JPS5589224A - Anti-tumor agent - Google Patents

Anti-tumor agent

Info

Publication number
JPS5589224A
JPS5589224A JP16196578A JP16196578A JPS5589224A JP S5589224 A JPS5589224 A JP S5589224A JP 16196578 A JP16196578 A JP 16196578A JP 16196578 A JP16196578 A JP 16196578A JP S5589224 A JPS5589224 A JP S5589224A
Authority
JP
Japan
Prior art keywords
fluorouracil
same time
formula
compound
thymine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16196578A
Other languages
Japanese (ja)
Inventor
Setsuo Fujii
Yoshinori Sakai
Yutaro Sasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP16196578A priority Critical patent/JPS5589224A/en
Publication of JPS5589224A publication Critical patent/JPS5589224A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To povide an anti-tumor agent having improved anti-tumor activity while keeping the toxicity and side effects unchanged, by compounding a 5-fluorouracil with thymine, etc. having little anti-tumor activity.
CONSTITUTION: A composition containing (A) a compound of formula I (R1,2 are H, halogen, alkyl, aryl, acyl, etc.; provided that R1 and not R2 are H at the same time) or a 5-fluorouracil derivative of formula II (R3,4 are H, alkyl, aryl, etc.; provided that R3 and R4 are not H at the same time), e.g. N1-(2'-tatrahydrofuryl)-5- fluorouracil, and (B) a compound of formula III (R5,6 are H, halogen, carboxy, etc.; provided that R5 and R6 are not H at the same time) or a compound of formula IV (R7,8,9 are H, etc.; provided that R7 and R8 are not H at the same time), e.g. thymine, orotic acid, etc. The composition has higher activity and lower toxicity than the combined use of FT-207 or uracil and 5-fluorouracil.
COPYRIGHT: (C)1980,JPO&Japio
JP16196578A 1978-12-28 1978-12-28 Anti-tumor agent Pending JPS5589224A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16196578A JPS5589224A (en) 1978-12-28 1978-12-28 Anti-tumor agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16196578A JPS5589224A (en) 1978-12-28 1978-12-28 Anti-tumor agent

Publications (1)

Publication Number Publication Date
JPS5589224A true JPS5589224A (en) 1980-07-05

Family

ID=15745430

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16196578A Pending JPS5589224A (en) 1978-12-28 1978-12-28 Anti-tumor agent

Country Status (1)

Country Link
JP (1) JPS5589224A (en)

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