DE69525418D1 - Benzimidazol-derivate - Google Patents
Benzimidazol-derivateInfo
- Publication number
- DE69525418D1 DE69525418D1 DE69525418T DE69525418T DE69525418D1 DE 69525418 D1 DE69525418 D1 DE 69525418D1 DE 69525418 T DE69525418 T DE 69525418T DE 69525418 T DE69525418 T DE 69525418T DE 69525418 D1 DE69525418 D1 DE 69525418D1
- Authority
- DE
- Germany
- Prior art keywords
- benzimidazole derivatives
- benzimidazole
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11898494 | 1994-05-31 | ||
JP3556295 | 1995-02-23 | ||
JP9052295 | 1995-04-17 | ||
PCT/JP1995/001034 WO1995032960A1 (fr) | 1994-05-31 | 1995-05-30 | Derive de benzimidazol |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69525418D1 true DE69525418D1 (de) | 2002-03-21 |
DE69525418T2 DE69525418T2 (de) | 2002-10-17 |
Family
ID=27288798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69525418T Expired - Fee Related DE69525418T2 (de) | 1994-05-31 | 1995-05-30 | Benzimidazol-derivate |
Country Status (7)
Country | Link |
---|---|
US (1) | US5852011A (de) |
EP (1) | EP0711768B1 (de) |
KR (1) | KR0172649B1 (de) |
CA (1) | CA2168016C (de) |
DE (1) | DE69525418T2 (de) |
ES (1) | ES2172585T3 (de) |
WO (1) | WO1995032960A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5808087A (en) | 1995-11-29 | 1998-09-15 | Mitsui Chemicals, Inc. | Sulfonium salts of pyrrolylbenzimidazoles |
US6137003A (en) * | 1998-10-28 | 2000-10-24 | Shionogi Bioresearch | Bis (haloethyl) aminobenzene derivatives |
HU228466B1 (en) * | 1999-06-23 | 2013-03-28 | Sanofi Aventis Deutschland | Substituted benzimidazole |
DE19948417A1 (de) * | 1999-10-07 | 2001-04-19 | Morphochem Ag | Imidazol-Derivate und ihre Verwendung als Arzneimittel |
TWI225488B (en) * | 1999-12-21 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivatives of homopiperidinyl substituted benzimidazole analogues |
US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
DE60128551D1 (de) | 2000-03-16 | 2007-07-05 | Genesoft Inc | Geladene verbindungen mit einer nukleinsäure-bindenden einheit sowie deren verwendungen |
US7078536B2 (en) * | 2001-03-14 | 2006-07-18 | Genesoft Pharmaceuticals, Inc. | Charged compounds comprising a nucleic acid binding moiety and uses therefor |
WO2002083126A1 (en) | 2001-04-11 | 2002-10-24 | Idenix (Cayman) Limited | Phenylindoles for the treatment of hiv |
US7122626B2 (en) * | 2001-04-26 | 2006-10-17 | Genesoft Pharmceuticals, Inc. | Halogen-substitued thienyl compounds |
US7030150B2 (en) * | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
WO2002101007A2 (en) * | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc | Antipathogenic benzamide compounds |
WO2002100832A1 (en) * | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc. | Isoquinoline compounds having antiinfective activity |
WO2002101073A2 (en) * | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc. | Aryl-benzimidazole compounds having antiinfective activity |
WO2004012736A1 (en) | 2002-08-02 | 2004-02-12 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
EP1545510A4 (de) * | 2002-08-07 | 2006-11-15 | Idenix Cayman Ltd | Substituierte phenylindole zur behandlung von hiv |
WO2004039318A2 (en) * | 2002-10-25 | 2004-05-13 | Genesoft Pharmaceuticals, Inc. | Anti-infective biaryl compounds |
CA2504044A1 (en) * | 2002-11-01 | 2004-05-21 | Merck & Co., Inc. | Carbonylamino-benzimidazole derivatives as androgen receptor modulators |
AU2003294249A1 (en) * | 2002-11-08 | 2004-06-03 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
EP1587529A4 (de) | 2002-12-10 | 2009-08-12 | Oscient Pharmaceuticals Corp | Antibakterielle verbindungen mit(pyrrolcarboxamid)-(benzamid)-(imidazolcarboxamid)-motiv |
TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
WO2005090282A1 (en) * | 2004-03-12 | 2005-09-29 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
