JPS55111420A - Antitumorigenic agent - Google Patents

Antitumorigenic agent

Info

Publication number
JPS55111420A
JPS55111420A JP1793479A JP1793479A JPS55111420A JP S55111420 A JPS55111420 A JP S55111420A JP 1793479 A JP1793479 A JP 1793479A JP 1793479 A JP1793479 A JP 1793479A JP S55111420 A JPS55111420 A JP S55111420A
Authority
JP
Japan
Prior art keywords
fluorouracil
compounds
formula
antitumorigenic
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1793479A
Other languages
Japanese (ja)
Other versions
JPS6337766B2 (en
Inventor
Setsuo Fujii
Yoshinori Sakai
Yutaro Sasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP1793479A priority Critical patent/JPS55111420A/en
Publication of JPS55111420A publication Critical patent/JPS55111420A/en
Publication of JPS6337766B2 publication Critical patent/JPS6337766B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: An antitumorigenic agent that is made by combining a 5-fluorouracil with a specific compound, thus showing increased effectiveness.
CONSTITUTION: Said antitumorigenic agent contains a 5-fluorouracil selected from compounds of formula I (R1, R2 are H, halogen, alkyl), e.g., 5-fluorouracil, and compounds of formula II (R3, R4 are H, alkyl, aryl) and a combining agent selected from compounds of formula III, IV and V (R5, R6 are H, Cl, cyano, amino; R7, R8 are H, halogen, alkyl, aryl) and compounds of formula VI (R9, R10 are H, halogen, carboxyl), e.g., N1-methyluracil, or N1, N3-dimethylthymine, as effective components. These combinations show more excellent antitumorigenic activity and toxic properties than the combination of 5-fluorouracil and uracil and N1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) alone.
COPYRIGHT: (C)1980,JPO&Japio
JP1793479A 1979-02-20 1979-02-20 Antitumorigenic agent Granted JPS55111420A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1793479A JPS55111420A (en) 1979-02-20 1979-02-20 Antitumorigenic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1793479A JPS55111420A (en) 1979-02-20 1979-02-20 Antitumorigenic agent

Publications (2)

Publication Number Publication Date
JPS55111420A true JPS55111420A (en) 1980-08-28
JPS6337766B2 JPS6337766B2 (en) 1988-07-27

Family

ID=11957595

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1793479A Granted JPS55111420A (en) 1979-02-20 1979-02-20 Antitumorigenic agent

Country Status (1)

Country Link
JP (1) JPS55111420A (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60184066A (en) * 1984-03-02 1985-09-19 Sagami Chem Res Center 5-fluoro-6-chlorouracil derivative and its preparation
JPS60199881A (en) * 1984-03-23 1985-10-09 Nippon Kasei Kk 5-fluorouracil derivative and its preparation
WO1990007334A1 (en) * 1989-01-05 1990-07-12 Otsuka Pharmaceutical Co., Ltd. Non-injection carcinostatic agent for suppressing occurrence of inflammation due to 5-fluorouracil and method for curing cancer
US5034528A (en) * 1988-07-27 1991-07-23 North Carolina Central University Compositions for the control of hyperlipidemia
WO1992021345A1 (en) * 1991-05-27 1992-12-10 Taiho Pharmaceutical Co., Ltd. Composition, method and kit for potentiating antitumor activity and for curing tumor
EP0985415A1 (en) * 1990-09-26 2000-03-15 The Wellcome Foundation Limited Uracil reductase inactivators
JP2009113837A (en) * 2007-11-06 2009-05-28 Zojirushi Corp Container for beverage with cover
CN102659689A (en) * 2012-05-16 2012-09-12 浙江工业大学 4-substituted-2-butoxy-5-fluoropyrimidine compounds, and preparation method and application thereof
JP2014208692A (en) * 2008-12-09 2014-11-06 ギリアード サイエンシーズ， インコーポレイテッド Modulator of toll-like receptor
US10202384B2 (en) 2014-09-16 2019-02-12 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
US11116774B2 (en) 2014-07-11 2021-09-14 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of HIV

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5335834A (en) * 1976-09-13 1978-04-03 Yoshinobu Watanabe Hydraulic pressure machine for power generation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5335834A (en) * 1976-09-13 1978-04-03 Yoshinobu Watanabe Hydraulic pressure machine for power generation

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60184066A (en) * 1984-03-02 1985-09-19 Sagami Chem Res Center 5-fluoro-6-chlorouracil derivative and its preparation
JPS60199881A (en) * 1984-03-23 1985-10-09 Nippon Kasei Kk 5-fluorouracil derivative and its preparation
US5034528A (en) * 1988-07-27 1991-07-23 North Carolina Central University Compositions for the control of hyperlipidemia
WO1990007334A1 (en) * 1989-01-05 1990-07-12 Otsuka Pharmaceutical Co., Ltd. Non-injection carcinostatic agent for suppressing occurrence of inflammation due to 5-fluorouracil and method for curing cancer
EP0985415A1 (en) * 1990-09-26 2000-03-15 The Wellcome Foundation Limited Uracil reductase inactivators
WO1992021345A1 (en) * 1991-05-27 1992-12-10 Taiho Pharmaceutical Co., Ltd. Composition, method and kit for potentiating antitumor activity and for curing tumor
US5525603A (en) * 1991-05-27 1996-06-11 Taiho Pharmaceutical Co., Ltd. Compositions, methods and kits for potentiating antitumor effect and for treating tumor
JP2009113837A (en) * 2007-11-06 2009-05-28 Zojirushi Corp Container for beverage with cover
US11110091B2 (en) 2008-12-09 2021-09-07 Gilead Sciences, Inc. Modulators of toll-like receptors
JP2014208692A (en) * 2008-12-09 2014-11-06 ギリアード サイエンシーズ， インコーポレイテッド Modulator of toll-like receptor
US9452166B2 (en) 2008-12-09 2016-09-27 Gilead Sciences, Inc. Modulators of toll-like receptors
US10172860B2 (en) 2008-12-09 2019-01-08 Gilead Sciences, Inc. Modulators of toll-like receptors
CN102659689A (en) * 2012-05-16 2012-09-12 浙江工业大学 4-substituted-2-butoxy-5-fluoropyrimidine compounds, and preparation method and application thereof
US11116774B2 (en) 2014-07-11 2021-09-14 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of HIV
US10508117B2 (en) 2014-09-16 2019-12-17 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
US11072615B2 (en) 2014-09-16 2021-07-27 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
US10202384B2 (en) 2014-09-16 2019-02-12 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
US11773098B2 (en) 2014-09-16 2023-10-03 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator

Also Published As

Publication number Publication date
JPS6337766B2 (en) 1988-07-27

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees