ES8402285A1 - Dioxopiperazine derivatives - Google Patents

Dioxopiperazine derivatives

Info

Publication number
ES8402285A1
ES8402285A1 ES518304A ES518304A ES8402285A1 ES 8402285 A1 ES8402285 A1 ES 8402285A1 ES 518304 A ES518304 A ES 518304A ES 518304 A ES518304 A ES 518304A ES 8402285 A1 ES8402285 A1 ES 8402285A1
Authority
ES
Spain
Prior art keywords
benzyl
dioxopiperazine derivatives
dioxopiperazine
derivatives
pyrimidinylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518304A
Other languages
Spanish (es)
Other versions
ES518304A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of ES8402285A1 publication Critical patent/ES8402285A1/en
Publication of ES518304A0 publication Critical patent/ES518304A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1-Benzyl-4-[4-(2-pyrimidinylamino)benzyl]- 2,3-dioxopiperazine derivatives represented by the formula: < IMAGE > wherein R<1> is optionally substituted hydrocarbyl or acyl, R<2> is H or alkyl and X is O or S, and salts thereof have an excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.
ES518304A 1981-02-06 1982-12-16 A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1-BENCIL-4- (4- (2-PIRIMIDINILAMINO) BENCIL) -2,3-DIOXOPIPERAZINE OR ITS SALTS. Granted ES518304A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56015837A JPS57140783A (en) 1981-02-06 1981-02-06 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same

Publications (2)

Publication Number Publication Date
ES8402285A1 true ES8402285A1 (en) 1984-01-16
ES518304A0 ES518304A0 (en) 1984-01-16

Family

ID=11899943

Family Applications (2)

Application Number Title Priority Date Filing Date
ES509391A Expired ES8304970A1 (en) 1981-02-06 1982-02-05 Dioxopiperazine derivatives
ES518304A Granted ES518304A0 (en) 1981-02-06 1982-12-16 A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1-BENCIL-4- (4- (2-PIRIMIDINILAMINO) BENCIL) -2,3-DIOXOPIPERAZINE OR ITS SALTS.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES509391A Expired ES8304970A1 (en) 1981-02-06 1982-02-05 Dioxopiperazine derivatives

Country Status (12)

Country Link
JP (1) JPS57140783A (en)
KR (1) KR880001105B1 (en)
AU (1) AU537512B2 (en)
BE (1) BE892032A (en)
CH (1) CH651036A5 (en)
DE (1) DE3204074A1 (en)
ES (2) ES8304970A1 (en)
FR (1) FR2499569A1 (en)
GB (1) GB2094296B (en)
IT (1) IT1154274B (en)
NL (1) NL8200451A (en)
SE (1) SE449101B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1244542C (en) * 1996-12-24 2006-03-08 中外制药株式会社 Aromatic amine derivatives having NOS inhibitory effect
TWI803615B (en) * 2018-04-11 2023-06-01 日商三菱瓦斯化學股份有限公司 Method for producing dicyanoalkane and bis(aminomethyl)alkane

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5618969A (en) * 1979-07-24 1981-02-23 Toyama Chem Co Ltd Novel 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative, its acid addition salt, and their preparation

Also Published As

Publication number Publication date
AU8024082A (en) 1982-08-12
JPS6366319B2 (en) 1988-12-20
GB2094296A (en) 1982-09-15
FR2499569A1 (en) 1982-08-13
DE3204074C2 (en) 1987-12-23
AU537512B2 (en) 1984-06-28
ES509391A0 (en) 1983-03-16
IT1154274B (en) 1987-01-21
ES518304A0 (en) 1984-01-16
FR2499569B1 (en) 1985-02-22
CH651036A5 (en) 1985-08-30
BE892032A (en) 1982-08-05
ES8304970A1 (en) 1983-03-16
NL8200451A (en) 1982-09-01
KR880001105B1 (en) 1988-06-29
KR830009090A (en) 1983-12-17
SE449101B (en) 1987-04-06
JPS57140783A (en) 1982-08-31
IT8247729A0 (en) 1982-02-05
GB2094296B (en) 1985-02-13
SE8200679L (en) 1982-09-22
DE3204074A1 (en) 1982-10-28

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