JPS5677226A - Antitumorigenic agent - Google Patents

Antitumorigenic agent

Info

Publication number
JPS5677226A
JPS5677226A JP15383479A JP15383479A JPS5677226A JP S5677226 A JPS5677226 A JP S5677226A JP 15383479 A JP15383479 A JP 15383479A JP 15383479 A JP15383479 A JP 15383479A JP S5677226 A JPS5677226 A JP S5677226A
Authority
JP
Japan
Prior art keywords
antitumorigenic
fluoropyrimidine
agent
deoxy
uracil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15383479A
Other languages
Japanese (ja)
Other versions
JPS621371B2 (en
Inventor
Norio Saimi
Setsuo Takeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP15383479A priority Critical patent/JPS5677226A/en
Publication of JPS5677226A publication Critical patent/JPS5677226A/en
Publication of JPS621371B2 publication Critical patent/JPS621371B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: An antitumorigenic agent that contains a 5-fluoropyrimidine, thus showing increased antitumorigenic activity and reduced toxicity.
CONSTITUTION: The antitumorigenic agent contains a 5-fluoropyrimidine selected from 5'-deoxy-5-fluorouridine or 5'-deoxy-5-fluorocytidine and a uracyl selected from uracil, thymine and thymidine, preferably at a ratio of 1mol of the former to 0.5mol or more of the latter. A uracil itself does not show antitumorigenic effect, however, the addition of this compound remarkably increases the antitumorigenic effect of 5-fluoropyrimidine (6 times in an example). Further, no acute toxicity is observed even when the maximum dose that is technically possible in an experiment is administered.
COPYRIGHT: (C)1981,JPO&Japio
JP15383479A 1979-11-27 1979-11-27 Antitumorigenic agent Granted JPS5677226A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15383479A JPS5677226A (en) 1979-11-27 1979-11-27 Antitumorigenic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15383479A JPS5677226A (en) 1979-11-27 1979-11-27 Antitumorigenic agent

Publications (2)

Publication Number Publication Date
JPS5677226A true JPS5677226A (en) 1981-06-25
JPS621371B2 JPS621371B2 (en) 1987-01-13

Family

ID=15571104

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15383479A Granted JPS5677226A (en) 1979-11-27 1979-11-27 Antitumorigenic agent

Country Status (1)

Country Link
JP (1) JPS5677226A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114520A (en) * 1997-06-02 2000-09-05 Hoffmann-La Roche Inc. 5'-deoxy-cytidine derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114520A (en) * 1997-06-02 2000-09-05 Hoffmann-La Roche Inc. 5'-deoxy-cytidine derivatives
US6211166B1 (en) * 1997-06-02 2001-04-03 Hoffman-La Roche Inc. 5′-deoxy-cytidine derivative administration to treat solid tumors

Also Published As

Publication number Publication date
JPS621371B2 (en) 1987-01-13

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