JPS5677226A - Antitumorigenic agent - Google Patents
Antitumorigenic agentInfo
- Publication number
- JPS5677226A JPS5677226A JP15383479A JP15383479A JPS5677226A JP S5677226 A JPS5677226 A JP S5677226A JP 15383479 A JP15383479 A JP 15383479A JP 15383479 A JP15383479 A JP 15383479A JP S5677226 A JPS5677226 A JP S5677226A
- Authority
- JP
- Japan
- Prior art keywords
- antitumorigenic
- fluoropyrimidine
- agent
- deoxy
- uracil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: An antitumorigenic agent that contains a 5-fluoropyrimidine, thus showing increased antitumorigenic activity and reduced toxicity.
CONSTITUTION: The antitumorigenic agent contains a 5-fluoropyrimidine selected from 5'-deoxy-5-fluorouridine or 5'-deoxy-5-fluorocytidine and a uracyl selected from uracil, thymine and thymidine, preferably at a ratio of 1mol of the former to 0.5mol or more of the latter. A uracil itself does not show antitumorigenic effect, however, the addition of this compound remarkably increases the antitumorigenic effect of 5-fluoropyrimidine (6 times in an example). Further, no acute toxicity is observed even when the maximum dose that is technically possible in an experiment is administered.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15383479A JPS5677226A (en) | 1979-11-27 | 1979-11-27 | Antitumorigenic agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15383479A JPS5677226A (en) | 1979-11-27 | 1979-11-27 | Antitumorigenic agent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5677226A true JPS5677226A (en) | 1981-06-25 |
JPS621371B2 JPS621371B2 (en) | 1987-01-13 |
Family
ID=15571104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15383479A Granted JPS5677226A (en) | 1979-11-27 | 1979-11-27 | Antitumorigenic agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5677226A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6114520A (en) * | 1997-06-02 | 2000-09-05 | Hoffmann-La Roche Inc. | 5'-deoxy-cytidine derivatives |
-
1979
- 1979-11-27 JP JP15383479A patent/JPS5677226A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6114520A (en) * | 1997-06-02 | 2000-09-05 | Hoffmann-La Roche Inc. | 5'-deoxy-cytidine derivatives |
US6211166B1 (en) * | 1997-06-02 | 2001-04-03 | Hoffman-La Roche Inc. | 5′-deoxy-cytidine derivative administration to treat solid tumors |
Also Published As
Publication number | Publication date |
---|---|
JPS621371B2 (en) | 1987-01-13 |
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