JPS57140783A - 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same - Google Patents

1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same

Info

Publication number
JPS57140783A
JPS57140783A JP56015837A JP1583781A JPS57140783A JP S57140783 A JPS57140783 A JP S57140783A JP 56015837 A JP56015837 A JP 56015837A JP 1583781 A JP1583781 A JP 1583781A JP S57140783 A JPS57140783 A JP S57140783A
Authority
JP
Japan
Prior art keywords
benzyl
compound
salt
formula
dioxopiperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56015837A
Other languages
Japanese (ja)
Other versions
JPS6366319B2 (en
Inventor
Takako Hori
Chosaku Yoshida
Yasuo Kiba
Takatsune Takeno
Joji Nakano
Jun Nitta
Sumiko Kishimoto
Shohachi Murakami
Hisatsugu Tsuda
Isamu Saikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP56015837A priority Critical patent/JPS57140783A/en
Priority to US06/345,055 priority patent/US4459407A/en
Priority to CH674/82A priority patent/CH651036A5/en
Priority to FR8201925A priority patent/FR2499569A1/en
Priority to IT8247729A priority patent/IT1154274B/en
Priority to ES509391A priority patent/ES8304970A1/en
Priority to SE8200679A priority patent/SE449101B/en
Priority to GB8203333A priority patent/GB2094296B/en
Priority to AU80240/82A priority patent/AU537512B2/en
Priority to NL8200451A priority patent/NL8200451A/en
Priority to BE0/207239A priority patent/BE892032A/en
Priority to DE19823204074 priority patent/DE3204074A1/en
Priority to KR8200513A priority patent/KR880001105B1/en
Publication of JPS57140783A publication Critical patent/JPS57140783A/en
Priority to ES518304A priority patent/ES8402285A1/en
Publication of JPS6366319B2 publication Critical patent/JPS6366319B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

NEW MATERIAL:The compound of formulaI[R1 is (substituted) alkyl, cycloalkyl, aralkyl, alkenyl, alkadienyl, aryl or acryl; R2 is H or alkyl; X is O or S]and its salt.
EXAMPLE: 1-Benzyl-40{4-[ N-methoxymethyl-N-( 2-pyrimidinyl )amino]benzyl}- 2,3-dioxopiperazine.
USE: A carcinostatic agent which can be administered orally or by injection, especially preferably by oral administration.
PROCESS: The compound of formulaIis prepared by reacting 1-benzyl-40[4-(2- pyrimidinyl-amino)benzyl]-2,3-dioxopiperazine or its reactive derivative with the compound of formula II. As an alternative method, the compound of formula IV can be prepared by reacting the compound of formula III (R3 is group defined in R1 excluding acyl) with the compound of formula H-X-R4 (R4 is group defined in R3).
COPYRIGHT: (C)1982,JPO&Japio
JP56015837A 1979-07-24 1981-02-06 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same Granted JPS57140783A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP56015837A JPS57140783A (en) 1981-02-06 1981-02-06 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same
US06/345,055 US4459407A (en) 1979-07-24 1982-02-02 1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives and salts thereof
CH674/82A CH651036A5 (en) 1981-02-06 1982-02-04 1-BENZYL-4- (4- (2-PYRIMIDINYLAMINO) -BENZYL) -2,3-DIOXOPIPERAZINE DERIVATIVES, SALTS THEREOF, METHOD FOR PRODUCING THE SAME AND CARCINOSTATIC AGENTS WITH THE SAME.
GB8203333A GB2094296B (en) 1981-02-06 1982-02-05 Dioxopiperazine derivatives
BE0/207239A BE892032A (en) 1981-02-06 1982-02-05 NOVEL 1-BENZYL-4- (4- (2-PYRIMIDINYLAMINO) BENZYL-2,3-DIOXOPIPERAZINES DERIVATIVES, THEIR SALTS, A PROCESS FOR THE PREPARATION OF SUCH DERIVATIVES AND SALTS AND A CARCINOSTATIC AGENT CONTAINING THEM
ES509391A ES8304970A1 (en) 1981-02-06 1982-02-05 Dioxopiperazine derivatives
SE8200679A SE449101B (en) 1981-02-06 1982-02-05 1-BENZYL-4- / 4- (2-PYRIMIDINYLAMINO) BENZYL / -2,3-DIOXOPIPERAZINE DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND CARCINOSTATIC AGENTS
FR8201925A FR2499569A1 (en) 1981-02-06 1982-02-05 NOVEL DERIVATIVES OF 1-BENZYL-4- (4- (2-PYRIMIDINYLAMINO) BENZYL) -2,3-DIOXOPIPERAZINES, THEIR SALTS, A PROCESS FOR PREPARING THESE DERIVATIVES AND SALTS AND A CARCINOSTATIC AGENT CONTAINING SAME
AU80240/82A AU537512B2 (en) 1981-02-06 1982-02-05 Dioxopiperazine derivatives
NL8200451A NL8200451A (en) 1981-02-06 1982-02-05 1-BENZYL-4-4- (2-PYRIMIDINYLAMINO) BENZYL-2,3-DIOXOPIPERAZINE DERIVATIVES, SALTS AND METHODS FOR PREPARING THESE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
IT8247729A IT1154274B (en) 1981-02-06 1982-02-05 PIPERAZINE DERIVATIVES, PROCEDURE TO PRODUCE THEM AND CARCINOSTATIC AGENTS THAT CONTAIN THEM
DE19823204074 DE3204074A1 (en) 1981-02-06 1982-02-06 NEW 1-BENZYL-4- (4- (2-PYRIMIDINYLAMINO) -BENZYL) -2,3-DIOXOPIPERAZINE DERIVATIVES, SALTS THEREOF, METHOD FOR PRODUCING THE SAME AND CARCINOSTATIC AGENTS WITH THE SAME
KR8200513A KR880001105B1 (en) 1981-02-06 1982-02-06 Process for preparing 1-benzil-4-(4-(2-pyrimidinylamino)benjil)-2,3-dioxopiperajine derivatives
ES518304A ES8402285A1 (en) 1981-02-06 1982-12-16 Dioxopiperazine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56015837A JPS57140783A (en) 1981-02-06 1981-02-06 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same

