSOL, CY

8328 Change in the person/name/address of the agent

Representative=s name: CABINET HIRSCH & ASSOCIES, PARIS, FR