JPS5564518A - Carcinostatic composition - Google Patents
Carcinostatic compositionInfo
- Publication number
- JPS5564518A JPS5564518A JP13768678A JP13768678A JPS5564518A JP S5564518 A JPS5564518 A JP S5564518A JP 13768678 A JP13768678 A JP 13768678A JP 13768678 A JP13768678 A JP 13768678A JP S5564518 A JPS5564518 A JP S5564518A
- Authority
- JP
- Japan
- Prior art keywords
- thymidine
- preparation containing
- fluorouracil
- mole
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: 5-Fluorouracil and thymidine are used as the effective ingredients to produce title composition with improved balance between the effectiveness and the side effects.
CONSTITUTION: At least one of 5-fluorouracils selected from the compounds of the formula (R1 and R2 are H, alkoxymethyl, tetrahydrofurfuryl, alkylcarbamoyl) and thymidine are added in a proportion of 1 mole of the former and over 0.5 mole of the latter and they are prepared to an oral preparation containing 20W1200mg/d of 5-fluorouracil, injection preparation containing 50W2000mg/d, and suppository preparation containing 250W2000mg/d. Although thymidine itself does not have carcinostatice activity, the combination remarkably increases the effect to give said carcinostatic composition with extremely increased LD50/ED50.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13768678A JPS5564518A (en) | 1978-11-07 | 1978-11-07 | Carcinostatic composition |
GB7908960A GB2016921B (en) | 1978-03-27 | 1979-03-14 | Anti cancer compositions containing uracil derivatives |
CH272679A CH639274A5 (en) | 1978-03-27 | 1979-03-23 | ANTI-DRINKING AGENTS. |
FR7907523A FR2420974A1 (en) | 1978-03-27 | 1979-03-26 | MEDICINE BASED ON URACIL DERIVATIVES |
DE2912112A DE2912112C2 (en) | 1978-03-27 | 1979-03-27 | Anti-cancer drug |
IT67629/79A IT1119283B (en) | 1978-03-27 | 1979-03-27 | ANTI-CANCER COMPOSITION |
US06/552,263 US4650801A (en) | 1978-03-27 | 1983-11-16 | Anti-cancer compositions for delivering 5-fluorouracil |
US06/932,516 US4914105A (en) | 1978-03-27 | 1986-11-20 | Anti-cancer compositions for delivering 5-fluorouracil |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13768678A JPS5564518A (en) | 1978-11-07 | 1978-11-07 | Carcinostatic composition |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5564518A true JPS5564518A (en) | 1980-05-15 |
JPS6223725B2 JPS6223725B2 (en) | 1987-05-25 |
Family
ID=15204428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13768678A Granted JPS5564518A (en) | 1978-03-27 | 1978-11-07 | Carcinostatic composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5564518A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0997473B1 (en) * | 1997-06-03 | 2003-04-09 | ITOCHU Techno-Chemical Inc. | Natural antitumor or antiviral substances and use of the same |
-
1978
- 1978-11-07 JP JP13768678A patent/JPS5564518A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6223725B2 (en) | 1987-05-25 |
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