JP5031569B2 (ja) | 2004-09-17 | 2012-09-19 | イデニク ファルマセウチカルス インコーポレーテッド | Hiv阻害剤としてのホスホインドール |
EP1836199A1 (de) | 2004-12-30 | 2007-09-26 | Astex Therapeutics Limited | Die aktivität von cdk, gsk und aurora-kinasen modullierende thiazol- und isothiazolderivate |
JP5507049B2 (ja) | 2004-12-30 | 2014-05-28 | アステックス、セラピューティックス、リミテッド | 医薬品 |
WO2006094236A1 (en) * | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N-phenyl benzamide derivatives as sirtuin modulators |
US8088928B2 (en) * | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US20070037865A1 (en) * | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8093401B2 (en) * | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US7855289B2 (en) * | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
WO2007045096A1 (en) * | 2005-10-21 | 2007-04-26 | University Of Saskatchewan | Oligoheteroaromatic luminiscent assemblies as high-affinity dna sequence-directed ligands |
JP5474354B2 (ja) | 2005-12-30 | 2014-04-16 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
WO2008001115A2 (en) | 2006-06-29 | 2008-01-03 | Astex Therapeutics Limited | Pharmaceutical combinations of 1-cyclopropyl-3- [3- (5-m0rphoolin-4-ylmethyl-1h-benzoimidazol-2-yl) -lh-1-pyrazol- 4-yl] -urea |
MX2009003410A (es) * | 2006-09-29 | 2009-07-17 | Idenix Pharmaceuticals Inc | Fosfoindoles enantiomericamente puros como inhibidores de vih. |
CL2008001822A1 (es) * | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras. |
CN101918371A (zh) * | 2007-11-01 | 2010-12-15 | 西特里斯药业公司 | 作为瑟土因调节剂的酰胺衍生物 |
AU2008325148A1 (en) * | 2007-11-08 | 2009-05-14 | Sirtris Pharmaceuticals, Inc. | Solubilized thiazolopyridines |
WO2009158118A2 (en) * | 2008-05-30 | 2009-12-30 | University Of Notre Dame Du Lac | Anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria |
WO2010003048A1 (en) * | 2008-07-03 | 2010-01-07 | Sirtris Pharmaceuticals, Inc. | Benzimidazoles and related analogs as sirtuin modulators |
MX2011006555A (es) | 2008-12-19 | 2011-08-03 | Sirtris Pharmaceuticals Inc | Compuestos de tiazolopiridina moduladores de sirtuina. |
US10314816B2 (en) | 2012-06-08 | 2019-06-11 | Wisconsin Alumni Research Foundation | Antimicrobial compounds, compositions and methods of use thereof |
CN110835333B (zh) * | 2018-08-16 | 2022-10-18 | 中国药科大学 | 苯并咪唑取代唑类化合物及其用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1094903A (en) * | 1964-03-26 | 1967-12-13 | Smith Kline French Lab | Improvements in or relating to nitrofuran derivatives |
US4053472A (en) * | 1969-04-19 | 1977-10-11 | Schering Aktiengesellschaft | 2-(5-nitro-2-imidazolyl)-benzimidazoles |
DE1920635C3 (de) * | 1969-04-19 | 1979-06-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 2-(l-MethyI-5-nitro-2-imidazolyl)benzimidazole |
-
1995
- 1995-05-30 EP EP95919662A patent/EP0711768B1/de not_active Expired - Lifetime
- 1995-05-30 US US08/581,608 patent/US5852011A/en not_active Expired - Fee Related
- 1995-05-30 CA CA002168016A patent/CA2168016C/en not_active Expired - Fee Related
- 1995-05-30 WO PCT/JP1995/001034 patent/WO1995032960A1/ja active IP Right Grant
- 1995-05-30 DE DE69525418T patent/DE69525418T2/de not_active Expired - Fee Related
- 1995-05-30 ES ES95919662T patent/ES2172585T3/es not_active Expired - Lifetime
- 1995-05-31 KR KR1019950014035A patent/KR0172649B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0711768A4 (de) | 1996-09-04 |
KR950032182A (ko) | 1995-12-20 |
WO1995032960A1 (fr) | 1995-12-07 |
EP0711768B1 (de) | 2002-02-13 |
US5852011A (en) | 1998-12-22 |
EP0711768A1 (de) | 1996-05-15 |
DE69525418T2 (de) | 2002-10-17 |
KR0172649B1 (ko) | 1999-02-01 |
CA2168016A1 (en) | 1995-12-07 |
ES2172585T3 (es) | 2002-10-01 |
CA2168016C (en) | 2000-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |