DE69841086D1 - 5-Deoxy-Cytidin-Derivate - Google Patents

5-Deoxy-Cytidin-Derivate

Info

Publication number
DE69841086D1
DE69841086D1 DE69841086T DE69841086T DE69841086D1 DE 69841086 D1 DE69841086 D1 DE 69841086D1 DE 69841086 T DE69841086 T DE 69841086T DE 69841086 T DE69841086 T DE 69841086T DE 69841086 D1 DE69841086 D1 DE 69841086D1
Authority
DE
Germany
Prior art keywords
deoxy
cytidine derivatives
cytidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69841086T
Other languages
English (en)
Inventor
Kazuo Hattori
Tohru Ishikawa
Hideo Ishitsuka
Yasunori Kohchi
Nobuhiro Oikawa
Nobuo Shimma
Hitomi Suda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69841086D1 publication Critical patent/DE69841086D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69841086T 1997-06-02 1998-05-22 5-Deoxy-Cytidin-Derivate Expired - Lifetime DE69841086D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97108791 1997-06-02

Publications (1)

Publication Number Publication Date
DE69841086D1 true DE69841086D1 (de) 2009-10-08

Family

ID=8226859

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69841086T Expired - Lifetime DE69841086D1 (de) 1997-06-02 1998-05-22 5-Deoxy-Cytidin-Derivate
DE19823484A Ceased DE19823484A1 (de) 1997-06-02 1998-05-26 5'-Desoxycytidin-derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19823484A Ceased DE19823484A1 (de) 1997-06-02 1998-05-26 5'-Desoxycytidin-derivate

Country Status (33)

Country Link
US (2) US6114520A (de)
JP (1) JP3081185B2 (de)
KR (1) KR100312899B1 (de)
CN (1) CN1197871C (de)
AR (1) AR012878A1 (de)
AT (1) ATE440854T1 (de)
AU (1) AU746170B2 (de)
BR (1) BR9801744A (de)
CA (1) CA2237368C (de)
CO (1) CO4940436A1 (de)
CZ (1) CZ295706B6 (de)
DE (2) DE69841086D1 (de)
ES (2) ES2329428T3 (de)
FR (1) FR2763953B1 (de)
GB (1) GB2325931B (de)
HR (1) HRP980290A2 (de)
HU (1) HU227852B1 (de)
ID (1) ID19801A (de)
IL (1) IL124661A0 (de)
IT (1) ITMI981196A1 (de)
MA (1) MA26503A1 (de)
MY (1) MY128985A (de)
NO (1) NO316609B1 (de)
NZ (1) NZ330360A (de)
PE (1) PE79599A1 (de)
PL (1) PL192832B1 (de)
RS (1) RS50010B (de)
RU (1) RU2238278C2 (de)
SA (1) SA98190103B1 (de)
SG (1) SG66466A1 (de)
TR (1) TR199800988A2 (de)
TW (1) TW584636B (de)
ZA (1) ZA984478B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119724A1 (en) * 1995-11-22 2003-06-26 Ts`O Paul O.P. Ligands to enhance cellular uptake of biomolecules
DK1057831T3 (da) * 1999-05-26 2005-01-31 Hoffmann La Roche Fremgangsmåde til fremstilling af vinylpyrimidinderivater
CN100406065C (zh) 2000-12-01 2008-07-30 细胞工厂治疗公司 糖基化/半乳糖基化肽、双官能接头和核苷酸单体/多聚体的缀合物以及相关的组合物和使用方法
US8318756B2 (en) * 2004-12-03 2012-11-27 Adherex Technologies, Inc. Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
US8741858B2 (en) 2007-09-21 2014-06-03 Zhongxu Ren Oligomer-nucleoside phosphate conjugates
CN101469008B (zh) * 2007-12-29 2013-08-07 上海特化医药科技有限公司 卡培他滨羟基衍生物、其制备方法和用于制备卡培他滨
WO2009082846A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
WO2009082844A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
WO2009094847A1 (fr) * 2007-12-28 2009-08-06 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de capécitabine, procédés de préparation et d' utilisation de la capécitabine
DK2276774T3 (en) 2008-03-14 2016-11-28 Retrotope Inc Drugs that modulate genome methylation.
EP2393472B1 (de) * 2008-12-05 2019-06-05 NanoMed Holdings Pty Ltd Amphiphile prodrugs
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
EP2488182B1 (de) * 2009-10-14 2017-07-19 Elion Oncology LLC Behandlung von Neurotoxizität assoziert mit Kombinationen aus 5-FU oder Prodrugs davon und DPD-Hemmer
CN104926890B (zh) * 2015-06-04 2018-04-03 新乡学院 一种1,2‑o‑二乙酰基‑3,5‑o‑二苯甲酰基核糖的合成方法
JP2021512953A (ja) 2018-02-02 2021-05-20 メイベリックス オンコロジー インコーポレイテッド ゲムシタビンモノホスフェートの小分子薬物コンジュゲート
CN113321694A (zh) * 2021-06-22 2021-08-31 药康众拓(江苏)医药科技有限公司 N4-羟基胞苷衍生物及其制备方法和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726278B2 (de) * 1973-03-13 1982-06-03
GB1561290A (en) * 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
US4071680A (en) * 1976-12-20 1978-01-31 Hoffmann-La Roche Inc. 5'-Deoxy-5-fluoropyrimidine nucleosides
CH633810A5 (en) * 1978-01-01 1982-12-31 Hoffmann La Roche Novel nucleosides and process for their preparation
US4328229A (en) * 1978-03-29 1982-05-04 Taiho Pharmaceutical Company Limited Anti-cancer composition for delivering 5-fluorouracil to cancer tissues
JPS5677226A (en) * 1979-11-27 1981-06-25 Taiho Yakuhin Kogyo Kk Antitumorigenic agent
EP0160079B1 (de) * 1983-10-26 1990-01-31 GREER, Sheldon B. Verfahren und materialien zum empfindlichmachen eines neoplastischen gewebes vor strahlung
US5736531A (en) * 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
GB9020930D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
EP0543015B1 (de) * 1991-05-27 1998-11-11 Taiho Pharmaceutical Co., Ltd. Zusammensetzung, verfahren und instrument zur potenzierung der antitumoraktivität und zur behandlung von tumoren
DE4123520A1 (de) * 1991-07-16 1993-01-21 Inst Molekularbiologie Ak Mittel zur regeneration des blutbildes durch foerderung der leukozytenproliferation
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
TW254946B (de) * 1992-12-18 1995-08-21 Hoffmann La Roche
AU6081294A (en) * 1993-05-14 1994-12-12 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
CA2170608C (en) * 1993-09-14 1999-03-30 James R. Mccarthy 5-(1-fluoro-vinyl)-1h-pyrimidine-2,4-dione derivatives useful as antineoplastic agents
US5476932A (en) * 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
AU5998296A (en) * 1995-05-26 1996-12-11 F. Hoffmann-La Roche Ag Compositions of interleukin and pyrimidine nucleosides