Publications (2)

Publication Number Publication Date
JPS57140783A true JPS57140783A (en) 1982-08-31
JPS6366319B2 JPS6366319B2 (en) 1988-12-20

Family

ID=11899943

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56015837A Granted JPS57140783A (en) 1979-07-24 1981-02-06 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same

Country Status (12)

Country Link
JP (1) JPS57140783A (en)
KR (1) KR880001105B1 (en)
AU (1) AU537512B2 (en)
BE (1) BE892032A (en)
CH (1) CH651036A5 (en)
DE (1) DE3204074A1 (en)
ES (2) ES8304970A1 (en)
FR (1) FR2499569A1 (en)
GB (1) GB2094296B (en)
IT (1) IT1154274B (en)
NL (1) NL8200451A (en)
SE (1) SE449101B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028257A1 (en) * 1996-12-24 1998-07-02 Chugai Seiyaku Kabushiki Kaisha Aromatic amine derivatives having nos inhibitory effect

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111936461B (en) * 2018-04-11 2023-09-05 三菱瓦斯化学株式会社 Process for producing dicyanoalkane and bis (aminomethyl) alkane

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5618969A (en) * 1979-07-24 1981-02-23 Toyama Chem Co Ltd Novel 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative, its acid addition salt, and their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028257A1 (en) * 1996-12-24 1998-07-02 Chugai Seiyaku Kabushiki Kaisha Aromatic amine derivatives having nos inhibitory effect

Also Published As

Publication number Publication date
GB2094296A (en) 1982-09-15
KR880001105B1 (en) 1988-06-29
BE892032A (en) 1982-08-05
NL8200451A (en) 1982-09-01
DE3204074A1 (en) 1982-10-28
AU537512B2 (en) 1984-06-28
SE8200679L (en) 1982-09-22
JPS6366319B2 (en) 1988-12-20
FR2499569B1 (en) 1985-02-22
SE449101B (en) 1987-04-06
DE3204074C2 (en) 1987-12-23
IT8247729A0 (en) 1982-02-05
IT1154274B (en) 1987-01-21
CH651036A5 (en) 1985-08-30
FR2499569A1 (en) 1982-08-13
ES509391A0 (en) 1983-03-16
ES518304A0 (en) 1984-01-16
ES8402285A1 (en) 1984-01-16
GB2094296B (en) 1985-02-13
ES8304970A1 (en) 1983-03-16
AU8024082A (en) 1982-08-12
KR830009090A (en) 1983-12-17

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