JPS5683420A - Antineoplasmic composition - Google Patents
Antineoplasmic compositionInfo
- Publication number
- JPS5683420A JPS5683420A JP16109179A JP16109179A JPS5683420A JP S5683420 A JPS5683420 A JP S5683420A JP 16109179 A JP16109179 A JP 16109179A JP 16109179 A JP16109179 A JP 16109179A JP S5683420 A JPS5683420 A JP S5683420A
- Authority
- JP
- Japan
- Prior art keywords
- antineoplasmic
- fluorouracil
- uracil
- composition
- reduced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To prepare an antineoplasmic composition having increased antineoplasmic activity and reduced toxicity, by combining 3-fluorouracils with a large amount of uracil.
CONSTITUTION: 1mol of uracil or its salt is mixed with a small amount (<0.1mol, usually 0.01W0.1mol) of a 5-fluorouracil derivative of formula (R1 and R2 are H, tetrahydrofuryl, alkoxymethyl, or alkylcarbamoyl), e.g. 1-(2-tetrahydrofuryl)-5- fluorouracil. The antineoplasmic activity of the 5-fluorouracil is increased by adding a large amount of uracil which has no antineoplasmic activity. Or the amount of the 5-fluorouracil can be reduced to attain the same antineoplasmic effect, and consequently the toxicity can also be reduced.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16109179A JPS5683420A (en) | 1979-12-11 | 1979-12-11 | Antineoplasmic composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16109179A JPS5683420A (en) | 1979-12-11 | 1979-12-11 | Antineoplasmic composition |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5683420A true JPS5683420A (en) | 1981-07-08 |
JPS6213924B2 JPS6213924B2 (en) | 1987-03-30 |
Family
ID=15728432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16109179A Granted JPS5683420A (en) | 1979-12-11 | 1979-12-11 | Antineoplasmic composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5683420A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60199881A (en) * | 1984-03-23 | 1985-10-09 | Nippon Kasei Kk | 5-fluorouracil derivative and its preparation |
EP0597130A1 (en) * | 1992-05-01 | 1994-05-18 | Dott Limited Company | Antirheumatic |
-
1979
- 1979-12-11 JP JP16109179A patent/JPS5683420A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60199881A (en) * | 1984-03-23 | 1985-10-09 | Nippon Kasei Kk | 5-fluorouracil derivative and its preparation |
EP0597130A1 (en) * | 1992-05-01 | 1994-05-18 | Dott Limited Company | Antirheumatic |
EP0597130A4 (en) * | 1992-05-01 | 1994-06-01 | Dott Ltd Comp | Antirheumatic. |
Also Published As
Publication number | Publication date |
---|---|
JPS6213924B2 (en) | 1987-03-30 |
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