Also Published As

Publication number Publication date
PL192832B1 (pl) 2006-12-29
FR2763953A1 (fr) 1998-12-04
ITMI981196A1 (it) 1999-11-29
AU746170B2 (en) 2002-04-18
AR012878A1 (es) 2000-11-22
SA98190103B1 (ar) 2006-04-18
CN1201037A (zh) 1998-12-09
CA2237368A1 (en) 1998-12-02
NO982473L (no) 1998-12-03
US6114520A (en) 2000-09-05
ES2329428T3 (es) 2009-11-25
HU227852B1 (en) 2012-05-02
ID19801A (id) 1998-08-06
CN1197871C (zh) 2005-04-20
BR9801744A (pt) 2000-03-21
CZ295706B6 (cs) 2005-10-12
PE79599A1 (es) 1999-08-25
RU2238278C2 (ru) 2004-10-20
GB9811762D0 (en) 1998-07-29
IL124661A0 (en) 1998-12-06
SG66466A1 (en) 1999-07-20
ATE440854T1 (de) 2009-09-15
HRP980290A2 (en) 1999-04-30
ES2142763B1 (es) 2001-04-01
HU9801256D0 (en) 1998-07-28
TR199800988A3 (tr) 1998-12-21
CO4940436A1 (es) 2000-07-24
TR199800988A2 (xx) 1998-12-21
JPH10330395A (ja) 1998-12-15
KR19990006547A (ko) 1999-01-25
DE19823484A1 (de) 1998-12-03
PL326604A1 (en) 1998-12-07
KR100312899B1 (ko) 2002-03-08
NO982473D0 (no) 1998-05-29
HUP9801256A2 (hu) 1999-05-28
AU6798598A (en) 1998-12-03
CA2237368C (en) 2009-03-03
YU22598A (sh) 2001-12-26
ZA984478B (en) 1998-12-02
HUP9801256A3 (en) 2004-03-01
GB2325931A (en) 1998-12-09
RS50010B (sr) 2008-09-29
NZ330360A (en) 1999-03-29
NO316609B1 (no) 2004-03-08
GB2325931B (en) 2001-07-25
MY128985A (en) 2007-03-30
JP3081185B2 (ja) 2000-08-28
CZ167598A3 (cs) 1998-12-16
FR2763953B1 (fr) 2005-01-07
ES2142763A1 (es) 2000-04-16
US6211166B1 (en) 2001-04-03
TW584636B (en) 2004-04-21
MA26503A1 (fr) 2004-12-20

Similar Documents

Publication Publication Date Title
ATE260243T1 (de) N-aroylphenylalaninderivate
ATE235220T1 (de) Resorcinderivate
ID22781A (id) Turunan-turunan nikotinamida
DE69817186D1 (de) Diaminorhodamin-derivate
ATE323682T1 (de) Aryl-pyrimidin-derivate
DK0891332T3 (da) 6-phenylpyridyl-2-aminderivater
ATA93198A (de) Fluoxetinpellets
PT915088E (pt) Derivados de d-prolina
NO981946D0 (no) Imidazoquinazolin-derivater
ATE255098T1 (de) Substituierte chromanderivate
DE69732576D1 (de) Tetrahydrobenzindolon-derivate
PT1003719E (pt) Derivados microbicidas de n-sulfonil-glicinalquiniloxifenemetilamida
PT1027362E (pt) Derivados de cetolidos 2-halogeno-6-o-substituidos
DE69841086D1 (de) 5-Deoxy-Cytidin-Derivate
ATE255099T1 (de) Substituierte chromanderivate
IS5026A (is) 2-metoxýfenýlpíperasín afleiður
DE69829682D1 (de) Cis-disubstituierte aminocycloalkyl-pyrrolidin-derivate
DE69828780D1 (de) Amidinocamptpthecin-derivate
NO981495D0 (no) Phenoxymetylpiperidin-derivater
DK0966437T3 (da) 5-Aroylnaphthalenderivater
ATA111897A (de) Kimme
ATE236897T1 (de) 3-benzylpiperidine
ATA112597A (de) Snowboard - bindung
DK1015447T3 (da) Piperidinylmethyloxazolidinonderivat
ATA86797A (de) Verschleissschuh

Legal Events

Date Code Title Description
8364 No opposition during term of opposition