JPS5564518A - Carcinostatic composition - Google Patents

Carcinostatic composition

Info

Publication number
JPS5564518A
JPS5564518A JP13768678A JP13768678A JPS5564518A JP S5564518 A JPS5564518 A JP S5564518A JP 13768678 A JP13768678 A JP 13768678A JP 13768678 A JP13768678 A JP 13768678A JP S5564518 A JPS5564518 A JP S5564518A
Authority
JP
Japan
Prior art keywords
thymidine
preparation containing
fluorouracil
mole
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13768678A
Other languages
Japanese (ja)
Other versions
JPS6223725B2 (en
Inventor
Setsuo Fujii
Norio Saimi
Setsuo Takeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP13768678A priority Critical patent/JPS5564518A/en
Priority to GB7908960A priority patent/GB2016921B/en
Priority to CH272679A priority patent/CH639274A5/en
Priority to FR7907523A priority patent/FR2420974A1/en
Priority to DE2912112A priority patent/DE2912112C2/en
Priority to IT67629/79A priority patent/IT1119283B/en
Publication of JPS5564518A publication Critical patent/JPS5564518A/en
Priority to US06/552,263 priority patent/US4650801A/en
Priority to US06/932,516 priority patent/US4914105A/en
Publication of JPS6223725B2 publication Critical patent/JPS6223725B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: 5-Fluorouracil and thymidine are used as the effective ingredients to produce title composition with improved balance between the effectiveness and the side effects.
CONSTITUTION: At least one of 5-fluorouracils selected from the compounds of the formula (R1 and R2 are H, alkoxymethyl, tetrahydrofurfuryl, alkylcarbamoyl) and thymidine are added in a proportion of 1 mole of the former and over 0.5 mole of the latter and they are prepared to an oral preparation containing 20W1200mg/d of 5-fluorouracil, injection preparation containing 50W2000mg/d, and suppository preparation containing 250W2000mg/d. Although thymidine itself does not have carcinostatice activity, the combination remarkably increases the effect to give said carcinostatic composition with extremely increased LD50/ED50.
COPYRIGHT: (C)1980,JPO&Japio
JP13768678A 1978-03-27 1978-11-07 Carcinostatic composition Granted JPS5564518A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP13768678A JPS5564518A (en) 1978-11-07 1978-11-07 Carcinostatic composition
GB7908960A GB2016921B (en) 1978-03-27 1979-03-14 Anti cancer compositions containing uracil derivatives
CH272679A CH639274A5 (en) 1978-03-27 1979-03-23 ANTI-DRINKING AGENTS.
FR7907523A FR2420974A1 (en) 1978-03-27 1979-03-26 MEDICINE BASED ON URACIL DERIVATIVES
DE2912112A DE2912112C2 (en) 1978-03-27 1979-03-27 Anti-cancer drug
IT67629/79A IT1119283B (en) 1978-03-27 1979-03-27 ANTI-CANCER COMPOSITION
US06/552,263 US4650801A (en) 1978-03-27 1983-11-16 Anti-cancer compositions for delivering 5-fluorouracil
US06/932,516 US4914105A (en) 1978-03-27 1986-11-20 Anti-cancer compositions for delivering 5-fluorouracil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13768678A JPS5564518A (en) 1978-11-07 1978-11-07 Carcinostatic composition

Publications (2)

Publication Number Publication Date
JPS5564518A true JPS5564518A (en) 1980-05-15
JPS6223725B2 JPS6223725B2 (en) 1987-05-25

Family

ID=15204428

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13768678A Granted JPS5564518A (en) 1978-03-27 1978-11-07 Carcinostatic composition

Country Status (1)

Country Link
JP (1) JPS5564518A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0997473B1 (en) * 1997-06-03 2003-04-09 ITOCHU Techno-Chemical Inc. Natural antitumor or antiviral substances and use of the same

Also Published As

Publication number Publication date
JPS6223725B2 (en) 1987-05-25

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