ES2172585T3 - Derivado de benzoimidazol. - Google Patents

Derivado de benzoimidazol.

Info

Publication number
ES2172585T3
ES2172585T3 ES95919662T ES95919662T ES2172585T3 ES 2172585 T3 ES2172585 T3 ES 2172585T3 ES 95919662 T ES95919662 T ES 95919662T ES 95919662 T ES95919662 T ES 95919662T ES 2172585 T3 ES2172585 T3 ES 2172585T3
Authority
ES
Spain
Prior art keywords
benzoimidazol
derived
compounds
novedous
mima
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95919662T
Other languages
English (en)
Inventor
Akio Matsunaga
Yuki Nakajima
Hiroshi Kohno
Hironori Komatsu
Hajime Edatsugi
Daiji Iwata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Inc
Original Assignee
Mitsui Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Application granted granted Critical
Publication of ES2172585T3 publication Critical patent/ES2172585T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE EXPONEN COMPUESTOS REPRESENTADOS POR LA SIGUIENTE FORMULA QUIMICA (I) Y SALES FARMACOLOGICAMENTE ACEPTABLES DE LA MIMA, QUE SON COMPUESTOS NOVEDOSOS UTILES COMO AGENTES ANTICANCERIGENOS, ANTIVIRALES O ANTIMICROBIALES.
ES95919662T 1994-05-31 1995-05-30 Derivado de benzoimidazol. Expired - Lifetime ES2172585T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11898494 1994-05-31
JP3556295 1995-02-23
JP9052295 1995-04-17

Publications (1)

Publication Number Publication Date
ES2172585T3 true ES2172585T3 (es) 2002-10-01

Family

ID=27288798

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95919662T Expired - Lifetime ES2172585T3 (es) 1994-05-31 1995-05-30 Derivado de benzoimidazol.

Country Status (7)

Country Link
US (1) US5852011A (es)
EP (1) EP0711768B1 (es)
KR (1) KR0172649B1 (es)
CA (1) CA2168016C (es)
DE (1) DE69525418T2 (es)
ES (1) ES2172585T3 (es)
WO (1) WO1995032960A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808087A (en) 1995-11-29 1998-09-15 Mitsui Chemicals, Inc. Sulfonium salts of pyrrolylbenzimidazoles
US6137003A (en) * 1998-10-28 2000-10-24 Shionogi Bioresearch Bis (haloethyl) aminobenzene derivatives
PT1194425E (pt) * 1999-06-23 2005-10-31 Aventis Pharma Gmbh Benzimidazoles substituidos
DE19948417A1 (de) * 1999-10-07 2001-04-19 Morphochem Ag Imidazol-Derivate und ihre Verwendung als Arzneimittel
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
JP2003529609A (ja) 2000-03-16 2003-10-07 ジーンソフト インコーポレイティッド 核酸結合部分を含む荷電した化合物およびその利用法
US7078536B2 (en) * 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
AU2002254616B2 (en) 2001-04-11 2007-09-06 Idenix (Cayman) Limited Phenylindoles for the treatment of HIV
US7122626B2 (en) * 2001-04-26 2006-10-17 Genesoft Pharmceuticals, Inc. Halogen-substitued thienyl compounds
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
US6716866B2 (en) * 2001-06-13 2004-04-06 Genesoft Pharmaceuticals, Inc. Aryl-benzimidazole compounds having antiinfective activity
US20030236198A1 (en) * 2001-06-13 2003-12-25 Genesoft, Inc. Antipathogenic benzamide compounds
WO2002100832A1 (en) * 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc. Isoquinoline compounds having antiinfective activity
ATE425753T1 (de) 2002-08-02 2009-04-15 Genesoft Pharmaceuticals Inc Biaryl-verbindungen mit antiinfektiver wirkung
US7365090B2 (en) * 2002-08-07 2008-04-29 Idenix Pharmaceuticals, Inc. Substituted phenylindoles for the treatment of HIV
US7265129B2 (en) * 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
AU2003286757B2 (en) * 2002-11-01 2009-06-04 Merck Sharp & Dohme Corp. Carbonylamino-benzimidazole derivatives as androgen receptor modulators
AU2003294249A1 (en) * 2002-11-08 2004-06-03 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
CA2508769A1 (en) 2002-12-10 2004-06-24 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
TWI372050B (en) 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
WO2005090282A1 (en) * 2004-03-12 2005-09-29 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
US7534809B2 (en) 2004-09-17 2009-05-19 Idenix Pharmaceuticals, Inc. Phospho-indoles as HIV inhibitors
EP1836199A1 (en) 2004-12-30 2007-09-26 Astex Therapeutics Limited Thiazole and isothiazole derivatives that modulate the activity of cdk, gsk and aurora kinases
EP2395000A1 (en) 2004-12-30 2011-12-14 Astex Therapeutics Limited Benzimidazole compounds that modulate the activity of CDK, GSK and aurora kinases
EP1853610A1 (en) * 2005-03-03 2007-11-14 Sirtris Pharmaceuticals, Inc. N-phenyl benzamide derivatives as sirtuin modulators
CA2618370A1 (en) * 2005-08-04 2007-02-15 Sirtris Pharmaceuticals, Inc. Oxazolopyridine derivatives as sirtuin modulators
US8093401B2 (en) * 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7855289B2 (en) * 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US8088928B2 (en) * 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
WO2007045096A1 (en) * 2005-10-21 2007-04-26 University Of Saskatchewan Oligoheteroaromatic luminiscent assemblies as high-affinity dna sequence-directed ligands
WO2007077435A1 (en) 2005-12-30 2007-07-12 Astex Therapeutics Limited Pharmaceutical compounds
WO2008001115A2 (en) 2006-06-29 2008-01-03 Astex Therapeutics Limited Pharmaceutical combinations of 1-cyclopropyl-3- [3- (5-m0rphoolin-4-ylmethyl-1h-benzoimidazol-2-yl) -lh-1-pyrazol- 4-yl] -urea
EA016267B1 (ru) 2006-09-29 2012-03-30 Айденикс Фармасьютикалз, Инк. Энантиомерно чистые фосфоиндолы в качестве ингибиторов hiv
CL2008001822A1 (es) * 2007-06-20 2009-03-13 Sirtris Pharmaceuticals Inc Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras.
WO2009058348A1 (en) * 2007-11-01 2009-05-07 Sirtris Pharmaceuticals, Inc. Amide derivatives as sirtuin modulators
CN101910184A (zh) * 2007-11-08 2010-12-08 西特里斯药业公司 可溶性噻唑并吡啶
WO2009158118A2 (en) * 2008-05-30 2009-12-30 University Of Notre Dame Du Lac Anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria
AU2009266889B2 (en) * 2008-07-03 2013-05-02 Glaxosmithkline Llc Benzimidazoles and related analogs as sirtuin modulators
JP5628828B2 (ja) 2008-12-19 2014-11-19 サートリス ファーマシューティカルズ， インコーポレイテッド チアゾロピリジンサーチュイン調節化合物
WO2013185124A1 (en) * 2012-06-08 2013-12-12 Wisconsin Alumni Research Foundation Antimicrobial compounds, compositions and methods of use thereof
CN110835333B (zh) * 2018-08-16 2022-10-18 中国药科大学 苯并咪唑取代唑类化合物及其用途
MX2021012690A (es) 2019-04-19 2022-01-31 Ligand Pharm Inc Formas cristalinas y metodos para producir formas cristalinas de un compuesto.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1094903A (en) * 1964-03-26 1967-12-13 Smith Kline French Lab Improvements in or relating to nitrofuran derivatives
US4053472A (en) * 1969-04-19 1977-10-11 Schering Aktiengesellschaft 2-(5-nitro-2-imidazolyl)-benzimidazoles
DE1920635C3 (de) * 1969-04-19 1979-06-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen 2-(l-MethyI-5-nitro-2-imidazolyl)benzimidazole

