JPS57144217A - Antitumor agent - Google Patents

Antitumor agent

Info

Publication number
JPS57144217A
JPS57144217A JP3081381A JP3081381A JPS57144217A JP S57144217 A JPS57144217 A JP S57144217A JP 3081381 A JP3081381 A JP 3081381A JP 3081381 A JP3081381 A JP 3081381A JP S57144217 A JPS57144217 A JP S57144217A
Authority
JP
Japan
Prior art keywords
cytosine
fluorocytosine
antitumor agent
antitumor
methylcytosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3081381A
Other languages
Japanese (ja)
Inventor
Yoshio Kawamura
Naoshi Nishiyama
Yutaka Morita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JNC Corp
Original Assignee
Chisso Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chisso Corp filed Critical Chisso Corp
Priority to JP3081381A priority Critical patent/JPS57144217A/en
Publication of JPS57144217A publication Critical patent/JPS57144217A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: An antitumor agent having extremely raised antitumor action, obtained by combining an antitumor agent consisting of 5-fluorocytosine and cytosine deaminase with cytosine and/or 5-methylcytosine.
CONSTITUTION: An antitumor agent consisting of 5-fluorocytosine and cytosine deaminase is blended with 0.5W20pts.wt., preferably 4W6pts.wt. based on 1pts.wt. 5-fluorocytosine of cytosine and/or 5-methyl cytosine. These compounds have no antitumor action at all individually, but combined and used, they exhibit extremely high antitumor action. 5-Fluorocytosine, cytosine and/or 5-methylcytosine are separately or simultaneously medicated to the whole body, and cytosine deaminase is locally medicated to the tumor tissue. By actions of various kinds of enzymes 5-fluorocytosine is converted into 5-fluorouracil.
COPYRIGHT: (C)1982,JPO&Japio
JP3081381A 1981-03-04 1981-03-04 Antitumor agent Pending JPS57144217A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3081381A JPS57144217A (en) 1981-03-04 1981-03-04 Antitumor agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3081381A JPS57144217A (en) 1981-03-04 1981-03-04 Antitumor agent

Publications (1)

Publication Number Publication Date
JPS57144217A true JPS57144217A (en) 1982-09-06

Family

ID=12314124

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3081381A Pending JPS57144217A (en) 1981-03-04 1981-03-04 Antitumor agent

Country Status (1)

Country Link
JP (1) JPS57144217A (en)

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