Also Published As

Publication number Publication date
DE69525418T2 (de) 2002-10-17
WO1995032960A1 (en) 1995-12-07
CA2168016C (en) 2000-09-26
CA2168016A1 (en) 1995-12-07
KR950032182A (ko) 1995-12-20
EP0711768B1 (en) 2002-02-13
DE69525418D1 (de) 2002-03-21
US5852011A (en) 1998-12-22
KR0172649B1 (ko) 1999-02-01
EP0711768A4 (en) 1996-09-04
EP0711768A1 (en) 1996-05-15

Similar Documents

Publication Publication Date Title
ES2172585T3 (es) Derivado de benzoimidazol.
BR0115452A (pt) Compostos tendo atividade fungicida e processos para fabricação e uso dos mesmos
NO2022019I1 (no) Eribulin eller et farmasøytisk akseptabelt salt derav - forlenget SPC
PT750618E (pt) Derivados de oxazolidinona e composicoes farmaceuticas que os contem
ES2179071T3 (es) Agentes vasodilatadores perifericos que comprenden como principio activo derivados de la piperidina 4-amino n-acilada.
ECSP045139A (es) DERIVADOS DE ACETILENO QUE TIENEN ACTIVIDAD ANTAGONISTICA DE MGluR5
BR0213010A (pt) Aminopirimidinas substituìdas com tiazolila como agentes de proteção de plantas
BR9005343A (pt) Derivado de triazina,e herbicida que o contem como ingrediente ativo
PT976760E (pt) Oligopeptidos com actividade fungicida
BR0313420A (pt) Quinolonas microbicidas, suas composições e usos
BR9107049A (pt) Aril-haloquirazois substituidos herbicidas
ATE303993T1 (de) 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe
DK1200418T3 (da) Nematodicide trifluorbutener
TR200102705T2 (tr) Sinerjistik insektisit karışımları
GT199900067A (es) Nuevas 4-fenilpiperidinas para el tratamiento dedermatosis prurìtica.
ES2104015T3 (es) Derivado del acido metoxiiminoacetico y fungicida agricola/horticola que lo contiene como ingrediente activo.
PT718293E (pt) Composto ciclodepsipeptidico
CO4650121A1 (es) Dihidropiridazinonas y piridazinonas y su uso como fungici- das e insecticidas
NO20014925L (no) Farmasöytiske forbindelser
ATE299871T1 (de) Neue zyklische depsipeptid pf1022 derivate
DE69921151D1 (de) Fluorszierende marker
PT1027348E (pt) 2-(2'-hidroxifenil)-benzotriazois utilizados como agentes estabilizadores da luz ultravioleta
ES2151168T3 (es) N-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas.
ES2011427T3 (es) Derivados de la oxima de octahidronaftaleno para la inhibicion de la sintesis del colesterol, procedimientos para su preparacion y composiciones que los contienen.
ATE274904T1 (de) 4,5-dihydroxy-2-cyclopenten-1-on für die behandlung von diabetes mellitus

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 711768

Country of ref document: ES